\n", "Transcription factor gene list: a list of transcription factors of interest. This list is requried for the network inference step. Data can be downloaded through pySCENIC_TF_list and TF_lists.\n", "\n", "Ranked whole genome databases: Databases ranking the whole genome of species of interest based on transcription factors in feather v2 format. Data can typically be downloaded from public databases, through cisTarget databases.\n", "\n", "Motif to TF annotation databases: Motif databases (in tbl format) serve as a reference for identifying potential TF binding sites in the genome and inferring the regulatory relationships between TFs and target genes. Data can be downloaded through Motif2TF annotations." ] }, { "cell_type": "code", "execution_count": 13, "id": "313fb32b", "metadata": {}, "outputs": [], "source": [ "tfs_fn = 'mouse_tfs.txt'\n", "database_fn = 'mm10_10kbp_up_10kbp_down_full_tx_v10_clust.genes_vs_motifs.rankings.feather'\n", "motif_anno_fn = 'motifs-v10nr_clust-nr.mgi-m0.001-o0.0.tbl'" ] }, { "cell_type": "markdown", "id": "3af8f5d7", "metadata": {}, "source": [ "### 2. Create a spagrn object\n", "pos_label is the obsm key where spots coordinates were stored." ] }, { "cell_type": "code", "execution_count": null, "id": "0ff9b0dd", "metadata": {}, "outputs": [], "source": [ "grn = irn(data, project_name='mouse_brain')" ] }, { "cell_type": "markdown", "id": "8d3205a6", "metadata": {}, "source": [ "[optional] set parameters of the model:\n", "1. rank_threshold: number of ranked genes;\n", "2. prune_auc_threshold: fraction of the ranked genome when computing AUC in prune modules step;\n", "3. nes_threshold: normalized enrichment score (nes) threshold to select enriched motifs;\n", "4. auc_threshold: fraction of the ranked genome when computing AUC;" ] }, { "cell_type": "code", "execution_count": 15, "id": "13f83012", "metadata": {}, "outputs": [], "source": [ "grn.add_params({'prune_auc_threshold': 0.05, 'rank_threshold': 9000, 'auc_threshold': 0.05})" ] }, { "cell_type": "markdown", "id": "abcde939", "metadata": {}, "source": [ "### 3. Set Ligand-Receptor data\n", "Pre-computed ligand-recpetor datasets obtained from CellPhoneDB." ] }, { "cell_type": "code", "execution_count": null, "id": "1d23696d", "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ " from to database source\n", "0 2300002M23Rik Ddr1 omnipath omnipath\n", "1 2610528A11Rik Gpr15 omnipath omnipath\n", "2 9530003J23Rik Itgal omnipath omnipath\n", "3 a Atrn omnipath omnipath\n", "4 a F11r omnipath omnipath\n", "... ... ... ... ...\n", "4981 ZNRF3 FZD4 omnipath omnipath\n", "4982 ZP3 EGFR omnipath omnipath\n", "4983 ZP3 CHRNA7 omnipath omnipath\n", "4984 ZP3 MERTK omnipath omnipath\n", "4985 ZPBP2 CD80 omnipath omnipath\n", "\n", "[10654 rows x 4 columns]\n" ] } ], "source": [ "niche_human = pd.read_csv('resource/lr_network_human.csv')\n", "niche_mouse = pd.read_csv('resource/lr_network_mouse.csv')\n", "# concat the databases together if you are using multiple ligand-receptors databases\n", "niches = pd.concat([niche_mouse, niche_human])\n", "print(niches)" ] }, { "cell_type": "markdown", "id": "c452c883", "metadata": {}, "source": [ "### 4. Construct the network\n", "In order to construct a GRN:\n", "- database_fn\n", "- motif_anno_fn\n", "- niche_df\n", "- gene_list: A list of interested genes to calculate co-expression values with TF genes. e.g. a list of HVGs.\n", "\n", "- num_workers: number of thread.\n", "- cache: if use saved intermediate result files.\n", "- output_dir: output directory.\n", "- save_tmp: if save intermediate results onto disk.\n", "\n", "- layer_key: Key in adata.layers with count data, uses adata.X if None.\n", "- latent_obsm_key: Key in adata.obsm where cell/spot coordinates are.\n", "- cluster_label: Key in adata.obs with cluster/cell type labels.\n", "\n", "- model: Specifies the null model to use for gene expression.\n", "- n_neighbors: n cell/spots to consider as \"neighbors\" when computing spatial autocorrelation and gene co-expression.\n", "- methods: a list of spatial autocorrelation statistics, options are 'FDR_C', 'FDR_I', 'FDR_G', 'FDR'.\n", "- operation: options are 'intersection' and 'union'.\n", "- mode: bi-variate Geary's C or bi-variate Moran's R when computing gene co-expression. options are 'moran' and 'geary'." ] }, { "cell_type": "code", "execution_count": null, "id": "32df5bdc", "metadata": {}, "outputs": [ { "name": "stderr", "output_type": "stream", "text": [ "/Users/Oreo/anaconda3/envs/spagrn/lib/python3.8/site-packages/hotspot/hotspot.py:98: UserWarning: Hotspot will work faster when counts are a csc sparse matrix.\n", " warnings.warn(\n", "100%|█████████████████████████████████████████████████████████████████████████████████| 9788/9788 [03:48<00:00, 42.82it/s]\n" ] }, { "name": "stdout", "output_type": "stream", "text": [ "Computing spatial weights matrix...\n" ] }, { "ename": "ModuleNotFoundError", "evalue": "No module named 'pysal'", "output_type": "error", "traceback": [ "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", "\u001b[0;31mModuleNotFoundError\u001b[0m Traceback (most recent call last)", "Cell \u001b[0;32mIn[18], line 1\u001b[0m\n\u001b[0;32m----> 1\u001b[0m \u001b[43mgrn\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43minfer\u001b[49m\u001b[43m(\u001b[49m\u001b[43mdatabase_fn\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 2\u001b[0m \u001b[43m \u001b[49m\u001b[43mmotif_anno_fn\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 3\u001b[0m \u001b[43m \u001b[49m\u001b[43mtfs_fn\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 4\u001b[0m \u001b[43m \u001b[49m\u001b[43mniche_df\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mniches\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 5\u001b[0m \u001b[43m \u001b[49m\u001b[43mnum_workers\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[38;5;241;43m12\u001b[39;49m\u001b[43m,\u001b[49m\n\u001b[1;32m 6\u001b[0m \u001b[43m \u001b[49m\u001b[43mlayers\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[38;5;124;43mcounts\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[43m,\u001b[49m\n\u001b[1;32m 7\u001b[0m \u001b[43m \u001b[49m\u001b[43mlatent_obsm_key\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[38;5;124;43mspatial\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[43m,\u001b[49m\n\u001b[1;32m 8\u001b[0m \u001b[43m \u001b[49m\u001b[43mn_neighbors\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[38;5;241;43m10\u001b[39;49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\n\u001b[1;32m 9\u001b[0m \u001b[43m \u001b[49m\u001b[43mmode\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[38;5;124;43mmoran\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[43m,\u001b[49m\n\u001b[1;32m 10\u001b[0m \u001b[43m \u001b[49m\u001b[43mcluster_label\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[38;5;124;43mannotation\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[43m,\u001b[49m\n\u001b[1;32m 11\u001b[0m \u001b[43m \u001b[49m\u001b[43mproject_name\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[38;5;124;43mmouse_brain\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[43m)\u001b[49m\n", "File \u001b[0;32m~/Library/CloudStorage/OneDrive-BGIHongKongTechCo.,Limited/PycharmProjects/SpaGRN/spagrn/regulatory_network.py:170\u001b[0m, in \u001b[0;36mInferNetwork.infer\u001b[0;34m(self, databases, motif_anno_fn, tfs_fn, gene_list, cluster_label, niche_df, receptor_key, num_workers, save_tmp, cache, project_name, layers, model, latent_obsm_key, umi_counts_obs_key, n_neighbors, weighted_graph, rho_mask_dropouts, local, methods, operation, combine, mode, somde_k, noweights, normalize)\u001b[0m\n\u001b[1;32m 167\u001b[0m dbs \u001b[38;5;241m=\u001b[39m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mload_database(databases)\n\u001b[1;32m 169\u001b[0m \u001b[38;5;66;03m# 3. GRN Inference\u001b[39;00m\n\u001b[0;32m--> 170\u001b[0m adjacencies \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mspg\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mdata\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 171\u001b[0m \u001b[43m \u001b[49m\u001b[43mgene_list\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mgene_list\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 172\u001b[0m \u001b[43m \u001b[49m\u001b[43mtf_list\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mtfs\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 173\u001b[0m \u001b[43m \u001b[49m\u001b[43mjobs\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mnum_workers\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 174\u001b[0m \u001b[43m \u001b[49m\u001b[43mlayer_key\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mlayers\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 175\u001b[0m \u001b[43m \u001b[49m\u001b[43mmodel\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mmodel\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 176\u001b[0m \u001b[43m \u001b[49m\u001b[43mlatent_obsm_key\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mlatent_obsm_key\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 177\u001b[0m \u001b[43m \u001b[49m\u001b[43mumi_counts_obs_key\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mumi_counts_obs_key\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 178\u001b[0m \u001b[43m \u001b[49m\u001b[43mn_neighbors\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mn_neighbors\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 179\u001b[0m \u001b[43m \u001b[49m\u001b[43mweighted_graph\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mweighted_graph\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 180\u001b[0m \u001b[43m \u001b[49m\u001b[43mcache\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mcache\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 181\u001b[0m \u001b[43m \u001b[49m\u001b[43msave_tmp\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43msave_tmp\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 182\u001b[0m \u001b[43m \u001b[49m\u001b[43mfn\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[38;5;124;43mf\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[38;5;132;43;01m{\u001b[39;49;00m\u001b[43mproject_name\u001b[49m\u001b[38;5;132;43;01m}\u001b[39;49;00m\u001b[38;5;124;43m_\u001b[39;49m\u001b[38;5;132;43;01m{\u001b[39;49;00m\u001b[43mmode\u001b[49m\u001b[38;5;132;43;01m}\u001b[39;49;00m\u001b[38;5;124;43m_adj.csv\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[43m,\u001b[49m\n\u001b[1;32m 183\u001b[0m \u001b[43m \u001b[49m\u001b[43mlocal\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mlocal\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 184\u001b[0m \u001b[43m \u001b[49m\u001b[43mmethods\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mmethods\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 185\u001b[0m \u001b[43m \u001b[49m\u001b[43moperation\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43moperation\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 186\u001b[0m \u001b[43m \u001b[49m\u001b[43mcombine\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mcombine\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 187\u001b[0m \u001b[43m \u001b[49m\u001b[43mmode\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mmode\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 188\u001b[0m \u001b[43m \u001b[49m\u001b[43msomde_k\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43msomde_k\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 190\u001b[0m \u001b[38;5;66;03m# 4. Compute Modules\u001b[39;00m\n\u001b[1;32m 191\u001b[0m \u001b[38;5;66;03m# ctxcore.genesig.Regulon\u001b[39;00m\n\u001b[1;32m 192\u001b[0m modules \u001b[38;5;241m=\u001b[39m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mget_modules(adjacencies, df, rho_mask_dropouts\u001b[38;5;241m=\u001b[39mrho_mask_dropouts, prefix\u001b[38;5;241m=\u001b[39mproject_name)\n", "File \u001b[0;32m~/Library/CloudStorage/OneDrive-BGIHongKongTechCo.,Limited/PycharmProjects/SpaGRN/spagrn/regulatory_network.py:581\u001b[0m, in \u001b[0;36mInferNetwork.spg\u001b[0;34m(self, data, gene_list, layer_key, model, latent_obsm_key, umi_counts_obs_key, weighted_graph, n_neighbors, fdr_threshold, tf_list, save_tmp, jobs, cache, local, methods, operation, combine, somde_k, fn, mode, **kwargs)\u001b[0m\n\u001b[1;32m 578\u001b[0m hs_results \u001b[38;5;241m=\u001b[39m hs\u001b[38;5;241m.\u001b[39mcompute_autocorrelations()\n\u001b[1;32m 580\u001b[0m \u001b[38;5;66;03m# 1: Select genes\u001b[39;00m\n\u001b[0;32m--> 581\u001b[0m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mspatial_autocorrelation\u001b[49m\u001b[43m(\u001b[49m\u001b[43mdata\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 582\u001b[0m \u001b[43m \u001b[49m\u001b[43mlayer_key\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mlayer_key\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 583\u001b[0m \u001b[43m \u001b[49m\u001b[43mlatent_obsm_key\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mlatent_obsm_key\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 584\u001b[0m \u001b[43m \u001b[49m\u001b[43mn_neighbors\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mn_neighbors\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 585\u001b[0m \u001b[43m \u001b[49m\u001b[43msomde_k\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43msomde_k\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 586\u001b[0m \u001b[43m 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local\u001b[38;5;241m=\u001b[39mlocal,\n\u001b[1;32m 594\u001b[0m combine\u001b[38;5;241m=\u001b[39mcombine,\n\u001b[1;32m 595\u001b[0m operation\u001b[38;5;241m=\u001b[39moperation)\n", "File \u001b[0;32m~/Library/CloudStorage/OneDrive-BGIHongKongTechCo.,Limited/PycharmProjects/SpaGRN/spagrn/regulatory_network.py:371\u001b[0m, in \u001b[0;36mInferNetwork.spatial_autocorrelation\u001b[0;34m(self, adata, layer_key, latent_obsm_key, n_neighbors, somde_k, n_processes, local, cache)\u001b[0m\n\u001b[1;32m 368\u001b[0m \u001b[38;5;28mprint\u001b[39m(\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mComputing spatial weights matrix...\u001b[39m\u001b[38;5;124m'\u001b[39m)\n\u001b[1;32m 369\u001b[0m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mind, neighbors, \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mweights_n \u001b[38;5;241m=\u001b[39m neighbors_and_weights(adata, latent_obsm_key\u001b[38;5;241m=\u001b[39mlatent_obsm_key,\n\u001b[1;32m 370\u001b[0m n_neighbors\u001b[38;5;241m=\u001b[39mn_neighbors)\n\u001b[0;32m--> 371\u001b[0m Weights \u001b[38;5;241m=\u001b[39m \u001b[43mget_w\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mind\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mweights_n\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 372\u001b[0m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mweights \u001b[38;5;241m=\u001b[39m Weights\n\u001b[1;32m 374\u001b[0m more_stats \u001b[38;5;241m=\u001b[39m pd\u001b[38;5;241m.\u001b[39mDataFrame(index\u001b[38;5;241m=\u001b[39madata\u001b[38;5;241m.\u001b[39mvar_names)\n", "File \u001b[0;32m~/Library/CloudStorage/OneDrive-BGIHongKongTechCo.,Limited/PycharmProjects/SpaGRN/spagrn/autocor.py:129\u001b[0m, in \u001b[0;36mget_w\u001b[0;34m(ind, weights_n)\u001b[0m\n\u001b[1;32m 127\u001b[0m nei \u001b[38;5;241m=\u001b[39m nind\u001b[38;5;241m.\u001b[39mtranspose()\u001b[38;5;241m.\u001b[39mto_dict(\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mlist\u001b[39m\u001b[38;5;124m'\u001b[39m)\n\u001b[1;32m 128\u001b[0m w_dict \u001b[38;5;241m=\u001b[39m weights_n\u001b[38;5;241m.\u001b[39mreset_index(drop\u001b[38;5;241m=\u001b[39m\u001b[38;5;28;01mTrue\u001b[39;00m)\u001b[38;5;241m.\u001b[39mtranspose()\u001b[38;5;241m.\u001b[39mto_dict(\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mlist\u001b[39m\u001b[38;5;124m'\u001b[39m)\n\u001b[0;32m--> 129\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mpysal\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mlib\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m weights\n\u001b[1;32m 130\u001b[0m w \u001b[38;5;241m=\u001b[39m weights\u001b[38;5;241m.\u001b[39mW(nei, weights\u001b[38;5;241m=\u001b[39mw_dict)\n\u001b[1;32m 131\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m w\n", "\u001b[0;31mModuleNotFoundError\u001b[0m: No module named 'pysal'" ] } ], "source": [ "grn.infer(database_fn,\n", " motif_anno_fn,\n", " tfs_fn,\n", " niche_df=niches,\n", " gene_list=None,\n", " num_workers=20,\n", " cache=True,\n", " output_dir='exp/ouput',\n", " save_tmp=True,\n", " layers='raw_counts',\n", " latent_obsm_key='spatial',\n", " model='bernoulli',\n", " n_neighbors=10,\n", " methods=['FDR_I','FDR_C','FDR_G'],\n", " operation='intersection',\n", " mode='geary',\n", " cluster_label='annotation')" ] }, { "cell_type": "markdown", "id": "db9108c4-fb19-4f90-b00c-bf7557efa9a2", "metadata": {}, "source": [ "## Part II. Interpreting the results\n", "The results of Gene Regulatory Network were stored in an AnnData object." ] }, { "cell_type": "code", "execution_count": null, "id": "f2afbf39-b86b-436d-8fe0-1210beb3f135", "metadata": {}, "outputs": [ { "data": { "text/plain": [ "AnnData object with n_obs × n_vars = 50140 × 23472\n", " obs: 'annotation', 'n_genes', 'n_counts'\n", " var: 'Gene', 'n_cells', 'n_counts'\n", " uns: 'adj', 'annotation_colors', 'method', 'pca', 'receptor_dict_all', 'receptors', 'receptors_all', 'regulon_dict', 'rss'\n", " obsm: 'X_pca', 'auc_mtx', 'isr', 'rep_auc_mtx', 'spatial'\n", " varm: 'PCs'\n", " layers: 'counts'" ] }, "execution_count": 19, "metadata": {}, "output_type": "execute_result" } ], "source": [ "adata = sc.read_h5ad('spg_spagrn_gearyc.h5ad')\n", "adata" ] }, { "cell_type": "markdown", "id": "376704db", "metadata": {}, "source": [ "Regulons were stored in adata.uns under key `regulon_dict` in dictionary format." ] }, { "cell_type": "code", "execution_count": null, "id": "ef57c05e-f510-4f49-994b-0a0de6bc4f11", "metadata": {}, "outputs": [ { "data": { "text/plain": [ "{'Atf2(+)': array(['Atp2b1', 'Atf2', 'Galnt13', 'Ube3a', 'Lrrc7', 'Adgrl3', 'Syt1',\n", " 'Sgcz', 'Akt3', 'Pafah1b1', 'Foxp1', 'Basp1', 'Hivep2', 'Elavl2',\n", " 'Stmn2', 'Rims2', 'Gphn', 'Stxbp5l', 'Kansl1', 'Cnksr2', 'Pja2',\n", " 'Tanc2', 'Mef2a', 'Grid2', 'Meg3', 'Fam19a2', 'Lingo2', 'Atxn1',\n", " 'Cdkl5', 'Sept7', 'Zfp385b', 'Zfp804a', 'Ntng1', 'Sntg1', 'R3hdm1',\n", " 'Ppp3cb', 'Epha6', 'Cdh8', 'Nlgn1', 'Rora', 'Zfr', 'Ttc3', 'Fgf12',\n", " 'Oxr1', 'Lrrc4c', 'Prr16', 'Dlgap1', 'Ptpn4', 'Arhgap21', 'Nbea',\n", " 'Camk2d', 'Lrfn5', 'Myh10', 'Gabrb2', 'Ralyl', 'Magi1', 'Kcnt2',\n", " 'Apba2', 'Frmpd4', 'Grm5', 'Cntn1', 'Ccser1', 'Kif1a', 'Nrn1',\n", " 'Kcnc2', 'Tenm4', 'Inpp4b', 'Bcl11a', 'Kcnj3', 'Vsnl1', 'Adgrb3',\n", " 'Pak3', 'Cadm3', 'Osbpl6', 'Ncor1', 'Dok6', 'Wdfy3', 'Efna5',\n", " 'Gria4', 'Peak1', 'Chsy3', 'Pam', 'Syndig1', 'Hecw1', 'Dpp10',\n", " 'Ppp3ca', 'Tmeff2', 'Arpp21', 'Gria2', 'Herc1', 'Snap25',\n", " 'Cacna2d1', 'Kif1b', 'Anks1b', 'Lmo4', 'Unc5d', 'Matr3', 'Csde1',\n", " 'Brinp1', 'Caln1', 'Nap1l1', 'Car10', 'Ppp1r9a', 'Cntnap2',\n", " 'Rgs17', 'Erc2', 'Arap2', 'Cltc', 'Rab6a', 'Nckap1', 'Gabra1',\n", " 'Cadps', 'Cadm2', 'Ywhaz', 'App', 'Calm2', '5730522E02Rik',\n", " 'Scn8a', 'Ppp2r2b', 'Mdga2', 'Ppm1l', 'Rims1', 'Gnas', 'Ppfia2',\n", " 'Ywhae', 'Aplp2', 'Ctnna2', 'Chd4', 'Trank1', 'Mapt', 'Rock2',\n", " 'Pcdh9', 'Sptan1', 'Dnm3', 'Mef2c', 'Fgf14', 'Camk1d', 'Sestd1',\n", " 'Psip1', 'Nkain2', 'Tcaf1', 'Atp6v1a', 'Zfp804b', 'Nucks1',\n", " 'Akap11', 'Grm1', 'Nptn', 'Ptprd', 'Ehbp1', 'Nrxn1', 'Map1a',\n", " 'Dlgap2', 'Map7d2', 'Abi2', 'Cdh6', 'Ndrg3', 'Eif4g2', 'Dock3',\n", " 'Elavl4', 'Unc80', 'Magi2', 'Epha5', 'Lrba', 'Gls', 'Xkr4',\n", " 'Ctnnd2', 'Unc79', 'Rad23b', 'Ssh2', 'Pak7', 'Pcsk2', 'Map1b',\n", " 'Ahi1', 'Plcb1', 'Sub1', 'Robo2', 'Csmd1', 'Hcn1', 'Grin2b',\n", " 'Grm7', 'Atrnl1', 'Thsd7b', 'Myrip', 'Dclk1', 'Jarid2', 'AI593442',\n", " 'Pcdh7', 'Camta1', 'Celf1', 'Rap1gds1', 'Kcnq3', 'Rtf1', 'Prkar1b',\n", " 'Hsp90ab1', 'Nefm', 'Ttll7', 'Syt7', 'Fam19a1', 'Frmd5', 'Kcnh7',\n", " 'Homer1', 'Hspa4l', 'Pkm', 'Cacnb2', 'Negr1', 'Gsk3b', 'Cacna1e',\n", " 'Tmem56', 'Dync1i1', 'Samd5', 'Nrg3', 'Ywhag', 'Serbp1', 'Map9',\n", " 'Robo1', 'Ppp3r1', 'Arf1', 'Osbpl1a', 'Fam155a', 'Tcf4', 'Mmp16',\n", " 'Dnajc6', 'Gabrg3', 'Ncam2', 'Herc3', 'Adcy8', 'Srrm2', 'Kcnq5',\n", " 'Gnao1', 'Tnik', 'Frmd4a', 'Cacna2d3', 'Pdp1', 'Pde10a', 'Stmn1',\n", " 'Fam135b', 'Eloc', 'Cyfip2', 'Rbfox1', 'Nrg1', 'Rbms3', 'Kcnd2',\n", " 'Bex2', 'Rtn3', 'Tmtc2', 'Dmxl2', 'Cntn4', 'Fam126b', 'Prkar1a',\n", " 'Snap91', 'March1', 'Pten', 'Kif21a', 'Ank2', 'Arhgef9', 'Ppp2ca',\n", " 'Kcnma1', 'Macrod2', 'Map2', 'Gabrg2', 'Lrp1b', 'Gap43', 'Man1a2',\n", " 'Ccdc136', 'Pgm2l1', 'Pacsin1', 'Lars2', 'Sv2a', 'Nrxn3', 'Grin2a',\n", " 'Cux2', 'Clstn1', 'Napb', 'Morf4l1', 'Astn2', 'Otud7a', 'Nmnat2',\n", " 'Cit', 'Atp2b2', 'Pfn2', 'Phf24', 'Adam22', 'Atl1', 'Cntn5',\n", " 'Phactr1', 'Hs6st3', 'Thy1', 'Rtn4', 'Clasp2', 'Dlgap4', 'Dcc',\n", " 'Slc24a2', 'Fgfr2', 'Pclo', 'Kcna2', 'Lsamp', 'Syne1', 'Park2',\n", " 'Prkcd', 'Cdk14', 'Snrpn', 'Grik2', 'Hdac9', 'Efr3a', 'Elavl3',\n", " 'Ywhab', 'Asap1', 'Rtn1', 'Tmod2', 'Zc3h7a', 'Celf2', 'Cd44',\n", " 'Eef1a2', 'Pak1', 'Pnisr', 'Cacnb4', 'Dnaja1', 'Nrip3', 'Cdc42bpa',\n", " 'Set', 'Rasgef1b', 'Dst', 'Slc25a4', 'Dmd', 'Cacna1a', 'Syn2',\n", " 'Pde1a', 'Rgs7bp', 'Plcxd2', 'Ghitm', 'Gabrb3', 'Rfx7', 'Atp6v1b2',\n", " 'Evi5', 'Oxct1', 'Rasgrp1', 'Dgki'], dtype=object),\n", " 'Atf4(+)': array(['Slc25a3', 'Sult4a1', 'Tspyl1', 'Ndufb2', 'Chgb', 'Cycs', 'Cds1',\n", " 'Scn1b', 'Ptprs', 'Map1lc3a', 'Slc6a17', 'Gabra1', 'Ap2s1',\n", " 'Rab6a', 'Atp6v0b', 'Hint1', 'Nsg1', 'Stxbp1', 'Gnas', 'Stmn1',\n", " 'Tspan7', 'Gabarapl1', 'Mat2b', 'Tmem59l', 'Faim2', 'Scamp5',\n", " 'Sst', 'Ociad1', 'Gde1', 'Dnm1', 'Gnb1', 'Vgf', 'Ttc9b', 'Cox4i1',\n", " 'Nat8l', 'Dctn3', 'Kif1a', 'Ndrg4', 'Cox5a', 'Rab3c', 'Cpe',\n", " 'Hsp90b1', 'Med26', 'Slc3a1', 'Cspg5', 'Nap1l5', 'Maged1',\n", " 'Spock2', 'Tbc1d9', 'Tbca', 'Slc25a4', 'Pitpna', 'Clstn3', 'Kif5a',\n", " 'Sod1', 'Bsg', 'Cox5b', 'Atp5j', 'Scg5', 'Atp1a3', 'Myl12b',\n", " 'Prkacb', 'Pcp4', 'Vamp2', 'Slc32a1', 'Usmg5', 'Syp', 'Rap1gds1',\n", " 'Osbpl1a', 'Mgst3', 'Nceh1', 'Arpc4', 'Lgi2', 'Cadm3', 'Mdh1',\n", " 'Atf4', 'Sept8', 'Atp5f1', 'Atp6ap2', 'Atp6v0e2', 'Stmn2', 'Ywhag',\n", " 'Atp1b1', 'Ndufc2', 'Ldhb', 'Hras', 'Stmn3', 'Caly'], dtype=object),\n", " 'Bcl11a(+)': array(['Kmt2e', 'Mpped2', 'Tanc2', 'Meg3', 'Atf2', 'Satb1', 'Cdk17',\n", " 'Slitrk5', 'Atp2b1', 'Stmn2', 'Cnksr2', 'Zfr', 'Syt1', 'Stxbp5l',\n", " 'Akt3', 'Sgcz', 'Ube3a', 'Rims2', 'Kcnt2', 'Ppp1r12a', 'Ttc3',\n", " 'Gnas', 'Fbxw7', 'Lrrc7', 'Wasf1', 'Foxp1', 'Sept7', 'Atxn1',\n", " 'Tceal3', 'Cdkl5', 'Pafah1b1', 'Grm8', 'Mef2a', 'Pja2', 'Nrn1',\n", " 'Galnt13', 'Frmpd4', 'Epha6', 'Dab1', 'Vamp2', 'Trpc4', 'Gabrb2',\n", " 'Snca', 'Kcnf1', 'Acsl4', 'Ppp3cb', 'Adgrl3', 'R3hdm1', 'Auts2',\n", " 'Pak3', 'Slc39a10', 'March6', 'Gnb2', 'Fut9', 'Lmo4', 'Exd2',\n", " 'Dapk1', 'Erc2', 'Nbea', 'Rab6a', 'Calm2', 'Hspa8', 'Cadm1',\n", " 'Ccser1', 'Anks1b', 'Kansl1', 'Ssbp2', 'Basp1', 'Prmt8', 'Sntg1',\n", " 'Abi2', 'Cntn1', 'Gria2', 'Nlk', 'Tox', 'Apba2', 'Ppp3ca',\n", " 'Sipa1l1', 'Mctp1', 'Ppp3r1', 'Kcnj3', 'Bcl11a', 'Sub1', 'Magi2',\n", " 'Mapt', 'Cntnap2', 'Adgrb3', 'Hecw1', 'Scn8a', 'Ctnnd2', 'Ncoa7',\n", " 'Camta1', 'Rock2', 'Ptprs', 'Morf4l2', 'Ndrg3', 'Brinp1', 'Cadps',\n", " 'Oxr1', 'Nlgn1', 'Ehbp1', 'Dpp10', 'Csmd2', 'Hprt', 'Unc80',\n", " 'Chsy3', 'Pls3', 'Ywhae', 'Serpini1', 'Hivep2', 'Gabra2', 'Ube2w',\n", " 'Kcnma1', 'Nap1l1', 'Mef2c', 'Cdc42', 'Psd3', 'Tspan7', 'Camkv',\n", " 'Chrm1', 'Rab26', 'Osbpl6', 'Zfp365', 'Nrxn1', 'Lrrc4c', 'Unc79',\n", " 'Atp6v1a', 'Pak7', 'Gabra4', 'Ywhag', 'Prkacb', 'Dlgap1', 'Trank1',\n", " 'App', 'Thrb', 'Cadm2', 'Sh3rf1', 'Nrxn3', 'Vgf', 'Capza2',\n", " 'Map1b', 'Mapk8', 'Cltc', 'Etv1', 'Unc5d', 'Celf5', 'Elavl4',\n", " 'Bcl11b', 'Rtn3', 'Cnih2', 'Kcnq3', 'Car10', 'Actr3', 'Dock3',\n", " 'Prkar1b', 'Herc1', 'Maged1', 'Slc22a17', 'Nckap1', 'Hnrnpk',\n", " 'Ppp1r9a', 'Tceal6', 'Cacna2d3', 'Glrb', 'Cttnbp2', 'Setbp1',\n", " 'Rims1', 'Fgf12', 'Dnajc6', 'Arf3', 'Agap2', 'Grm7', 'Robo2',\n", " 'Fgf14', 'Epha5', 'Adgrl1', 'Nrcam', 'Fam19a1', 'Efna5', 'Cplx2',\n", " 'Sptbn4', 'Gnao1', 'Grm5', 'Cacna2d1', 'Nck2', 'Adgrb2',\n", " '5730522E02Rik', 'Snap25', 'Cacna1e', 'Stmn4', 'Dlgap2', 'Gls',\n", " 'Btbd10', 'Grin2a', 'Matr3', 'Ctnna2', 'Nptn', 'Dlg3', 'Hsp90ab1',\n", " 'Grin2b', 'Psip1', 'Tcf4', 'Ppm1l', 'Cdk5r2', 'Syp', 'Nrg3',\n", " 'Epha7', 'Adgrb1', 'Homer1', 'Atxn10', 'Ptpra', 'Pacsin1',\n", " 'Sptan1', 'Ldb2', 'Runx1t1', 'Mdga2', 'Ppp2r2b', 'Myh10', 'Syne1',\n", " 'Trim32', 'Sqstm1', 'Otud7a', 'Atrnl1', 'Gpm6b', 'Ppp2ca',\n", " 'Mir124a-1hg', 'Fam171b', 'Stmn1', 'Nucks1', 'Nrg1', 'Slc35f1',\n", " 'Rap1gds1', 'Mlf2', 'Kcnab1', 'Flrt2', 'Itpr1', 'Chl1', 'Phactr1',\n", " 'Esyt2', 'Ssh2', 'Mtcl1', 'Srcin1', 'Trim9', 'Ptprd', 'Pcsk2',\n", " 'Kcnh5', 'Camk2b', 'Dmxl2', 'Caly', 'Ptms', 'Ank2', 'Dlc1',\n", " 'Sphkap', 'Mllt11', 'Crmp1', 'Hs3st4', 'Syngap1', 'Dlgap4',\n", " 'Gpm6a', 'Meis2', 'Slit3', 'Slc25a4', 'Hpca', 'Pdlim7', 'Necab1',\n", " 'Lingo1', 'Csmd1', 'Bex2', 'Osbpl1a', 'Arhgef9', 'Ywhaz',\n", " 'Neurod2', 'Dock4', 'Etv5', 'Ywhah', 'Slc17a7', 'Large1', 'Cacnb4',\n", " 'Kcnq5', 'Hcn1', 'Tceal5', 'Serbp1', 'Ube2e2', 'Atp6v0a1',\n", " 'Cacna1d', 'Ogfrl1', 'Pfn2', 'Dlg2', 'Gabra1', 'Atp6v1c1',\n", " 'Atp1a3', 'Cabp1', 'Tlcd2', 'Plxna4', 'Tcaf1', 'Tsc22d1', 'Adcy2',\n", " 'Fam155a', 'Gabrg3', 'Gabrg2', 'Syn2', 'Sptbn2', 'Thra', 'Ncdn',\n", " 'Syt13', 'Napb', 'Dnm1', 'Cpne8', 'Gabra5', 'Arpp21', 'Tpm3',\n", " 'Srrm2', 'Dmd', 'Tspan13', 'Nwd2', 'Snrpn', 'Prkcg', 'Gria3',\n", " 'Enc1', 'Ralyl', 'Herc3', 'Nkain2', 'Stxbp1', 'Mapre3', 'Npr3',\n", " 'Plcb1', 'Pgm2l1', 'Akap11', 'Kcnd2', 'Fam49b', 'Fhl2', 'Efhd2',\n", " 'Ppfia2', 'Tmsb4x', 'Usp46', 'Crtac1', 'Nol4', 'Syt7', 'Etl4',\n", " 'Lingo2', 'Lmtk2', 'Sprn', 'Cntn4', 'Map2k1', 'Pclo', 'Gdi1',\n", " 'Hpcal4', 'Serp2', 'St3gal5', 'Chn1', 'Khdrbs2', 'Efr3a', 'Thsd7b',\n", " 'Snn', 'Fry', 'Plekha5', 'Tagln3', 'Spink8', 'Kcnmb4', 'Celf1',\n", " 'Ttc9b', 'Eif1', 'Tomm70a', 'Dmtn', 'Cacna1a', 'B4galt6', 'Cnrip1',\n", " 'Macrod2', 'Madd', 'Eef1a2', 'Ssb', 'Pcdh7', 'Negr1', 'Dync1i1',\n", " 'Pak1', 'Nsf', 'Mff', 'Gng13', 'Ociad1', 'Pde10a', 'Lmo7',\n", " 'Rgs7bp', 'Ube2ql1', 'Rnf150', 'Itm2c', 'Cacnb3', 'Fnbp1l',\n", " 'Lrfn5', 'Camk2a', 'Kcnb1', 'Chst1', 'Camk2n1', 'Grik5', 'Svop',\n", " 'Rtn1', 'Akap8l', 'Arpc2', 'Lrba', 'Ptprn2', 'Itm2b', 'Atp6v1b2',\n", " 'Mycbp2', 'Abhd12', 'Psma1', 'Hs6st3', 'Mtpn', 'Rgs6', 'Camta2',\n", " 'Fscn1', 'Kctd16', 'Tenm2', 'Nptxr', 'Syn1', 'Phf24', 'Slc12a5',\n", " 'Cox6c', 'Slc1a1', 'D430041D05Rik', 'Camkk2', 'Chn1os3', 'Pkm',\n", " 'Tusc3', 'Epha4', 'Oxct1', 'Dkk3', 'Map9', 'Cpne6', 'Eif3e',\n", " 'Atp5a1', 'Dgkh', 'Calm1', 'Ddn', 'Celsr2', 'Shank2', 'Nptx1',\n", " 'Rapgef4', 'Grik3', 'Fxyd7', 'Olfm1', 'Ngef', 'Sorbs2', 'Arhgap26',\n", " 'Prnp', 'Sidt1', 'Fam126b', 'Pde4d', 'Adam22', 'Tenm4', 'Kcnip4',\n", " 'Hivep3', 'Ube2b', 'Ncald', 'Prickle1', 'Agbl4', 'Dnaja1', 'Stmn3',\n", " 'Tcf25', 'Pitpna', 'Unc13b', 'Tshz2', 'Thy1', 'Rap2b', 'Shank1',\n", " 'Dbn1', 'Sorl1', 'Syt11', 'C1qtnf4', 'Dynll1', 'Pfkp', 'Rasl11b',\n", " 'Hlf', 'Dgkg', 'Mapk10', 'Eif4g3', 'Ppp1r1a', 'Ckmt1',\n", " 'C230004F18Rik', 'Klhl2', 'Caln1', 'Synpo', 'Med26', 'Slit1',\n", " 'Msra', 'Actn1', 'Slc24a2', 'Syt16', 'Ap2b1', 'Elmod1', 'Nrgn',\n", " 'Myo5a', 'Rasgrp1', 'Tspan5', 'Cpne5', 'Tubb2a', 'Tubb5',\n", " 'Tmem158', 'Camk4', 'Nedd4l', 'Atpif1', 'Asic2', 'Cpne7', 'Kif5c',\n", " 'Coro1a', 'Snx10', 'Dgkz', 'Gpr158', 'Vsnl1', 'Ypel3', 'Prkce',\n", " 'Tmem181a', 'Atp2b2', 'Atp6ap2', 'Ap2s1', '2010300C02Rik', 'Uchl1',\n", " 'Aak1', 'Hk1', 'Sult4a1', 'R3hdm2', 'Snap91', 'Cyfip2', 'Lrrtm4',\n", " 'Ksr1', 'Mapk8ip2', 'Myt1l', 'Prkcb', 'Kcnh7', 'Ids', 'Foxg1',\n", " 'Dclk1', 'Plppr2', 'Cox6b1', 'Evi5', 'Tmsb10', 'Mapk1', 'Rbfox1',\n", " 'Rtf1', 'Tpi1', 'Idh3a', 'Mmp17', 'Lancl1', 'Miat', 'Ptprn',\n", " 'Actr2', 'Tspyl1', 'Selenow', 'Exoc5', 'Map2', 'Atp5g3', 'Gas7',\n", " 'Rasgrf1', 'Sgip1', 'Arfgef3', 'Ghitm', 'Ubb', 'Egfem1', 'Ksr2',\n", " 'Cers6', 'Micu3', 'Serinc1', 'Rapgefl1', 'Tnrc6c', 'Rasgef1b',\n", " 'Mef2d', 'Scai', 'Phyhip', 'Rheb', 'Prickle2', 'Arhgef25', 'Pde1a',\n", " 'Stum', 'Ext1', 'Actr3b', 'Chd5', 'Tmem132d', 'Dip2c', 'Sox5',\n", " 'Eif4a2', 'Fbxl16', 'Sptbn1', 'Gabbr2', 'Megf9', 'Gabarapl1',\n", " 'Rasgef1a', 'Nsg2', '4930481A15Rik', 'Junb', 'Sort1', 'Trim2',\n", " 'Fam135b', 'Ywhab', 'Mgst3', 'Frrs1l', 'Ephx4', 'Slc6a17',\n", " 'Fam49a', 'Ptk2', 'Arf1', 'Mkl2', 'Celf2', 'Trio', 'Gnaq', 'Lamp5',\n", " 'Ppia', 'Dtnb', 'Rnf14', 'Fars2', 'Sh3rf3', 'Klc1', 'Ryr2',\n", " 'Cdkl2', 'Rab2a', 'March1', 'Arpp19', 'Lpgat1', 'Clstn1', 'Kcnip3',\n", " 'Ptprg', 'Tpm1', 'Eno1', 'Ppp1r2', 'Gabrb3', '1700020I14Rik',\n", " 'Tub', 'Mal2', 'Pi4ka', 'Skp1a', 'Sun1', 'Rbfox3', 'Atp5j',\n", " 'Ndufa4', 'Rgs7', 'Sh3gl2', 'Actb', 'Ubqln2', 'Nell2', 'Arhgap44',\n", " 'Rtn4', 'Kcnh1', 'Ak5', 'Psma3', 'Stim2', 'Plk2', 'Add2', 'Vdac1',\n", " 'Hint1', 'Apbb1', 'Ptk2b', 'Mpped1', 'Synj1', 'Hsp90aa1', 'Gnb1',\n", " 'Nos1ap', 'Egr1', 'Syngr1', 'Agtpbp1', 'Ryr3', 'Calm3', 'Atp1a1',\n", " 'Ldha', 'Plppr4', 'Tmx4', 'Ppp2r1a', 'Sgcd', 'Brk1', 'Satb2',\n", " 'Galnt9', 'Dctn6', 'A830018L16Rik', 'Adcy1', 'Cobl', 'Gria1',\n", " 'Chrm3', 'Npy', 'Arl15', 'Kcnv1', 'Ntrk3', 'Plxna2', 'Amph',\n", " 'Atl1', 'Cap2', 'Cnih3', 'Diras2', 'Cadps2', 'Dusp14', 'Nuak1',\n", " 'Trim37', 'Rab15', 'Ppp2r2c', 'Kcnj4', 'Ankrd33b', 'Slc15a3',\n", " 'Nov', 'Ndst3', 'Pex5l', 'Nyap2', 'Mat2b', 'Arpc5', 'Sec14l1',\n", " 'Mmd', 'Snph', 'Fam81a', 'Unc13a', 'Vopp1', 'Celf4', 'Kcnq2',\n", " 'Ier5', 'Rmnd5b'], dtype=object),\n", " 'Bcl6(+)': array(['Nwd1', 'Nfia', 'Wdr17', 'Zbtb20', 'Nrxn1', 'Lsamp', 'Ptprz1',\n", " 'Atp1a2', 'Gpc5', 'Lama2', 'Appl2', 'Bcl6', 'Slc1a2'], dtype=object),\n", " 'Bnc2(+)': array(['Bmp7', 'Fmod', 'Atp1a2', 'Atp13a5', 'Alcam', 'Adam12', 'Igf2',\n", " 'Stra6', 'Trpm3', 'Sdk1', 'Rcsd1', 'Tbx15', 'Notch2', 'Slc26a2',\n", " 'Bmp6', '1500015O10Rik', 'Car13', 'Gjb2', 'Pear1', 'Slc6a20a',\n", " 'Mpzl2', 'Gm5860', 'Cdh1', 'Fn1', 'Slc13a4', 'Dapl1', 'Slc13a3',\n", " 'Ptgds', 'Prdm6', 'Lbp', 'Col6a2', 'Foxc2'], dtype=object),\n", " 'Cebpb(+)': array(['Neurod2', 'C1ql2', 'Olfm1', 'Ppp3ca', 'Hpca', 'Rfx3', 'Snca',\n", " 'Wasf1', 'Sema5a', 'Prox1', 'Calm2', 'Ppfia2', 'Bex2', 'Camk2b',\n", " 'Pter', 'C1ql3', '2010300C02Rik', 'Dsp', 'Ppp1r1a', 'Nrgn',\n", " 'Cpne6', 'Chn1', 'Dgkh', 'Dynll1', 'Rps7', 'Cebpb', 'Tmsb4x',\n", " 'Ncdn'], dtype=object),\n", " 'Cebpd(+)': array(['Fam163b', 'Dsp', 'Rfx3', 'Dock10', 'Ahcyl2', 'Nr3c2'],\n", " dtype=object),\n", " 'Dbp(+)': array(['Gpr162', 'Atp1a2', 'Kcnv1', 'Ptn', 'Slc1a2', 'Plec', 'Rorb',\n", " 'Dbp', 'Nr2f1', 'Clu', 'Fzd3', 'Itm2c', 'Olfm1', 'Pld3', 'Cdk5r2',\n", " 'Camkv', 'Cst3', 'Ttyh1', 'Apoe', 'Gpm6b', 'Fxyd7', 'Ddn',\n", " 'Shank1', 'Prnp', 'Itpka', 'Bsn', 'Bcan', 'Gja1', 'Synpo',\n", " 'Hpcal4', 'Slc1a3', 'Atp2b4', 'Napa', '1110008P14Rik', 'Tsc22d1',\n", " 'Klc1', 'Thra', 'Cck', 'Satb2', 'Lamp5', 'Nptn', 'Tbc1d9', 'Id2',\n", " 'Gapdh', 'Fam107a', 'Camk2n1', 'Cabp1', 'Cx3cl1', 'Slc2a1',\n", " 'Htra1', 'Stmn4', 'Psap', 'Sparcl1', 'Sirpa', 'Pcdhga1', 'Scg5',\n", " 'Gpr37l1', 'Pcsk1n'], dtype=object),\n", " 'Dlx1(+)': array(['Dlx1as', 'Dlx6os1', 'Cnr1', 'Gad1', 'Grip1', 'Tcf4', 'Maf',\n", " 'Dner', 'Nxph1', 'Dlx1', 'Rpp25', 'Adarb2', 'Erbb4', 'Gad2',\n", " 'Vstm2a', 'Synpr', 'Serpini1', 'Vip', 'Npy', 'Cck', 'Pcdha1',\n", " 'Slc6a1', 'Sst', 'Fxyd6', 'Slc32a1'], dtype=object),\n", " 'Ebf1(+)': array(['Acta2', 'Tcf7l2', 'Igfbp7', 'Cntnap2', 'Rbms3', 'Slc17a6',\n", " 'Atp13a5'], dtype=object),\n", " 'Egr1(+)': array(['Meg3', 'Satb1', 'Cdk17', 'Atp2b1', 'Stmn2', 'Cnksr2', 'Zfr',\n", " 'Syt1', 'Stxbp5l', 'Ttc3', 'Fbxw7', 'Lrrc7', 'Wasf1', 'Foxp1',\n", " 'Sept7', 'Cdkl5', 'Pja2', 'Nrn1', 'Vamp2', 'Snca', 'Ppp3cb',\n", " 'R3hdm1', 'Slc39a10', 'March6', 'Gnb2', 'Lmo4', 'Nbea', 'Rab6a',\n", " 'Calm2', 'Anks1b', 'Basp1', 'Prmt8', 'Abi2', 'Cntn1', 'Gria2',\n", " 'Nlk', 'Gabbr1', 'Cadm3', 'Apba2', 'Ppp3ca', 'Acvr1b', 'Ppp3r1',\n", " 'Kcnj3', 'Bcl11a', 'Sub1', 'Hecw1', 'Scn8a', 'Rock2', 'Ptprs',\n", " 'Ndrg3', 'Brinp1', 'Cadps', 'Oxr1', 'Nlgn1', 'Dpp10', 'Hprt',\n", " 'Ywhae', 'Serpini1', 'Hivep2', 'Kcnma1', 'Nap1l1', 'Mef2c', 'Psd3',\n", " 'Tspan7', 'Camkv', 'Chrm1', 'Sept11', 'Nrxn1', 'Unc79', 'Mark1',\n", " 'Atp6v1a', 'Gabra4', 'Ywhag', 'Prkacb', 'Dlgap1', 'App', 'Cadm2',\n", " 'Vgf', 'Egr3', 'Celf5', 'Nckap5', 'Rad23b', 'Rtn3', 'Kcnq3',\n", " 'Car10', 'Slc30a4', 'Prkar1b', 'Herc1', 'Nckap1', 'Hnrnpk',\n", " 'Ppp1r9a', 'Tceal6', 'Glrb', 'Rims1', 'Fgf12', 'Higd1a', 'Spred1',\n", " 'Arf3', 'Robo2', 'Adgrl1', 'Nrcam', 'Nrxn2', 'Gnao1', 'Cacna2d1',\n", " '5730522E02Rik', 'Snap25', 'Stmn4', 'Slitrk1', 'Gls', 'Trhde',\n", " 'Ovol2', 'Btbd10', 'Grin2a', 'Matr3', 'Nptn', 'Dlg3', 'Hsp90ab1',\n", " 'Grin2b', 'Tcf4', 'Cdk5r2', 'Syp', 'Adgrb1', 'Homer1', 'Sptan1',\n", " 'Trim32', 'Gpm6b', 'Ppp2ca', 'Mir124a-1hg', 'Fam171b', 'Stmn1',\n", " 'Rap1gds1', 'Mlf2', 'Itpr1', 'Phactr1', 'Ssh2', 'Trim9', 'Ptprd',\n", " 'Pcsk2', 'Fzd3', 'Camk2b', 'Caly', 'Ptms', 'Kif1a', 'Ank2',\n", " 'Mllt11', 'Crmp1', 'Syngap1', 'Dlgap4', 'Gpm6a', 'Slc25a4', 'Hpca',\n", " 'Ptn', 'Necab1', 'Lingo1', 'Csmd1', 'Bex2', 'Osbpl1a', 'Clip3',\n", " 'Ywhaz', 'Etv5', 'Ywhah', 'Slc17a7', 'Cacnb4', 'Tceal5', 'Pfn2',\n", " 'Ncan', 'Gabra1', 'Ildr2', 'Atp6v1c1', 'Atp1a3', 'Cabp1',\n", " 'Tsc22d1', 'Lrrc40', 'Gabrg2', 'Syn2', 'Sptbn2', 'Syt13', 'Napb',\n", " 'Dnm1', 'Tmem50a', 'Tmem151a', 'Arpp21', 'Tspan13', 'Nwd2',\n", " 'Snrpn', 'Prkcg', 'Gria3', 'Enc1', 'Iqsec2', 'Prkar1a', 'Stxbp1',\n", " 'Kcnv1', 'Plcb1', 'Pgm2l1', 'Fam49b', 'Efhd2', 'Usp46', 'Syt7',\n", " 'Clstn3', 'Pclo', 'Hpcal4', 'Serp2', 'St3gal5', 'Chn1', 'Efr3a',\n", " 'AI593442', 'Stx1b', 'Tagln3', 'Celf1', 'Ttc9b', 'Eif1', 'Tomm70a',\n", " 'Dmtn', 'Cacna1a', 'Ppp1r9b', 'Madd', 'Eef1a2', 'Negr1', 'Pak1',\n", " 'Nsf', 'Gng13', 'Pde10a', 'Rgs7bp', 'Ube2ql1', 'Itm2c', 'Cacnb3',\n", " 'Lrfn5', 'Camk2a', 'Kcnb1', 'Chst1', 'Pantr1', 'Camk2n1', 'Svop',\n", " 'Rtn1', 'Akap8l', 'Arpc2', 'B3galt2', '1190002N15Rik', 'Itm2b',\n", " 'Pitpnm3', 'Atp6v1b2', 'Abhd12', 'Hs6st3', 'Mtpn', 'Camta2',\n", " 'Fscn1', 'Tenm2', 'Nptxr', 'Syn1', 'Phf24', 'Cox6c', 'Camkk2',\n", " 'Chn1os3', 'Pkm', 'Nr2f1', 'Tusc3', 'Epha4', 'Oxct1', 'Dkk3',\n", " 'Atp5a1', 'Calm1', 'Celsr2', 'Shank2', 'Nptx1', 'Fxyd7', 'Olfm1',\n", " 'Ngef', 'Sorbs2', 'Arhgap26', 'Prnp', 'Sidt1', 'Adam22', 'Kcnip4',\n", " 'Pdp1', 'Epop', 'Ube2b', 'Ncald', 'Prickle1', 'Dnaja1', 'Stmn3',\n", " 'Tcf25', 'Pitpna', 'Igfbp4', 'Thy1', 'Shank1', 'Slc1a2', 'Nrsn1',\n", " 'Sorl1', 'Eif5a', 'Syt11', 'C1qtnf4', 'Dynll1', 'Pfkp', 'Rasl11b',\n", " 'Hlf', 'Tbc1d30', 'Mapk10', 'Dlk2', 'Ppp1r1a', 'Ckmt1', 'Synpo',\n", " 'Sgtb', 'Slc24a2', 'Nrgn', 'Myo5a', 'Rasgrp1', 'Tspan5', 'Tubb2a',\n", " 'Tubb5', 'Dlg1', 'Smim13', 'Camk4', 'Mir9-3hg', 'Atpif1', 'Asic2',\n", " 'Kif5c', 'Dgkz', 'Vsnl1', 'Ypel3', 'Hs3st2', 'Prkce', 'Tmem181a',\n", " 'Atp2b2', 'Atp6ap2', 'Ap2s1', '2010300C02Rik', 'Uchl1', 'Aak1',\n", " 'Sult4a1', 'Atp8a1', 'R3hdm2', 'Snap91', 'Cyfip2', 'Myt1l',\n", " 'Prkcb', 'Ids', 'Foxg1', 'Dclk1', 'Gfra2', 'Tmsb10', 'Mapk1',\n", " 'Tpi1', 'Idh3a', 'Miat', 'Ptprn', 'Actr2', 'Selenow', 'Kif5a',\n", " 'Gas7', 'Arfgef3', 'Ubb', 'Igfbp6', 'Micu3', 'Serinc1', 'Rasgef1b',\n", " 'Mef2d', 'Jph3', 'Arhgef25', 'Pde1a', 'Actr3b', 'Golga7b',\n", " 'Eif4a2', 'Fbxl16', 'Sptbn1', 'Gabbr2', 'Gabarapl1', 'Rasgef1a',\n", " 'Cds1', 'Tacc1', 'Nsg2', 'Junb', 'Sort1', 'Ywhab', 'Mgst3',\n", " 'Frrs1l', 'Ephx4', 'Rtn4', 'Unc13a', 'Tpm1', 'Nr4a1', 'Calm3',\n", " 'Tsnax', 'Ppme1', 'Eno2', 'Fam212b', 'Slc8a2', 'Cnih3', 'Baiap2',\n", " 'Ndrg4', 'Scamp5', 'Ppp2r2c', 'Syt4', 'Plxna2', 'Fabp3', 'Atp6ap1',\n", " 'Adcy1', 'Kcnh1', 'Fam49a', 'Rab15', 'Dctn2', 'Psma3', 'Celf2',\n", " 'Camk2g', 'Kctd17', 'Ctsb', 'Atp1a1', 'Fam131a', 'Copg2', 'Mmd',\n", " 'Nme1', '2010107E04Rik', 'Neurod6', 'Apbb1', 'Clstn1', 'Tyro3',\n", " 'Strn4', 'Actr1b', 'Cyb5a', 'Rbfox3', 'Opcml', 'Ldhb', 'Khdrbs3',\n", " 'Nat8l', 'Kcnj4', 'Mdh1', 'Mical2', 'Tmem38a', 'Tmem178',\n", " 'Sec14l1', 'Grin1', 'Atp1b1', 'Zbtb18', 'Arf1', 'Rprm', 'Lamp5',\n", " 'Ptk2', 'Cap2', 'Mkl2', 'Slc6a17', 'Diras2', 'Gabrb3', 'Fars2',\n", " 'Tbc1d9', 'Slc30a3', 'Arpp19', 'Pi4ka', 'Atp5j', 'Agtpbp1', 'Eno1',\n", " 'Ptk2b', 'Rangap1', 'Ppia', 'Gnaq', 'Eif4h', 'Ryr2', 'Rab6b',\n", " 'Tppp', '1700020I14Rik', 'Lancl2', 'Mat2b', 'Ppp2r1a', 'Fam81a',\n", " 'Vopp1', 'Pnrc1', 'Nell2', 'Sh3gl2', 'Celf4', 'Kcnq2', 'Nos1ap',\n", " 'Gnb1', 'Rgs7', 'Ppp5c', 'Napa', 'Cacng3', 'Ppm1k', 'Itpka',\n", " 'Klc1', 'Adap1', 'Tuba1a', 'Egr1', 'Slc25a3', 'Ndufa4', 'Scg5',\n", " 'Cx3cl1', 'Plk2', 'Ttc7b', 'Stx1a', 'Rap1gap2', 'Syngr1', 'Myl12b',\n", " 'Tmem59l', 'Brk1', 'Sept8', 'Spock1', 'Gapdh', 'Kifap3', 'Faim2',\n", " 'Sirpa', 'Ccl27a', 'Gda', 'Kalrn', 'Cfl1', 'Tbc1d24', 'Rnf187',\n", " 'Sncb', 'Tbr1', 'Arpc4', 'Rnf112', 'Clcn4', 'Tuba4a', 'Crip2',\n", " 'Atp6v1d', 'Car11', 'Eid1', 'Rph3a', 'Cyp46a1', 'Pcdha1', 'Pgbd5',\n", " 'Tuba1b', 'Grina', 'Hras', 'Atp2a2', 'Ddx5', 'Satb2', 'Flrt2',\n", " 'Efna5', 'Dlgap3', 'Cux2', 'Kctd1', 'Galnt9', 'Tshz3', 'Pcdh10',\n", " 'Rorb', 'Ddit4l', 'Kcnmb4', 'Pak7', 'Kcnt2', 'Dact2', 'Ankrd33b'],\n", " dtype=object),\n", " 'Egr3(+)': array(['Tanc2', 'Meg3', 'Slitrk4', 'Cdk17', 'Atp2b1', 'Cnksr2', 'Syt1',\n", " 'Ttc3', 'Fbxw7', 'Wasf1', 'Tceal3', 'Cdkl5', 'Pja2', 'Nrn1',\n", " 'Vamp2', 'Snca', 'Ppp3cb', 'Slc39a10', 'Lmo4', 'Dapk1', 'Erc2',\n", " 'Nbea', 'Rab6a', 'Calm2', 'Anks1b', 'Basp1', 'Prmt8', 'Abi2',\n", " 'Gria2', 'Gabbr1', 'Cadm3', 'Apba2', 'Ppp3ca', 'Sipa1l1', 'Acvr1b',\n", " 'Ppp3r1', 'Kcnj3', 'Sub1', 'Ptprs', 'Ndrg3', 'Brinp1', 'Nlgn1',\n", " 'Ywhae', 'Kcnma1', 'Mef2c', 'Cdc42', 'Tspan7', 'Camkv', 'Chrm1',\n", " 'Pdcd4', 'Nrxn1', 'Atp6v1a', 'Ywhag', 'Prkacb', 'Map1a', 'Dlgap1',\n", " 'App', 'Cadm2', 'Nrxn3', 'Vgf', 'Zfand5', 'Capza2', 'Egr3',\n", " 'Celf5', 'Nckap5', 'Cnih2', 'Anp32a', 'Car10', 'Prkar1b',\n", " 'Slc22a17', 'Nckap1', 'Hnrnpk', 'Ppp1r9a', 'Arf3', 'Shisa7',\n", " 'Nrcam', 'Cplx2', 'Grm5', 'Cacna2d1', 'Adgrb2', 'Snap25',\n", " 'Cacna1e', 'Stmn4', 'Dlgap2', 'Gls', 'Btbd10', 'Grin2a', 'Matr3',\n", " 'Sorcs3', 'Nptn', 'Dlg3', 'Hsp90ab1', 'Tcf4', 'Cdk5r2', 'Syp',\n", " 'Adgrb1', 'Homer1', 'Sptan1', 'Syne1', 'Trim32', 'Sqstm1',\n", " 'Ppp2ca', 'Fam171b', 'Stmn1', 'Mlf2', 'Itpr1', 'Dpf1', 'Phactr1',\n", " 'Pcsk2', 'Fzd3', 'Camk2b', 'Dmxl2', 'Caly', 'Ptms', 'Mllt11',\n", " 'Crmp1', 'H2afz', 'Syngap1', 'Dlgap4', 'Gpm6a', 'Slit3', 'Hpca',\n", " 'Ptn', 'Lingo1', 'Csmd1', 'Bex2', 'Osbpl1a', 'Arhgef9', 'Ywhaz',\n", " 'Ywhah', 'Slc17a7', 'Tceal5', 'Serbp1', 'Ogfrl1', 'Dlg2', 'Ppp1cb',\n", " 'Prpf39', 'Gabra1', 'Atp6v1c1', 'Cabp1', 'Pter', 'Sertm1',\n", " 'Tsc22d1', 'Fkbp3', 'Ccsap', 'Cux2', 'Lrrc40', 'Syn2', 'Sptbn2',\n", " 'Thra', 'Ncdn', 'Napb', 'Dnm1', 'Arpp21', 'Tpm3', 'Grasp', 'Snrpn',\n", " 'Prkcg', 'Gria3', 'Enc1', 'Ralyl', 'Herc3', 'Stxbp1', 'Kcnv1',\n", " 'Plcb1', 'Pgm2l1', 'Fhl2', 'Efhd2', 'Tmsb4x', 'Klhl23', 'Syt7',\n", " 'Pclo', 'Kcnip2', 'Hpcal4', 'Serp2', 'St3gal5', 'Chn1', 'Snn',\n", " 'AI593442', 'Celf1', 'Ttc9b', 'Eif1', 'Dmtn', 'Dcaf7', 'Eef1a2',\n", " 'Negr1', 'Nsf', 'Gng13', 'Ociad1', 'Pea15a', 'Ube2ql1', 'Itm2c',\n", " 'Cacnb3', 'Camk2a', 'Kcnb1', 'Chst1', 'Camk2n1', 'Grik5', 'Rtn1',\n", " 'Arpc2', 'Atp6v1b2', 'Ddit4l', 'Mtpn', 'Camta2', 'Fscn1', 'Tenm2',\n", " 'Nptxr', 'Syn1', 'Phf24', 'Slc12a5', 'Cox6c', 'D430041D05Rik',\n", " 'Camkk2', 'Chn1os3', 'Pkm', 'Nr2f1', 'Tusc3', 'Epha4', 'Dkk3',\n", " 'Cpne6', 'Calm1', 'Rilpl1', 'Ddn', 'Shank2', 'Nptx1', 'Fxyd7',\n", " 'Olfm1', 'Ngef', 'Shank1', 'Rtn4', 'Unc13a', 'Tpm1', 'Ncald',\n", " 'Prnp', 'Thy1', 'Eif5a', 'Calm3', 'Ubb', 'Vsnl1', 'Scamp5',\n", " 'Ap2m1', 'Plppr4', 'Nsg2', 'Baiap2', '4930481A15Rik', 'Ndrg4',\n", " 'Ppp2r2c'], dtype=object),\n", " 'Egr4(+)': array(['Atp2b1', 'Syt1', 'Snca', 'Arpp21', 'Dlgap1', 'Camkv', 'Cnksr2',\n", " 'Ywhaz', 'Snap25', 'Dclk1', 'Homer1', 'Lmo4', 'Grin2b', 'Ppp3ca',\n", " 'Mef2c', 'Syp', 'Dnm1', 'Slc17a7', 'Calm2', 'Sub1', 'Gpr22',\n", " 'Ensa', 'Camk2n1', 'Nrgn', 'Cdk5r2', 'Itm2c', 'Gria2'],\n", " dtype=object),\n", " 'Elk1(+)': array(['Snca', 'Snap25', 'Ppp3ca', 'Camk2b', 'Camk2n1', 'Nckap1', 'Gpm6a',\n", " 'Ptms', 'Itm2c', 'Slc17a7', 'Hsp90ab1', 'Tmsb4x', 'Ndrg4', 'Ddn',\n", " 'Elk1', 'Bex2', 'Arpc2', 'Calm3', 'Nrgn', 'Rtn1', 'Atp5g1',\n", " 'Olfm1', 'Syp', 'Atp1a1', 'Enc1', 'Snrpn', 'Ncdn', 'Calm2', 'Chgb'],\n", " dtype=object),\n", " 'En1(+)': array(['Uncx', 'Pou3f2', 'Foxa2', 'Gucy2c', 'Ankrd34b', 'Chrnb3', 'Kcns3',\n", " 'Oprk1', 'Ctxn2', 'Foxa1', 'Col25a1', 'Sv2c', 'Ddc', 'Serpine2',\n", " 'Fam204a', 'Grip2', 'Klhl13', 'Klhl1', 'Aldh1a1', 'Asb4',\n", " 'C130021I20Rik', 'Chrna4', 'Grb10', 'B630019K06Rik', 'Lmx1b',\n", " 'Tmem255a', 'Ret', 'Ndnf', '1700001C19Rik', 'Slc6a3', 'En1',\n", " 'Ntsr1', 'Th', 'Ntn1', 'Lix1', 'Vat1l', 'Trpc6', 'Iqcj', 'Pbx3',\n", " 'Slc18a2', 'Zdbf2', 'Drd2', 'Nr4a2', 'Fgf13', 'Kcnd3', 'Zfhx3',\n", " 'Dlk1', 'Apba1', 'Nwd2', 'Plcxd2', 'Zcchc12', 'Chrna6', 'Fam184a',\n", " 'Lbh', 'Slc10a4', 'AW551984'], dtype=object),\n", " 'Ets2(+)': array(['Atp2b1', 'Syt1', 'Ttc3', 'Vamp2', 'Snca', 'Rab6a', 'Calm2',\n", " 'Basp1', 'Gria2', 'Ppp3ca', 'Ppp3r1', 'Sub1', 'Snap25', 'Prkar1b',\n", " 'Camk2b', 'Chst1', 'Ptms', 'Ncald', 'Cacnb3', 'Slc17a7', 'Enc1',\n", " 'Bex2', 'Dnm1', 'Rgs7bp', 'Rtn1', 'Camk2n1', 'Vsnl1', 'Gpm6a',\n", " 'Lamp5', 'Nrgn', 'Ets2', 'Atp1a1', 'Tmsb4x', 'Cdk5r1', 'Chn1',\n", " 'Tubb2a'], dtype=object),\n", " 'Etv1(+)': array(['Tollip', 'Prss12', 'Chst8', 'Ndst4', 'Tmem200a', 'Igfbp4',\n", " 'Man1a'], dtype=object),\n", " 'Etv5(+)': array(['Meg3', 'Vamp2', 'Syt1', 'Dlgap1', 'Slc17a7', 'Adgrb3', 'Gpm6a'],\n", " dtype=object),\n", " 'Foxa1(+)': array(['AW551984', '1700001C19Rik', 'Ndnf', 'Chrna4', 'Rab3c', 'Aldh1a1',\n", " 'Chrna6', 'Fam167a', 'Drd2', 'Lmx1b', 'Sv2c', 'Ddc', 'Foxa1',\n", " 'Slc18a2', 'Chrnb3', 'Ret', 'Pbx3', 'Th', 'Dlk1', 'Aldh1a7',\n", " 'Slc6a3'], dtype=object),\n", " 'Foxa2(+)': array(['Chrnb3', 'Foxa2', 'Ebf3', 'Gm2694', 'Ebf2', 'Ntn1'], dtype=object),\n", " 'Foxc2(+)': array(['Lmx1b', 'Zic2', 'Zic4', 'Ahnak', 'Bgn', 'Gjb6', 'Msx1', 'Igfbp5',\n", " 'Fn1', 'Prelp', 'Tgfbi', 'S100a11', 'Tgfbr3', 'Trpm3', 'Gm5860',\n", " 'Nfatc4', 'Rspo3', 'Slc26a7', 'Bmp7', 'Aph1a', 'Slc13a4',\n", " 'Slc26a2', 'Anxa3', 'Car13', 'Fzd2', 'Wfikkn2', 'Mgp', 'Col5a2',\n", " 'Tns2', 'Bmp4', 'Igfbp6', 'Bnc2', 'Tspan8', 'Six2', 'Cmss1',\n", " 'Pkd2', 'Tbx15', 'Serpind1', 'Col1a2', 'Islr', 'Cped1', 'Aldh1a2',\n", " 'Hmgcs2', 'Rbp1', 'Ptgds', 'Slc47a1', 'Foxc2', 'Slc6a13',\n", " '1500015O10Rik', 'Tnfrsf11b', 'Slc6a12', 'Fxyd5', 'Lypd2',\n", " 'Slc38a2', 'Slc16a9', 'Foxc1', 'Smoc1', 'Prg4', 'Alpl', 'Slco4a1',\n", " 'Adamtsl3', 'Ifitm2', 'Fgl2'], dtype=object),\n", " 'Foxd2(+)': array(['Bdh2', 'Vsx1', 'Aldh1a2', 'Slc22a6', 'Slc6a12', 'Foxd1',\n", " 'Tnfrsf11b', 'Osr1'], dtype=object),\n", " 'Gata3(+)': array(['Gata3', 'Gad1', 'Tcf7l2', 'Plp1', 'Lhx1os', 'Gad2', 'Scn9a',\n", " 'Six3', 'Pld5', 'Slc32a1', 'Chrm2', 'Pbx3'], dtype=object),\n", " 'Glis3(+)': array(['Fut8', 'Dtna', 'Nr3c2', 'Smarca2', 'Rfx3', 'Maml2', 'Slc4a4',\n", " 'Dab1', 'Nlgn1', 'Acsl3', 'Msi2', 'Grm3', 'Rora', 'Cadm1', 'Ncam1',\n", " 'Garem1', 'Gria2', 'Gli3', 'Tead1', 'Myo6', 'Nfia', 'Tmem164',\n", " 'Mdga2', 'Zfp217', 'Chd7', 'Zeb1', 'Diaph2', 'Nrcam', 'Adgrb3',\n", " 'Gabra2', 'Pip5k1b', 'Abi1', 'Zfpm2', 'Prkg1', 'Rgs20', 'Negr1',\n", " 'Pcdh9', 'Cadm2', 'Nfib', 'Plekhg1', 'Farp1', 'Ptchd4', 'Glis3',\n", " 'Mapk4', 'Gpc6', 'Hectd2', 'Ptprz1', 'Auts2', 'Macrod2', 'Ppfia2',\n", " 'Grik2', 'Nrxn1', 'Ctnnd2', 'Csgalnact1', 'Trps1', 'Setbp1',\n", " 'Plcb1', 'Paqr8', 'Magi2', 'Npas3', 'Tnfrsf19', 'Wdr17', 'Sox6',\n", " 'Syne1', 'Dennd1a', 'Cttnbp2', 'Sorbs1', 'Kirrel3', 'Prkd1', 'Qk',\n", " 'Pde8b', 'Frmd4a', 'Gpc5', 'Ston2', 'Nebl', 'Celf2', 'Dgkh',\n", " 'Rorb', 'Prox1', 'Tjp1', 'Arhgef26', 'Gabrb1', 'Gja1', 'Slc1a2',\n", " 'Ptprt', 'Tcf4', 'Phka1', 'Pitpnc1', 'Pnisr', 'Dock4', 'Zbtb16',\n", " 'Ccdc85a', 'Tnik', 'Fmn2', 'Tmem108', 'Macf1', 'Iqgap2', 'Adcy7',\n", " '4930402H24Rik', 'Kcnn2', 'Trpm3', 'Nedd4l', 'Gli2', 'Pde7b',\n", " 'Ryr2', 'Appl2', 'Mcc', 'Lrp1b', 'A330033J07Rik', 'Carmil1',\n", " 'Dlg2'], dtype=object),\n", " 'Hivep2(+)': array(['Kmt2e', 'Atp2b1', 'Slc39a10', 'Cdk17', 'Satb1', 'Lrrc7',\n", " 'Pafah1b1', 'Atf2', 'Akt3', 'Cnksr2', 'Galnt13', 'Hivep2',\n", " 'Smarca2', 'Fbxw7', 'Rims2', 'Ube3a', 'Man1a', 'Slitrk5', 'Lingo2',\n", " 'Sgcz', 'Tanc2', 'Kat6b', 'Stag1', 'Sept7', 'Adgrl3', 'Kansl1',\n", " 'Mef2a', 'Zfp385b', 'Slitrk4', 'Zfp804a', 'Ttc3', 'Enox1', 'Syt1',\n", " 'Stmn2', 'Atxn1', 'Stxbp5l', 'Runx1t1', 'Grid2', 'Pja2', 'Zfr',\n", " 'Ppp3cb', 'Ccser1', 'Mapk8', 'Ntng1', 'Mctp1', 'Hook1', 'Cdh2',\n", " 'Dlgap1', 'Basp1', 'Ncoa7', 'Btbd10', 'Fut9', 'Dpp10', 'Nap1l1',\n", " 'Slc16a10', 'Cacna2d1', 'Dab1', 'Nlgn1', 'Numb', 'Car10', 'Cdh8',\n", " 'Fgf12', 'Fbxo11', 'Trpc4', 'Grm3', 'Pparg', 'Usp32', 'Cdkl5',\n", " 'Pam', 'Arap2', 'Sh3rf1', 'Rora', 'Osbpl6', 'Kif1b', 'Thrb',\n", " 'Arhgap21', 'Camk1d', 'R3hdm1', 'Nbea', 'Ralyl', 'Anks1b', 'Efna5',\n", " 'Il1rapl2', 'Sptan1', 'Foxp1', 'Cadm1', 'Wasf1', 'Ppp1r12a',\n", " 'Grm8', 'Xkr6', 'Ncor1', 'Lyst', 'Frmpd4', 'Sipa1l1', 'Prr16',\n", " 'Kcnt2', 'Fam19a2', 'March6', 'Gria4', 'Mllt3', 'Gria2', 'Unc5d',\n", " 'Ssbp2', 'App', 'Matr3', 'Chsy3', 'Hecw2', 'Ube2w', 'Dok6', 'Tox',\n", " 'Sntg1', 'Lrfn5', 'Ppp1r9a', 'Runx2', 'Mdga2', 'Baz2b', 'Arl15',\n", " 'Snca', 'Tmem200a', 'Calm2', 'Tceal3', 'Ldlrad4', 'Alcam',\n", " 'Diaph2', 'Kctd1', 'Cdh11', 'Nckap1', 'Chl1', 'Nrcam', 'Gabrb2',\n", " 'Ppm1l', 'Arpp21', 'Oxr1', 'St6gal2', 'Epha6', 'Ppp3ca', 'Unc80',\n", " 'Cadps', 'Apba2', 'Adgrb3', 'Gabra2', 'Gabbr1', 'Npas2',\n", " '5730522E02Rik', 'Morf4l2', 'Cadm3', 'Capza2', 'Rock2', 'Fzd3',\n", " 'Trhde', 'Ube2k', 'Hspa8', 'Flrt2', 'Abi1', 'Trank1', 'Hprt',\n", " 'Gabra4', 'Erc2', 'Rab6a', 'Cux1', 'Abi2', 'Enc1', 'Hecw1',\n", " 'Cacna2d3', 'Cyfip1', 'Cdc42', 'Kcnc2', 'Prkacb', 'Homer1',\n", " 'Ube2e2', 'Nkain2', 'Pdp1', 'Herc1', 'Gabra5', 'Prkg1', 'Lrrc8b',\n", " 'Cnot2', 'Cdc42se2', 'Prickle1', 'Ahi1', 'Grm5', 'B3gat1', 'Kcnq3',\n", " 'Myh10', 'Man1a2', 'Large1', 'Psip1', 'Gnas', 'Negr1', 'Rgs17',\n", " 'Phf20l1', 'Cltc', 'Cdh12', 'Mir124-2hg', 'Cntnap2', 'Cntn1',\n", " 'Efnb2', 'Snap25', 'Brinp3', 'Syt14', 'Nol4', 'Pcdh9', 'Cadm2',\n", " 'Map1b', 'Fnbp1l', 'Syndig1', 'Nkain3', 'Lmo4', 'Gls', 'Mef2c',\n", " 'Robo2', 'Cd47', 'Mlf2', 'Nfib', 'Zfp365', 'Pdcd4', 'Bcl11a',\n", " 'Hcn1', 'Atrnl1', 'Tenm4', 'Pls3', 'Farp1', 'Rap1gds1', 'Myrip',\n", " 'Ptchd4', 'Magi1', 'Grip1', 'Kif21a', 'Kcnj3', 'Rasal2',\n", " '9530059O14Rik', 'Dock3', 'Ssh2', 'Gpc6', 'Xkr4', 'Arid5b',\n", " 'Sestd1', 'Stmn1', 'Elavl4', 'Rad23b', 'Sub1', 'Tspan7', 'March1',\n", " 'Atl1', 'Ralgapa2', 'Nrg3', 'Mapt', 'Nin', 'Kcnmb4', 'Auts2',\n", " 'Macrod2', 'Tiam2', 'Ctnna2', 'Kif5c', 'Pak7', 'Frmd6', 'Ppfia2',\n", " 'Plxna4', 'Nucks1', 'Gnao1', 'Map9', 'Rgl1', 'Akap11', 'Slc23a2',\n", " 'Atp6v1a', 'Dnaja1', 'Man2a1', 'Samd5', 'Ehbp1', 'Camta1',\n", " 'Dennd5b', 'Amph', 'Cpne8', 'Dmxl2', 'Grik2', 'Adcy8', 'Asap2',\n", " 'Map3k5', 'Ndrg3', 'Spred1', 'Pde10a', 'Snap91', 'Nrxn1',\n", " 'Osbpl1a', 'Rims1', 'Zfp706', 'Sobp', 'Ctnnd2', 'Eml5', 'Nrn1',\n", " 'Prmt8', 'Nckap5', 'Rtn3', 'Prkar1a', 'Ywhae', 'Zfp804b', 'Acvr1b',\n", " 'Ptpra', 'Spcs3', 'Dclk1', 'Kcnq5', 'Ppp3r1', 'Agtpbp1', 'Fstl4',\n", " 'Cacnb2', 'Setbp1', 'Grm7', 'Tcaf1', 'Ext1', 'Elmod1', 'Arf3',\n", " 'Etv1', 'C130071C03Rik', 'Cds1', 'Atp8a1', 'Lrrc4c', 'Zbtb18',\n", " 'Trim9', 'Gabrg3', 'Plcb1', 'Gnb2', 'Fgf14', 'Ywhaz', 'Srrm2',\n", " 'Dync1i1', 'Mtcl1', 'Hs6st3', 'Khdrbs2', 'Magi2', 'Rgs6', 'Celf1',\n", " 'Ptprk', 'C1ql3', 'Bex2', 'Sept11', 'Pak3', 'Meg3', 'Brinp1',\n", " 'Mapre3', 'Tceal6', 'Tsc22d1', 'Epha7', 'Pcsk2', 'Olfm2', 'Caln1',\n", " 'Sptbn2', 'Kcnd2', 'Ppm1h', 'Tnrc6c', 'Napb', 'Wdr17', 'Csmd2',\n", " 'Dlgap2', 'Mef2d', 'Fam19a1', 'Grin2b', 'Rasgef1b', 'Actr3',\n", " 'Kcnv1', 'Mtus2', 'Ptpn5', 'Gnaq', 'Sbf2', 'Scn8a', 'Fam155a',\n", " 'Mkl1', 'Syne1', 'Unc79', 'Necab1', 'Arntl', 'Arf1', 'Fam126b',\n", " 'Mkl2', 'Ptprd', 'Itpr1', 'Phactr1', 'Ncoa1', 'Dennd1a', 'Immp2l',\n", " 'Cttnbp2', 'Dpy19l1', 'Rap2b', 'Herc3', 'Park2', 'Zcchc7',\n", " 'Sorbs1', 'Epha5', 'Tshz3', 'Kirrel3', 'B4galt6', 'Gm20754',\n", " 'Esyt2', 'Atp5g3', 'Grm1', 'Nlk', 'Esrrg', 'Sms', 'Glrb',\n", " 'Prkar1b', 'Cdh6', 'Pfn2', 'Ppp2ca', 'Cplx2', 'Adcy2', 'Asap1',\n", " 'Pi4ka', 'Cacna1e', 'Mtpn', 'Ncam2', 'Pfkp', 'Rfx7', 'Robo1',\n", " 'Dlgap3', 'Gnl3l', 'Ptk2', 'Htr1f', 'Ociad1', 'Nwd2', 'Grin2a',\n", " 'Fhl2', 'Clasp2', 'Ola1', 'Gpm6b', 'Pan3', 'Arhgap26', 'Gucy1a2',\n", " 'Ank2', 'Slc35f1', 'C2cd5', 'Gsk3b', 'Lmo7', 'Nos1ap', 'Kcnh7',\n", " 'Vamp2', 'Serbp1', 'Pde8b', 'Pgm2l1', 'Rtn1', 'Frmd4a', 'Cntn4',\n", " 'Pvt1', 'Slc35f4', 'Osbpl3', 'Evi5', 'Ust', 'Calm1', 'Rtf1',\n", " 'Serpini1', 'Efr3a', 'Synj1', 'Nrg1', 'Actr2', 'Nebl', 'Pclo',\n", " 'Fbxo34', 'Dapk1', 'Pfkm', 'Pkm', 'Celf2', 'Sorcs3', 'Slitrk1',\n", " 'Gabra1', 'Adgrl1', 'Dgkh', 'Rorb', 'Lmtk2', 'Mbnl2', 'Hsp90ab1',\n", " '2010300C02Rik', 'Ube2b', 'Rtn4', 'Myo16', 'Chrm3', 'Slc24a2',\n", " 'Hs3st4', 'Scai', 'Serp2', 'Arhgap44', 'Fars2', 'Snph', 'Map2',\n", " 'Ncald', 'Ywhag', 'Ttc14', 'Abcc5', 'Atp6v1b2', 'Dst', 'Vps13b',\n", " 'Kcnab1', 'Tbc1d30', 'Appl1', 'Cacnb4', 'Lin7a', 'Chrm1', 'Ywhab',\n", " 'Trim37', 'Foxg1', 'Nrxn3', 'Klhl29', 'Cntn5', 'Gabrb1', 'Epha4',\n", " 'Clstn2', 'Arnt2', 'Dmd', 'Gnaz', 'Ppp1r2', 'Caly', 'Rasl11b',\n", " 'Slc2a13', 'Mapk1', 'Camkk2', 'Ppp2r2b', 'Gabrg2', 'Ywhah',\n", " 'Ptprt', 'Tcf4', 'Rnf14', 'Cers6', 'Map2k1', 'Prnp', 'Abr',\n", " 'Myo5a', 'Plekha5', 'Atp6v1c1', 'Kcnb1', 'Nptn', 'Dscaml1',\n", " 'Lpgat1', 'Set', 'Megf9', 'Lrrtm1', 'Ankhd1', 'Hdac4', 'Micu3',\n", " 'Pnisr', 'Kcnh1', 'Acap2', 'Abhd12', 'Plk2', 'Otud7a', 'Dock4',\n", " 'Usp46', 'Sh3gl2', 'Cap2', 'Exoc5', 'Zfp697', 'Tmx4', 'Mat2b',\n", " 'Tnik', 'Fmn2', 'Kcnip3', 'Nae1', 'Rnf150', 'Camk4', 'Mllt11',\n", " 'Rbfox1', 'AI593442', 'Tmem108', 'Adam22', 'Agbl4', 'Hace1',\n", " 'Macf1', 'Kitl', 'Cacna1c', 'Ildr2', 'Chn1', 'Nsf', 'Oxct1',\n", " 'Nuak1', 'Sorcs1', 'Dnajc6', 'Arfgef3', 'Kcnn2', 'Sun1', 'Slc4a3',\n", " 'Tusc3', 'Snrpn', 'Ptms', 'Lancl1', 'Gpm6a', 'Trio', 'Rab15',\n", " 'Spata7', 'Nedd4l', 'Bcl11b', 'Cyfip2', 'Cdk14', 'Galnt9',\n", " '1700020I14Rik', 'Meis2', 'Acvr2a', 'Pde7b', 'Csmd1', 'Nmnat2',\n", " 'Trim32', 'Pten', 'Etv5', 'Apba1', 'Mmp16', 'Mast2', 'Cpne4',\n", " 'Phf24', 'Dip2c', 'Etnk1', 'Gng13', 'Nme1', 'Ryr2', 'Cnih3',\n", " 'Tomm70a', 'Camkv', 'Zdhhc14', 'Med13l', 'Lrp1b', 'Tspoap1',\n", " 'Dynll1', '2900055J20Rik', 'Syn2', 'Rab2a', 'Slc6a17', 'Rab26',\n", " 'Syt13', 'Vti1b', 'Arhgap33', 'Sphkap', 'Rgs7', 'Ngef', 'Fry',\n", " 'Dlg2', 'Pbx1', 'Fras1', 'Pcdh7', 'Efhd2', 'Ogfrl1', 'Sybu',\n", " 'Actn1', 'Nell2', 'Ctnna3', 'Kcnh5', 'Miat', 'Dyrk2', 'Rgs7bp',\n", " 'Fam49a', 'Plxna2', 'Ddit4l', 'Snx10', 'Ak5', 'Frrs1l',\n", " 'Gabarapl1', 'Ssb', 'C230004F18Rik', 'Snn', 'Tspan13', 'Pde4dip',\n", " 'Lamp5', 'A830018L16Rik', 'Apbb1', 'Hdac9', 'Akap8l', 'Ndufa4',\n", " 'Dlg3', 'Mycbp2', 'Arhgef9', 'Ptpn3', 'Camk2g', 'Crmp1', 'Rapgef4',\n", " 'Ppia', 'Syn1', 'Adgrb1', 'Prickle2', 'Kcnh3', 'Dtnb', 'Hivep3',\n", " 'Tmem191c', 'Arid1b', 'Calb1', 'Smyd3', 'Kctd16', 'Dock9', 'Nrsn1',\n", " 'Syt7', 'Myl12b', 'Msra', 'Vopp1', 'Slc17a7', '2010111I01Rik',\n", " 'Dpp6', 'Fam193a', 'Serinc1', 'Ntrk2', 'Cacna1d', 'Fhod3',\n", " 'Atp5a1', 'Dgkb', 'Kcnma1', 'Pkd1', 'Fam49b', 'Arpp19', 'Cdh10',\n", " 'Vgf', 'Agap2', 'Hpca', 'Ckmt1', 'Ano4', 'Mical2', 'Atp5j',\n", " 'Adam23', 'R3hdm2', 'Fam135b', 'Dgkg', 'St3gal5', 'Tia1', 'Slit3',\n", " 'Gnb1', 'Lrrtm3', 'Ap2a2', 'Brk1', 'Sidt1', 'Sh3rf3', 'Gm1976',\n", " 'Shisa9', 'Prkce', 'Ptprs', 'Egfem1', 'Mir9-3hg', 'Pcdha1',\n", " '3110039M20Rik', 'Tspan5', 'Slit2', 'Ubb', 'Cadps2', 'Ncan',\n", " 'Unc13b', 'Rab12', 'Lrrc40', 'Dennd6b', 'Slc22a17', 'St13', 'Ank',\n", " 'Tceal5', 'Prkca', 'Pde4d', 'Pacsin1', 'Neurod2', 'Srcin1',\n", " 'Ube3c', 'N4bp2l2', 'Madd', 'Nr2f1', 'Cnrip1', 'Pde1a', 'Arpc2',\n", " 'Ptprj', 'Sec14l1', 'Psma1', 'Add2', 'Tspyl1', 'Syt16', 'Fxyd7',\n", " 'Ly6h', 'Mapk10', 'Cd34', 'Cdh18', 'Xist', 'Junb', 'Asph', 'Astn2',\n", " 'A330008L17Rik', 'Cit', 'Hsp90aa1', 'Psma3', 'Sgip1', 'Fam171b',\n", " 'Mink1', 'Pde4a', 'Ndst3', 'Celf5', 'Ogt', 'Mir124a-1hg', 'Coro1a',\n", " 'Nrgn', 'Galnt18', 'Ppp2r1a', 'Synpo', 'Kcnj6', 'Vsnl1',\n", " 'Tmem132d', 'Shank1', 'Rasgrp1', 'Actr3b', 'Gabrb3', 'C1qtnf4',\n", " 'Sv2b', 'Dlg4', 'Ndufs4', 'Iqsec2', 'Nov', 'Zmat4', 'Dcc', 'Tpm1',\n", " 'D430041D05Rik', 'Gda', 'Rasgef1a', 'Slc25a3', 'Sept8', 'Nav2',\n", " 'Sptbn4', 'Gabbr2', 'Pex5l', 'Nsg2', 'Ldha', 'Rasgrf1', 'Kcna2',\n", " 'Mkx', 'Sesn1', 'Samd12', 'Scn2b', 'Tsnax', 'Sel1l3', 'Vps29',\n", " 'Ksr2', 'Ano3', 'Eif4g3', 'Ksr1', '9330182L06Rik', 'Fcho1',\n", " 'Tubb2a', 'Chd5', 'Sort1', 'Svop', 'Hk1', 'Thy1', 'Gramd1b',\n", " 'Ube2ql1', 'D630045J12Rik', 'Me3', 'Gria3', 'Hsph1', 'Cntnap5a',\n", " 'Prkag2', 'Hspa12a', 'Prkcg', 'Egr3'], dtype=object),\n", " 'Jun(+)': array(['Crlf1', 'C1ql2', 'Tspan18', 'Slc39a6', 'Car12', 'Tanc1', 'Ehd3',\n", " 'Tdo2', 'Neurod1', 'Prdm8', 'Jun', 'Ptma', 'Sema5a', 'Bcl11b',\n", " 'Ak5', 'Pgbd5', 'Fam19a2', 'Tiam1', 'Dgkh', 'Epha7', 'Plxna4',\n", " 'C1ql3', 'Sybu', 'Cplx2', 'Prox1', 'Shisa6', 'Pter'], dtype=object),\n", " 'Junb(+)': array(['Cox5b', 'Enc1', 'Lingo1', 'Olfm1', 'Lmo4', 'Wasf1', 'Nckap1',\n", " 'Cfl1', 'Tubb2a', 'Synpo', 'Ppp3ca', 'Dclk1', 'Snap25', 'Atp1a3',\n", " 'Hsp90ab1', 'Atp1b1', 'Ptms', 'Nrgn', 'Ndrg4', 'Atp1a1', 'Cox8a',\n", " 'Calm2', 'Rtn1', 'Serinc1', 'Junb', 'Ube2ql1', 'Sorcs3', 'Lmo7',\n", " 'Sptbn2', 'Egr3'], dtype=object),\n", " 'Kdm5a(+)': array(['Grin2b', 'Meg3', 'Cntnap2', 'Malat1', 'Sox5', 'Cacna1c', 'Ptprd',\n", " 'Nrxn1', 'Grid2', 'Lsamp', 'Fgf14', 'Celf2', 'Kcnd2', 'Ctnna2',\n", " 'Dlg2', 'Grm7', 'Pcdh9', 'Prickle2'], dtype=object),\n", " 'Klf12(+)': array(['Dtna', 'Lrrc7', 'Akt3', 'Hivep2', 'Rims2', 'Ube3a', 'Sgcz',\n", " 'Kat6b', 'Gphn', 'Stag1', 'Adgrl3', 'Kansl1', 'Zfp385b', 'Zfp804a',\n", " 'Sema6d', 'Enox1', 'Atxn1', 'Stxbp5l', 'Maml2', 'Slc4a4',\n", " 'Runx1t1', 'Grid2', 'Ccser1', 'Ntng1', 'Cdh2', 'Fut9', 'Dab1',\n", " 'Nlgn1', 'Acsl3', 'Msi2', 'Fgf12', 'Grm3', 'Arap2', 'Rora', 'Thrb',\n", " 'Camk1d', 'Cadm1', 'Xkr6', 'Gria4', 'Garem1', 'Mllt3', 'Ssbp2',\n", " 'Gli3', 'Chsy3', 'Peak1', 'Nfia', 'Dok6', 'Tmem164', 'Sntg1',\n", " 'Dach1', 'Mdga2', 'Baz2b', 'Arl15', 'Zfp217', 'Zeb1', 'Nrcam',\n", " 'Gabrb2', 'Cadps', 'Adgrb3', 'Nxph1', 'Erbb4', 'Trhde', 'Erc2',\n", " 'Cacna2d3', 'Kcnc2', 'Ube2e2', 'Jarid2', 'Zfpm2', 'Rgs20',\n", " 'Ppp2r3a', 'Negr1', 'Phf20l1', 'Cdh12', 'Cntnap2', 'Thsd7a',\n", " 'Brinp3', 'Nol4', 'Pcdh9', 'Cadm2', 'Robo2', 'Nfib', 'Cdh20',\n", " 'Plekhg1', 'Tenm4', 'Farp1', 'Ptchd4', 'Magi1', 'Grip1', 'Glis3',\n", " 'Dock3', 'Mapk4', 'Gpc6', 'Xkr4', 'Nrg3', 'Ptprz1', 'Auts2',\n", " 'Macrod2', 'Ctnna2', 'Ehbp1', 'Camta1', 'Grik2', 'Unc5c', 'Pde10a',\n", " 'Nrxn1', 'Rims1', 'Ctnnd2', 'Csgalnact1', 'Utrn', 'Fstl4', 'Trps1',\n", " 'Grm7', 'Pcdh17', 'Ext1', 'Zc3h7a', 'C130071C03Rik', 'Sash1',\n", " 'Lrrc4c', 'Gabrg3', 'Plcb1', 'Fgf14', 'Srrm2', 'Hs6st3', 'Magi2',\n", " 'Rgs6', 'Meg3', 'Npas3', 'Kcnd2', 'Wdr17', 'Dlgap2', 'Anln',\n", " 'Sox6', 'Sbf2', 'Fam155a', 'Syne1', 'Ptprd', 'Sdk1', 'Dennd1a',\n", " 'Nrg2', 'Magi3', 'Park2', 'Zcchc7', 'Sorbs1', 'Kirrel3', 'Esrrg',\n", " 'Olfm3', 'Ncam2', 'Rfx7', 'Robo1', 'Srgap1', 'Lhfp', 'Cdk8',\n", " 'Clasp2', 'Tmtc2', 'Arhgap26', 'Ank2', 'Prkd1', 'Kcnh7', 'Frmd4a',\n", " 'Slc35f4', 'Gpc5', 'Nrg1', 'Nebl', 'Celf2', 'Rorb', 'Mast4',\n", " 'Ttc14', 'Tjp1', 'Vps13b', 'Arhgef26', 'Nrxn3', 'Cntn5', 'Gabrb1',\n", " 'Dmd', 'Ppp2r2b', 'Zfhx3', 'Ptprt', 'Phka1', 'Pitpnc1', 'Rbms3',\n", " 'Pnisr', 'Otud7a', 'Dock4', 'Sik3', 'Ccdc85a', 'Tnik', 'Fmn2',\n", " 'Rbfox1', 'Agbl4', 'Macf1', 'Cacna1c', 'Ptprm', '4930402H24Rik',\n", " 'Sorcs1', 'Kcnn2', 'Trpm3', 'Gli2', 'Pde7b', 'Csmd1', 'Mmp16',\n", " 'Appl2', 'Mcc', 'Lrp1b', 'Carmil1', 'Rgs7', 'Fry', 'Peg3', 'Dlg2',\n", " 'Pbx1', 'Pcdh7', 'Prex2', 'C230004F18Rik', 'Mycbp2', 'Tnrc6a',\n", " 'Camk2g', 'Bcl2', 'Hivep3', 'Arid1b', 'Smyd3', 'Lrch1', 'Kctd16',\n", " 'Msra', 'Dpp6', 'Fam193a', 'Ntrk2', 'Cacna1d', 'Neat1', 'Kcnma1',\n", " 'Lars2', 'Astn2', 'Cit', 'Dcc', 'Fgfr2', 'Lsamp', 'Cd44', 'Hdac8',\n", " 'Ptprg', 'Lama2', 'Pde4d', 'Ank1', 'Xylt1', 'Tia1', 'Cdh18',\n", " 'Samd12', 'Shisa9', 'Ptprn2', 'Ntm', 'Mertk', 'Shc3', 'Kcnip4',\n", " 'Pde4b', 'F3', 'Mapk10', 'Luzp2', 'Cpeb3', 'Sfxn5', 'Adarb2',\n", " 'Nav2', 'Rmst', 'Csmd3', 'Grik1', 'Cacna1a', 'N4bp2l2', 'Dock1',\n", " 'Asic2', 'Sox5', 'Dscam', 'Lrrtm4', 'Cntnap5a', 'Malat1', 'Sgip1',\n", " 'Egfem1', 'Pcdh15'], dtype=object),\n", " 'Klf9(+)': array(['Atp2b1', 'Fbxw7', 'Gphn', 'Sept7', 'Grin2b', 'Cnksr2', 'Rora',\n", " 'Nlgn1', 'Stxbp5l', 'Magi2', 'Camk1d', 'Syt1', 'Mef2c', 'Pcdh9',\n", " 'Dlgap1', 'Lsamp', 'Cadm2', 'Ppp3ca', 'Gnao1', 'Nrxn1', 'Prkce',\n", " 'Plcb1', 'Dclk1', 'Tcf4', 'Jarid2', 'Phactr1', 'Pitpnc1', 'Mdga2',\n", " 'Adgrb3', 'Enc1', 'Peak1', 'Syne1', 'Kcnq3', 'Tmtc2', 'Cyfip2',\n", " 'Cd44', 'Trpm3', 'Gria2', 'Zc3h7a', 'Cdk8', 'Qk', 'Calm1', 'Celf2',\n", " 'Slc24a2', 'Ywhah', 'Macf1', 'Chn1', 'Klf9', 'Cmss1', 'Malat1'],\n", " dtype=object),\n", " 'Lef1(+)': array(['Vangl1', 'Shox2', 'Edn3', 'Lef1', 'Adgrl4', 'Sh3d19', 'Prkcd',\n", " 'Mctp2', 'Vav3', 'Lhcgr', 'Synpo2', 'Olfm3', 'Ptpn3', 'Samd5',\n", " 'Rbms3', 'Atp10a', 'Lrrc7'], dtype=object),\n", " 'Lmx1b(+)': array(['Lmx1b', 'Foxa1', 'Sv2c', 'Crabp2', 'Drd2', 'Klhl1', 'Ddc', 'En1',\n", " 'Fmod', 'Ret', 'Th', 'Chrna6', 'Slc6a3', 'Chrna4'], dtype=object),\n", " 'Maf(+)': array(['Gad1', 'Igf2', 'Alx4', 'Erbb4', 'Rbms3', 'Gad2', 'Dlx1as',\n", " 'Atp1a2', 'Maf', 'Camk1d', 'Slc6a1', 'Fmod', 'Mrc1', 'Dlx6os1',\n", " 'Sst', 'Nxph1', 'Sema3b', 'D130009I18Rik', 'Slc13a4', 'Csf1r'],\n", " dtype=object),\n", " 'Mbnl2(+)': array(['Atp2b1', 'Cdk17', 'Lrrc7', 'Pafah1b1', 'Atf2', 'Akt3', 'Cnksr2',\n", " 'Galnt13', 'Hivep2', 'Rfx3', 'Fbxw7', 'Rims2', 'Ube3a', 'Lingo2',\n", " 'Sgcz', 'Tanc2', 'Gphn', 'Sept7', 'Adgrl3', 'Ttc3', 'Enox1',\n", " 'Syt1', 'Atxn1', 'Stxbp5l', 'Pja2', 'Ccser1', 'Dlgap1', 'Basp1',\n", " 'Dpp10', 'Cacna2d1', 'Dab1', 'Nlgn1', 'Numb', 'Car10', 'Fgf12',\n", " 'Cdkl5', 'Kif1b', 'Thrb', 'R3hdm1', 'Nbea', 'Ralyl', 'Anks1b',\n", " 'Sptan1', 'Foxp1', 'Wasf1', 'Ppp1r12a', 'Xkr6', 'Ncor1', 'Lyst',\n", " 'Frmpd4', 'Sipa1l1', 'Gria2', 'App', 'Chsy3', 'Hecw2', 'Dok6',\n", " 'Sntg1', 'Lrfn5', 'Ppp1r9a', 'Zeb2', 'Mdga2', 'Calm2', 'Nckap1',\n", " 'Nrcam', 'Gabrb2', 'Arpp21', 'Oxr1', 'Epha6', 'Ppp3ca', 'Tmeff2',\n", " 'Unc80', 'Cadps', 'Apba2', 'Adgrb3', '5730522E02Rik', 'Capza2',\n", " 'Rock2', 'Flrt2', 'Trank1', 'Erc2', 'Rab6a', 'Enc1', 'Hecw1',\n", " 'Cacna2d3', 'Frmd5', 'Homer1', 'Ube2e2', 'Nkain2', 'Jarid2',\n", " 'Herc1', 'Prickle1', 'Grm5', 'Kcnq3', 'Man1a2', 'Plcl1', 'Negr1',\n", " 'Phf20l1', 'Cdh12', 'Cntnap2', 'Cntn1', 'Snap25', 'Ttll7', 'Strn',\n", " 'Pcdh9', 'Cadm2', 'Map1b', 'Lmo4', 'Gls', 'Mef2c', 'Map7d2',\n", " 'Mlf2', 'Tenm4', 'Farp1', 'Kcnj3', 'Rasal2', 'Dock3', 'Ssh2',\n", " 'Gpc6', 'Xkr4', 'Sub1', 'March1', 'Nrg3', 'Mapt', 'Auts2',\n", " 'Macrod2', 'Ctnna2', 'Pak7', 'Ppfia2', 'Map9', 'Akap11', 'Atp6v1a',\n", " 'Camta1', 'Amph', 'Grik2', 'Nrxn1', 'Osbpl1a', 'Rims1', 'Ctnnd2',\n", " 'Eml5', 'Ywhae', 'Dclk1', 'Kcnq5', 'Ppp3r1', 'Agtpbp1', 'Grm7',\n", " 'Ext1', 'Zc3h7a', 'Atp8a1', 'Lrrc4c', 'Zbtb18', 'Trim9', 'Plcb1',\n", " 'Fgf14', 'Ywhaz', 'Hs6st3', 'Magi2', 'Meg3', 'Brinp1', 'Pcsk2',\n", " 'Edil3', 'Caln1', 'Kcnd2', 'Tnrc6c', 'Csmd2', 'Dlgap2', 'Fam19a1',\n", " 'Grin2b', 'Gnaq', 'Scn8a', 'Fam155a', 'Syne1', 'Unc79', 'Mkl2',\n", " 'Ptprd', 'Itpr1', 'Phactr1', 'Cttnbp2', 'Park2', 'Zcchc7',\n", " 'Kirrel3', 'Kcna1', 'Cacna1e', 'Ncam2', 'Ptk2', 'Cdk8', 'Grin2a',\n", " 'Clasp2', 'Tmtc2', 'Arhgap26', 'Ank2', 'C2cd5', 'Kcnh7', 'Serbp1',\n", " 'Pgm2l1', 'Rtn1', 'Frmd4a', 'Cntn4', 'Calm1', 'Rtf1', 'Nrg1',\n", " 'Actr2', 'Pclo', 'Celf2', 'Dgkh', 'Mbnl2', 'Hsp90ab1',\n", " '2010300C02Rik', 'Rtn4', 'Chrm3', 'Slc24a2', 'Mast4', 'Hs3st4',\n", " 'Scai', 'Ncald', 'Ttc14', 'Dst', 'Cacnb4', 'Nrxn3', 'Cntn5', 'Dmd',\n", " 'Mapk1', 'Ppp2r2b', 'Ywhah', 'Tcf4', 'Map7', 'Plekha5', 'Nptn',\n", " 'Dscaml1', 'Palm2', 'Micu3', 'Pnisr', 'Acap2', 'Sytl2', 'Otud7a',\n", " 'Dock4', 'Sh3gl2'], dtype=object),\n", " 'Mef2d(+)': array(['Snap25', 'Atp1a3', 'Hsp90ab1', 'Ppp3ca', 'Atp1b1', 'Ptms', 'Ttc3',\n", " 'Syt11', 'Dclk1', 'Map1b'], dtype=object),\n", " 'Msx1(+)': array(['Osr1', 'Wnt5a', 'Ahnak', 'Msx1', 'Atp1a2', 'Col1a1', 'Wnt6',\n", " 'Ptn', 'Cnn2', 'Serpinf1', 'Dab2', 'Bmp4', 'Id1', 'Fbln1', 'Mpzl2',\n", " 'Tnfrsf1a', 'Col1a2', 'Stab1', 'Pear1', 'Maf'], dtype=object),\n", " 'Mtf1(+)': array(['Stmn2', 'Gnas', 'Wasf1', 'Tceal3', 'Pafah1b1', 'Bex3', 'Vamp2',\n", " 'Snca', 'Lmo4', 'Rab6a', 'Calm2', 'Hspa8', 'Anks1b', 'Basp1',\n", " 'Gria2', 'Ppp3ca', 'Ppp3r1', 'Sub1', 'Morf4l2', 'Ndrg3', 'Ywhae',\n", " 'Nap1l1', 'Cdc42', 'Camkv', 'Atp6v1a', 'Ywhag', 'App', 'Capza2',\n", " 'Map1b', 'Rtn3', 'Cnih2', 'Prkar1b', 'Maged1', 'Nckap1', 'Arf3',\n", " 'Snap25', 'Stmn4', 'Hsp90ab1', 'Syp', 'Atxn10', 'Ppp2ca', 'Stmn1',\n", " 'Gap43', 'Ssh2', 'Caly', 'Ptms', 'Rimklb', 'Mllt11', 'Crmp1',\n", " 'Gpm6a', 'Slc25a4', 'Hpca', 'Lingo1', 'Bex2', 'Ywhaz', 'Reps2',\n", " 'Ywhah', 'Slc17a7', 'Tceal5', 'Pfn2', 'Syn2', 'Thra', 'Ncdn',\n", " 'Dnm1', 'Tspan13', 'Snrpn', 'Prkcg', 'Gria3', 'Enc1', 'Pgm2l1',\n", " 'Abr', 'Tmsb4x', 'Gdi1', 'Hpcal4', 'Serp2', 'Chn1', 'Eif1',\n", " 'Rpl17', 'Rpl29', 'Nsf', 'Itm2c', 'Chst1', 'Camk2n1', 'Mtch1',\n", " 'Rtn1', 'Arpc2', 'Atp6v1b2', 'Nptxr', 'Cox6c', 'Pkm', 'Cpne6',\n", " 'Atp5a1', 'Calm1', 'Ddn', 'Aplp1', 'Olfm1', 'Prnp', 'Ube2b',\n", " 'Dnaja1', 'Rpl37', 'Stmn3', 'Pitpna', 'Thy1', 'Eif5a', 'Syt11',\n", " 'Dynll1', 'Ckmt1', 'Nrgn', 'Tubb2a', 'Tubb5', 'Rps14', 'Atpif1',\n", " 'Cpne7', 'Atp6ap2', 'Ap2s1', 'Uchl1', 'Sult4a1', 'Ndufb6', 'Mtf1',\n", " 'Tspan3', 'Atp9a', 'Cox6b1', 'Tmsb10', 'Mapk1', 'Tpi1', 'Psmb1',\n", " 'Actr2', 'Selenow', 'Atp5g3', 'Ubb', 'Serinc1', 'Pde1a', 'Rpl13a',\n", " 'Eif4a2', 'Fbxl16', 'Gabarapl1', 'Nsg2', '4930481A15Rik', 'Ywhab',\n", " 'Frrs1l', 'Rtn4', 'Calm3', 'Chgb', 'Ldha', 'Atp5d', 'Sncb', 'Arf1',\n", " 'Rpl14', 'Cox17', 'Sdhb', 'Atp5g1', 'Gapdh', 'Gnb1', 'Rplp1',\n", " 'Gtf2h5', 'Tuba1b', 'Ap1s1', 'Rpl22l1', 'Wdr89', 'Tpt1', 'Cck',\n", " 'Mdh2', 'Atp1b1', 'Atp6v1g2', 'Celf4', 'Nme7', 'Gm21949', 'Apbb1',\n", " 'Rab3a', 'Rps17', 'Dctn3', 'Tomm7', 'Usmg5', 'Ndufa4', 'Napa',\n", " 'Atp5j', 'Brk1', 'Fam162a', 'Mt3', 'Nov', 'Klc1', 'Cox5b', 'Dctn2',\n", " 'Rps10', 'Rpl5', 'Rpl21', 'Pcsk1n', 'Actb', 'Crym', 'Mal2',\n", " 'Cox4i1', 'Atp5j2', 'Clta', 'Rrp1', 'Zwint', 'Ly6h', 'Snhg11',\n", " 'Gpi1', 'Cox5a', 'Myl6', 'Ndufv3', 'Hint1', 'Rpl11', 'Rprml',\n", " 'Vdac1', 'Hdac11', 'Mif', 'Dpysl2', 'Dynlrb1', 'Zbtb18',\n", " '2410015M20Rik', 'Rpl36', 'Ptk2b', 'Vps29', 'Ppia', 'Ndrg4',\n", " 'Tuba4a', 'Ndufb7', 'Atp6v1d', 'Sec11c', 'Rogdi', 'Hsp90aa1'],\n", " dtype=object),\n", " 'Nfatc4(+)': array(['Zic2', 'Ahnak', 'Bgn', 'Atp1a2', 'Col1a1', 'Crabp2', 'Bmp5',\n", " 'Fmod', 'Nfatc4', 'Bmp7', 'Slc13a4', 'Lama1', 'Perp', 'Vsx1',\n", " 'Hmgcs2', 'Rbp1', 'Ptgds', 'Slc47a1', 'Gjb2', 'Foxc2', 'Txnip',\n", " 'Vwf', 'Slc6a12', 'Fxyd5', 'Olfml2a', 'Slc16a9', 'Foxc1',\n", " 'Adamtsl3', 'Mpzl2', 'Gfap', 'Wfdc1', 'Wnk4', 'Asgr1', 'Wnt5a',\n", " 'Zic1', 'Pbxip1', 'Fgfbp1', 'Mgp', 'Lum', 'Apod', 'Krt80',\n", " 'C230024C17Rik', 'Tnfrsf1a', '1500015O10Rik', 'Anxa1', 'Islr',\n", " 'Fbln1', 'Myoc', 'Igf2', 'Fn1', 'Slc26a2', 'Slc6a20a', 'Col1a2',\n", " 'Colec12', 'Slc6a13', 'Lbp', 'Slc22a8'], dtype=object),\n", " 'Nfe2l2(+)': array(['Igf2', 'Plp1', 'Qk', 'Nfe2l2', 'Cldn11', 'Glul', 'Gfap', 'Ptgds',\n", " 'Mt1'], dtype=object),\n", " 'Nfib(+)': array(['Atp2b1', 'Zcchc11', 'Ube3a', 'Nr3c2', 'Rfx3', 'Cdk17', 'Dtna',\n", " 'Lrrc7', 'Tanc2', 'Akt3', 'Stag1', 'Cnksr2', 'Ccnd2', 'Adgrl3',\n", " 'Atxn1', 'Kansl1', 'Stxbp5l', 'Hivep2', 'Smarca2', 'Syt1', 'Maml2',\n", " 'Nbea', 'Mctp1', 'Epha6', 'Nlgn1', 'Wasf1', 'Dlgap1', 'Lingo2',\n", " 'Apba2', 'Basp1', 'Dab1', 'R3hdm1', 'Cacna2d1', 'Frmpd4', 'Gli3',\n", " 'Zfpm2', 'Ncor1', 'Sema5a', 'Cadm1', 'Mllt3', 'Ppp1r9a', 'Meg3',\n", " 'Large1', 'Msi2', 'Snca', 'Anks1b', 'Calm2', 'Slc4a4', 'Sipa1l1',\n", " 'Ywhaz', 'Prkg1', 'Gucy1a2', 'Arhgap21', 'Sub1', 'Ptprz1', 'Rora',\n", " 'Adgrb3', 'Pip5k1b', 'Csgalnact1', 'Ncoa1', 'Gria2', 'Diaph2',\n", " 'Npas2', 'Nfia', 'Garem1', '5730522E02Rik', 'Gabra5', 'Psip1',\n", " 'Unc80', 'Lmo4', 'Cdc42se2', 'Gabra2', 'Mdga2', 'Atrnl1', 'Glis3',\n", " 'Lyst', 'Pdcd4', 'Ncam1', 'Caln1', 'Dock3', 'Slc7a14', 'Ywhae',\n", " 'Erc2', 'Mapk4', 'Nfib', 'Matr3', 'Nckap1', 'Capza2', 'Eef1a1',\n", " 'Ssbp2', 'Pcdh9', 'Camkv', 'Dlgap2', 'Ctnna2', 'Rbfox1', 'Ppp3r1',\n", " 'Arpp21', 'Nrcam', 'Phf20l1', 'Ppp3ca', 'Nkain2', 'Zeb1', 'Srrm2',\n", " 'C130071C03Rik', 'Npas3', 'Nucks1', 'Dlg3', 'Plcb1', 'Atp6v1a',\n", " 'Mef2d', 'Magi2', 'Robo2', 'Dclk1', 'Auts2', 'Zbtb18', 'Ptprd',\n", " 'Xkr4', 'Arhgef28', 'Farp1', 'Bcl11b', 'Dapk1', 'Fam19a1',\n", " 'Zcchc7', 'Ppfia2', 'Zfp706', 'Nrxn1', 'Fgf14', 'Cplx2', 'Hs3st4',\n", " 'Rasal2', 'Brinp1', 'H3f3a', 'Anp32a', 'Gls', 'Pcsk5', 'Nrg3',\n", " 'Gnao1', 'Ube2e2', 'Fam155a', 'Fam49a', 'Cttnbp2', 'Rock2', 'Ptk2',\n", " 'Prox1', 'Trps1', 'Pgm2l1', 'Dennd1a', 'Rgl1', 'Setbp1', 'Frmd4a',\n", " 'Trim9', 'Negr1', 'Serbp1', 'Arf1', 'Ptpra', 'Sptbn2', 'Kirrel3',\n", " 'Ncam2', 'Abi1', 'Ctnnd2', 'Prkag2', 'Rgs20', 'Gm20754', 'Csmd1',\n", " 'Csnk1a1', 'Grm5', 'Arf3', 'Cadm2', 'Mkl2', 'Nkain3', 'Bex2',\n", " 'Tnrc6c', 'Mmp16', 'Celf2', 'Enc1', 'Kcnma1', 'Epha7', 'C1ql3',\n", " 'Wdr17', 'Plxna4', 'Grm7', 'Camk2b', 'Gnaq', 'Pde1a', 'Cnrip1',\n", " 'Cap2', 'Otud7a', 'Gabrb1', 'Iqgap2', 'Tsc22d1', 'Syt17', 'Sorbs1',\n", " 'Cacna1d', 'Eif5a', 'Foxo1', 'Rprm', 'Dscaml1', 'Tspan13', 'Lmo7',\n", " 'Nrp1', 'Hmgn3', 'Pitpnc1', 'Macrod2', 'Pkig', 'Cacng8', 'Acap2',\n", " 'Hpca', 'Cnih3', 'Grik2', 'Fam135b', 'Fars2', 'Dgkg', 'Thra',\n", " 'Csmd2', 'Slc44a5', 'Macf1', 'Actr3', 'Celf5', 'Grin2b', 'Foxg1',\n", " 'Nebl', 'Ywhab', 'Pnisr', 'Kcnn2', 'Ryr2', 'Caly', 'Gpm6a',\n", " 'Lsamp', 'Rtn1', 'Pter', 'Neat1', 'Cacna1c', 'Cnih2', 'Map2k1',\n", " 'Hsp90ab1', 'Park2', 'Neurod2', 'Prkd1', 'Celf3', 'Chn1', 'Fmn2',\n", " 'Dock4', 'Hmgb1', 'Tcf4', 'Syt7', 'Myo5b', 'Adgrb2', 'Kcnd2',\n", " 'Kcnh7', 'Tnik', 'Cers6', 'Arhgap26', 'Ptprg', 'Syne1', 'Dynll1',\n", " 'Ank2', 'Ncald', 'Plxna2', 'Asic2', 'Lrp1b', 'Tpm1', 'Nfix',\n", " 'Gabrb3', 'Calm1', 'Cacna1e', 'Sgip1', 'Trpm3', 'Egfem1', 'Ptms',\n", " 'Chst1', 'Gpc5', 'Phactr1', '2010300C02Rik', 'Syn2', 'Dpyd',\n", " 'Mertk', 'Mapk1', 'Serp2', 'Grin2a', 'Ptprt', 'Plekha5', 'Chd3',\n", " 'Shisa6', 'Dip2c', 'Arpc2', 'Klhl2', 'Plekhg5', 'Rbfox3', 'Astn2',\n", " 'Nsf', 'Clstn2', 'Kctd16', 'Ntrk3', 'Tle4', 'Nptx1', 'Appl2',\n", " 'Med26', 'Actb', 'Miat', 'Slc17a7', 'Hivep3', 'Agbl4', 'Ttll6',\n", " 'Dgkb', 'Nell2', 'Acvr2a', 'Tjp1', 'Mmp17', 'Ak5', 'Psma3',\n", " 'Ogfrl1', 'Ccdc85a', 'Stim2', 'Tceal5', 'Shisa9', 'Dmd', 'Nedd4l',\n", " 'Dlg2', 'Tpm3', 'Ahcyl2', 'Fbxl16', 'Fgd4', 'Zbtb16', 'Npy2r',\n", " 'Dsp', 'Meis2', 'Pbx1', 'A830018L16Rik', 'Rapgef4', 'Ptprj',\n", " 'Cyp7b1', 'Hrk', 'Mink1', 'Neurod1', 'Rasgef1a', 'Syngap1',\n", " 'Ppp1r1a', 'Slit3', 'Gria3', 'Rgs7bp', 'Slc1a2', 'Synpr', 'Sybu',\n", " 'Hpcal4', 'Itm2c', 'Fam171b', 'Prickle2', 'Add2', 'Pde4d', 'Cpne6',\n", " 'Ptk2b', 'Sox5', 'Myt1l', 'Prkce', 'Lama2', 'Mycbp2', 'Tubb2b',\n", " 'Id4', 'Prex2', 'Msra', 'Plppr4', 'Dgkh', 'Kcnip2', 'Tusc3', 'Fry',\n", " 'Plppr2', 'Neto1', 'Camk2a', 'Mmd', 'Nt5dc3', 'Me3', 'Galnt18',\n", " 'Adcy1', 'Ryr3', 'Tmem132b', 'Xist', 'Kcnip4', 'Csmd3', 'Celf4',\n", " 'Btbd9', 'Hnrnpa3', 'Nos1ap', 'Xylt1', 'Dbn1', 'Tspan18', 'Tmsb4x'],\n", " dtype=object),\n", " 'Nfyb(+)': array(['Slc8a2', 'Lypd1', 'Rbfox3', 'Egr3', 'Adgrb2', 'Lin7c', 'Mmp17',\n", " 'Crmp1', 'Pop5', 'Gpr39', 'Plppr2', 'Abr', 'C1qtnf4', 'Syt7',\n", " 'Atp2b4', 'Mef2d', 'Prkar1a'], dtype=object),\n", " 'Nkx6-1(+)': array(['Igf2', 'Foxd2', 'C1ql4', 'Apod', 'S100a9', 'Tagln'], dtype=object),\n", " 'Nkx6-2(+)': array(['Ddr1', 'Mobp', 'Nmral1', 'Gltp', 'Vmp1', 'Mbp', 'Hcn2',\n", " 'Arhgap23', 'Sept4', 'Cdc42ep2', 'Myrf', 'Jam3', 'Csrp1', 'Tubb4a',\n", " 'Ugt8a', 'Gpm6b', 'Rnf13', 'Gpr37', 'Inpp5a', 'Myo6', 'Pls1',\n", " 'Dock10', 'Gjc3', 'Qdpr', 'Efnb3', 'Grb14', 'Rap1a', 'Rpl37a',\n", " 'Pde4b', 'Car2', 'Pdlim2', 'Dbi', 'Pip4k2a', 'Phldb1', 'Cdk8',\n", " 'Otud7b', 'Serpinb1a', 'Atp1b3', 'Slc38a2', 'Mapk8ip1', 'Ppp1r14a',\n", " 'Cntn2', 'Glul', 'Rtkn', 'Gatm', 'Fa2h', 'Evi2a', 'Tmbim1', 'Ermn',\n", " 'S100a16', 'Stmn4', 'Cd81', 'Nkx6-2', 'Tnni1', 'Gsn', 'Unc5b',\n", " 'Tmem63a', 'Mag', 'Ppp1r16b', 'Traf5', 'Plekhb1', 'Tmem88b',\n", " 'Rhog', 'Bin1', 'Cers2', 'Ndrg1', 'S100b', 'Apod', 'Smad7', 'Mcam',\n", " 'Ninj2', 'Lgi3', 'Lpar1', 'Efhd1', 'Ptma', 'Mal', 'Scd2', 'Cmtm5',\n", " 'Foxn3', 'Josd2', 'Qk', 'Plekha1', 'Tsc22d4', 'Sept7', 'Slc44a1',\n", " 'Lamp1', 'Cldn11', 'Clic4', 'Plp1', 'Pllp', 'Kcnj10', 'Gjb1',\n", " 'Sgk1', 'Slc12a2', 'Il33', 'Gjc2', 'Tfeb', 'Slc6a9', 'Cd82',\n", " 'Adssl1', 'Sema4d', 'Plekhg3', 'Gng11', 'Micall1', 'Gstm7',\n", " 'Ypel2', 'Scd1', 'Cdc42ep1', 'Gm15417', 'Erbb3', 'Tmem229a',\n", " 'Plxdc2', 'Klk6', 'Kazn', 'Map7d1', 'Wnk1', 'S100a1', 'Phgdh',\n", " 'Agpat4', 'Tmcc3', 'Tmem123', 'Phlda3', 'Mog', 'Degs1', 'S100a13',\n", " 'Dock5', 'Arsg', 'Padi2', 'Dixdc1', 'Galnt6', 'Litaf', 'Cdr2l',\n", " 'Opalin', 'Aph1a', 'S1pr5', 'Lap3', 'Trf', 'Ddit4', 'Olfml1',\n", " 'Trim59', 'Prr18', 'Cnp', 'Sec14l5', 'Npc2', 'Gprc5b', 'Cryab',\n", " 'Gal3st1', '9630013A20Rik', 'Tspan2', 'Rdx', 'Cdh19', 'Cd9',\n", " 'Klf13', '5031439G07Rik', 'Daam1', 'Pde8a', 'Arrdc3', 'Hapln2',\n", " 'Rhou', 'Mtmr2', 'Zdhhc9', 'Cd63', 'Serinc5', 'Pla2g16', 'Slain1',\n", " 'Bcas1', 'Rnf7', 'Ppp2r3a', 'Sh3gl3', 'Itgad', 'Dbndd2', 'Olig2',\n", " 'Nudt4', '2310022B05Rik', 'Kif13a', 'Cyp2j12', 'Epb41l3',\n", " 'Slc48a1', 'Hhip', 'Pacs2', 'Fth1', 'Olig1', 'Endod1', 'Ddc',\n", " 'Elovl1', 'Sox10', 'Nfasc', 'Tmeff2', 'Kcna1', 'St18', 'Edil3',\n", " 'Phactr3', 'Elmo1', 'Gphn', 'Itpk1', 'Ano4', 'D7Ertd443e',\n", " 'Plxnb3', 'Ptgds', 'Fez1', 'Secisbp2l', 'Kndc1', 'Hipk2', 'Creb5',\n", " 'Kif5a', 'Arhgef10', 'Map7', 'Slc6a3', 'Reep3', 'Sparc', 'Sec11c',\n", " 'Hepacam', 'Chd7', 'BC049715', 'Rcan2', 'Zfp536', 'Enpp2', 'Daam2',\n", " 'Selenop', 'Plekhh1', 'Wscd1', 'Cd44', 'Plcl1', 'Frmd8', 'Gfap',\n", " 'Carhsp1', 'Rab31', 'Arpc1b', 'Tmem125', 'Aldh1a1', 'Psat1',\n", " 'Sez6l2', 'Ccp110', 'Clasp2'], dtype=object),\n", " 'Nr2f1(+)': array(['Meg3', 'Cdk17', 'Atp2b1', 'Stmn2', 'Cnksr2', 'Syt1', 'Ttc3',\n", " 'Fbxw7', 'Tceal3', 'Pja2', 'Bex3', 'Nrn1', 'Vamp2', 'Snca',\n", " 'R3hdm1', 'Tceal9', 'Auts2', 'Slc39a10', 'Lmo4', 'Erc2', 'Rab6a',\n", " 'Calm2', 'Hspa8', 'Cadm1', 'Basp1', 'Prmt8', 'Abi2', 'Gria2',\n", " 'Gabbr1', 'Cadm3', 'Ppp3ca', 'Sipa1l1', 'Ppp3r1', 'Sub1', 'Scn8a',\n", " 'Ptprs', 'Ndrg3', 'Brinp1', 'Ywhae', 'Serpini1', 'Hivep2',\n", " 'Nap1l1', 'Mef2c', 'Cdc42', 'Tspan7', 'Camkv', 'Chrm1', 'Nrxn1',\n", " 'Atp6v1a', 'Gabra4', 'Ywhag', 'Cd47', 'Prkacb', 'Dlgap1', 'App',\n", " 'Cadm2', 'Nrxn3', 'Vgf', 'Egr3', 'Unc5d', 'Celf5', 'Anp32a',\n", " 'Car10', 'Prkar1b', 'Slc22a17', 'Nckap1', 'Ppp1r9a', 'Tceal6',\n", " 'Nlgn3', 'Spred1', 'Arf3', 'Adgrl1', 'Nrcam', 'Cplx2', 'Nrxn2',\n", " 'Gnao1', 'Grm5', 'Tmem191c', 'Myh7', 'Cacna2d1', 'Snap25', 'Stmn4',\n", " 'Slitrk1', 'Grin2a', 'Nptn', 'Dlg3', 'Hsp90ab1', 'Grin2b', 'Tcf4',\n", " 'Cdk5r2', 'Syp', 'Adgrb1', 'Homer1', 'Sptan1', 'Sqstm1', 'Gpm6b',\n", " 'Mir124a-1hg', 'Stmn1', 'Phactr1', 'Ptprd', 'Pcsk2', 'Fzd3',\n", " 'Camk2b', 'Caly', 'Ptms', 'Crmp1', 'Syngap1', 'Gpm6a', 'Hpca',\n", " 'Rab33a', 'Ptn', 'Necab1', 'Lingo1', 'Bex2', 'Osbpl1a', 'Ttyh1',\n", " 'Ywhaz', 'Etv5', 'Ywhah', 'Slc17a7', 'Tceal5', 'Serbp1', 'Cabp1',\n", " 'Pter', 'Tsc22d1', 'Cux2', 'Syn2', 'Sptbn2', 'Thra', 'Napb',\n", " 'Dnm1', 'Tmem50a', 'Arpp21', 'Tpm3', 'Gria3', 'Enc1', 'Stxbp1',\n", " 'Kcnv1', 'Pgm2l1', 'Abr', 'Fam49b', 'Syt7', 'Lingo2', 'Map2k1',\n", " 'Farp1', 'Hpcal4', 'Serp2', 'Chn1', 'Snn', 'AI593442', 'Celf1',\n", " 'Ttc9b', 'Eif1', 'Dmtn', 'Madd', 'Zfp706', 'Eef1a2', 'Negr1',\n", " 'Gng13', 'Itm2c', 'Cacnb3', 'Camk2a', 'Kcnb1', 'Chst1', 'Camk2n1',\n", " 'Grik5', 'Svop', 'Rtn1', 'Akap8l', 'Arpc2', 'Atp6v1b2', 'Mtpn',\n", " 'Camta2', 'Fscn1', 'Tenm2', 'Nptxr', 'Syn1', 'Phf24', 'Slc12a5',\n", " 'Camkk2', 'Pkm', 'Nr2f1', 'Tusc3', 'Epha4', 'Calm1', 'Ddn',\n", " 'Aplp1', 'Shank2', 'Fxyd7', 'Olfm1', 'Ngef', 'Sorbs2',\n", " 'A830082K12Rik', 'Prnp', 'Tenm4', 'Kcnip4', 'Ncald', 'Marc2',\n", " 'Thy1', 'Rap2b', 'Shank1', 'Slc1a2', 'Eif5a', 'Syt11', 'C1qtnf4',\n", " 'Dynll1', 'Ntm', 'Dlk2', 'Ppp1r1a', 'Synpo', 'Syt16', 'Marcks',\n", " 'Nrgn', 'Rasgrp1', 'Tspan5', 'Tubb2a', 'Tubb5', 'Camk4', 'Atpif1',\n", " 'Coro1a', 'Vsnl1', 'Ypel3', 'Atp2b2', 'Atp6ap2', 'Dbp',\n", " '2010300C02Rik', 'Uchl1', 'Sult4a1', 'Cyfip2', 'Nek6', 'Prkcb',\n", " 'Ids', 'Dclk1', 'Plxnd1', 'Atp9a', 'Mapk1', 'Tpi1', 'Miat',\n", " 'Ptprn', 'Nsg1', 'Gas7', 'Ubb', 'Micu3', 'Serinc1', 'Mef2d',\n", " 'Phyhip', 'Calb1', 'Ext1', 'Golga7b', 'Fbxl16', 'Sptbn1', 'Gabbr2',\n", " 'Gabarapl1', 'Nsg2', 'Ywhab', 'Frrs1l', 'Clstn1', 'Prex1', 'Cfl1',\n", " '6330403K07Rik', 'Faim2', 'Rtn4', 'Icam5', 'Stx1a', 'Fam212b',\n", " 'Fxyd6', 'Calr', 'Cspg5', 'Arpp19', 'Grin1', 'Dusp14', 'Scn2a',\n", " 'Vdac1', 'Bsn', 'Slc1a3', 'Strn4', 'Klc1', 'Pcsk1n', 'Mapk8ip3',\n", " 'Rbfox3', 'Tpm1', 'Tuba1a', 'Cbx6', 'Ppia', 'Tbc1d9', 'Calm3',\n", " 'Pi4ka', 'Kctd17', 'Kifap3', 'Apbb1', 'Nme1', 'Clu', 'Car4',\n", " 'Ap3m2'], dtype=object),\n", " 'Nr2f2(+)': array(['Cnr1', 'Bex3', 'Stmn2', 'Nr2f2', 'Basp1', 'Camk2d', 'Snca',\n", " 'Gnas', 'Bex1', 'Ywhae', 'Camkv', 'Tceal9', 'Zcchc12', 'Pgrmc1',\n", " 'Bex2', 'Eif5a', 'Rtn1', 'Cnih2', 'Dynll1', 'Penk', 'Syn2',\n", " 'Hpcal1', 'Tceal5', 'Tubb2a', 'Pnck', 'Nlgn3', 'Calb1', 'Gjb2',\n", " 'Mtch1', 'Cpne7', 'Rpl21', 'Calb2', 'Itm2c', 'Col1a1', 'Ndn',\n", " 'Nov', 'Ly6h', 'Tuba1b', 'Fxyd6', 'Cpne6', 'Stum', 'Pcolce',\n", " 'Timp2', 'Gap43', 'Pea15a', 'Nptxr', 'Uchl1', 'Pnmal2', 'Nsg2',\n", " 'Fmod', '6330403K07Rik', 'Icam5', 'Lypd1', 'Rpl22l1', 'Igf2',\n", " 'Pcdh19'], dtype=object),\n", " 'Nr3c1(+)': array(['Nr3c1', 'Atp2b1', 'R3hdm1', 'Sept7', 'Kcnd2', 'Ldlrad4', 'Homer1',\n", " 'Mef2c', 'Kctd1', 'Pcdh9', 'Nrxn1', 'Plcb1', 'Tcf4', 'Ppp2r2b',\n", " 'Phactr1', 'Ptprd', 'Celf2', 'Osbpl1a', 'Kcnip4', 'Pde1a', 'Ntm',\n", " 'Pcsk2', 'Dlg2', 'Camk4', 'Arhgap26', 'Clstn1', 'Nrgn', 'Sv2b',\n", " 'Rgs6', 'Kctd16', 'Sub1'], dtype=object),\n", " 'Ovol2(+)': array(['R3hdm1', 'Snap25', 'Syt1', 'Mef2c', 'Car10', 'Pcsk2', 'Camk2n1',\n", " 'Nrg1', 'Phactr1', 'Vsnl1', 'Lmo4', 'Col8a1', 'Dclk1', 'Slc17a7',\n", " 'Arpp21', 'Nrgn', 'Ovol2', 'Kcnh7', 'Egr1', 'Kalrn'], dtype=object),\n", " 'Pbx1(+)': array(['Atp2b1', 'Dtna', 'Lrrc7', 'Akt3', 'Cnksr2', 'Hivep2', 'Rims2',\n", " 'Ube3a', 'Sgcz', 'Tanc2', 'Gphn', 'Stag1', 'Adgrl3', 'Kansl1',\n", " 'Ptpn4', 'Ttc3', 'Sema6d', 'Syt1', 'Stxbp5l', 'Slc4a4', 'Grid2',\n", " 'Ccser1', 'Mctp1', 'Cdh2', 'Dlgap1', 'Basp1', 'Foxp2', 'Fut9',\n", " 'Dpp10', 'Dab1', 'Nlgn1', 'Acsl3', 'Msi2', 'Fgf12', 'Grm3', 'Pam',\n", " 'Rora', 'Thrb', 'Camk1d', 'R3hdm1', 'Nbea', 'Ralyl', 'Anks1b',\n", " 'Foxp1', 'Cadm1', 'Xkr6', 'Frmpd4', 'Prr16', 'Kcnt2', 'Garem1',\n", " 'Gria2', 'Ssbp2', 'Gli3', 'Chsy3', 'Peak1', 'Nfia', 'Hecw2',\n", " 'Dok6', 'Sntg1', 'Mdga2', 'Zfp217', 'Zeb1', 'Cdh11', 'Nrcam',\n", " 'Gabrb2', 'Arpp21', 'Oxr1', 'Unc80', 'Cadps', 'Apba2', 'Adgrb3',\n", " 'Npas2', '5730522E02Rik', 'Dnm3', 'Erbb4', 'Lrba', 'Erc2',\n", " 'Cacna2d3', 'Homer1', 'Nkain2', 'Jarid2', 'Zfpm2', 'Herc1',\n", " 'Rgs20', 'Prickle1', 'Grm5', 'Kcnq3', 'Large1', 'Negr1', 'Cntnap2',\n", " 'Cntn1', 'Brinp3', 'Syt14', 'Nol4', 'Pcdh9', 'Cadm2', 'Map1b',\n", " 'Lmo4', 'Gls', 'Robo2', 'Nfib', 'Cdh20', 'Atrnl1', 'Tenm4',\n", " 'Farp1', 'Rasal2', 'Dock3', 'Mapk4', 'Gpc6', 'Xkr4', 'Tspan7',\n", " 'March1', 'Nrg3', 'Thsd7b', 'Ptprz1', 'Auts2', 'Macrod2', 'Ctnna2',\n", " 'Gnao1', 'Ehbp1', 'Camta1', 'Asap2', 'Pde10a', 'Nrxn1', 'Rims1',\n", " 'Ctnnd2', 'Csgalnact1', 'Nckap5', 'Rtn3', 'Dclk1', 'Kcnq5',\n", " 'Tmsb10', 'Setbp1', 'Grm7', 'Fam184a', 'Ext1', 'Zc3h7a',\n", " 'C130071C03Rik', 'Lrrc4c', 'Trim9', 'Gabrg3', 'Plcb1', 'Fgf14',\n", " 'Paqr8', 'Srrm2', 'Khdrbs2', 'Magi2', 'Rgs6', 'Meg3', 'Npas3',\n", " 'Caln1', 'Kcnd2', 'Wdr17', 'Csmd2', 'Dlgap2', 'Grin2b', 'Sox6',\n", " 'Gnaq', 'Sbf2', 'Fam155a', 'Syne1', 'Unc79', 'Pard3b', 'Ptprd',\n", " 'Phactr1', 'Dennd1a', 'Magi3', 'Cttnbp2', 'Park2', 'Zcchc7',\n", " 'Sorbs1', 'Epha5', 'Esrrg', 'Adcy2', 'Asap1', 'Cacna1e', 'Ncam2',\n", " 'Pfkp', 'Robo1', 'Ptk2', 'Cdk8', 'Grin2a', 'Tmtc2', 'Arhgap26',\n", " 'Gucy1a2', 'Ank2', 'Slc35f1', 'Dnajc1', 'Nos1ap', 'Kcnh7',\n", " 'Pgm2l1', 'Frmd4a', 'Cntn4', 'Evi5', 'Gpc5', 'Efr3a', 'Nrg1',\n", " 'Pclo', 'Celf2', 'Rorb', 'Lmtk2', 'Kcnd3', 'Hs3st4', 'Scai',\n", " 'Map2', 'Tjp1', 'Dst', 'Vps13b', 'Cdc73', 'Cacnb4', 'Nrxn3',\n", " 'Cntn5', 'Gabrb1', 'Dmd', 'Slc1a2', 'Ppp2r2b', 'Ptprt', 'Tcf4',\n", " 'Phka1', 'Pitpnc1', 'Myo5a', 'Plekha5', 'Hdac4', 'Pnisr', 'Kcnh1',\n", " 'Otud7a', 'Dock4', 'Sh3gl2', 'Sik3', 'Tnik', 'Fmn2', 'Camk4',\n", " 'Rbfox1', 'Agbl4', 'Pid1', 'Macf1', '4930402H24Rik', 'Kcnn2',\n", " 'Gpm6a', 'Trpm3', 'Gli2', 'Galnt9', 'Meis2', 'Csmd1', 'Nmnat2',\n", " 'Pten', 'Etv5', 'Mmp16', 'Phf24', 'Dip2c', 'Appl2', 'Mcc', 'Lrp1b',\n", " 'Cdc42bpa', 'A330033J07Rik', 'Rgs7', 'Fry', 'Peg3', 'Dlg2', 'Pbx1',\n", " 'Pcdh7', 'Miat', 'Prex2', 'Plxna2', 'C230004F18Rik',\n", " 'A830018L16Rik', 'Camk2g', 'Prickle2', 'Bcl2', 'Tle4', 'Hivep3',\n", " 'Smyd3', 'Kctd16', 'Plpp3', 'Slc17a7', '2010111I01Rik', 'Ntrk2',\n", " 'Cacna1d', 'Nr4a2', 'Astn2', 'Kcnj6', 'Dlk1', 'Xylt1', 'Cdh18',\n", " 'Gabrb3', '9330182L06Rik', 'Satb2', 'Dcc', 'Kcnn3', 'Sgcd', 'Sdk2',\n", " 'Adam23', 'Slc6a3', 'Tnr', 'Th', 'Wnk2', 'Mical2', 'En1',\n", " 'Ppp1r12b', 'Nav2', 'Ogt', 'Fgfr2', 'Nyap2', 'Grik3', 'Galnt18',\n", " 'Cntnap5a', 'Fam189a1', 'Slc10a4', 'Malat1'], dtype=object),\n", " 'Pbx3(+)': array(['AW551984', 'C130021I20Rik', 'Slc39a4', 'Serpine2', 'Gucy2c',\n", " 'Pcbd1'], dtype=object),\n", " 'Pknox2(+)': array(['Lrrc7', 'Akt3', 'Cnksr2', 'Hivep2', 'Rfx3', 'Fbxw7', 'Rims2',\n", " 'Ube3a', 'Lingo2', 'Sgcz', 'Tanc2', 'Stag1', 'Adgrl3', 'Zfp385b',\n", " 'Ttc3', 'Syt1', 'Atxn1', 'Stxbp5l', 'Ccser1', 'Dlgap1', 'Fut9',\n", " 'Dpp10', 'Cacna2d1', 'Dab1', 'Nlgn1', 'Car10', 'Fgf12', 'Pparg',\n", " 'Rora', 'Thrb', 'R3hdm1', 'Nbea', 'Ralyl', 'Anks1b', 'Efna5',\n", " 'Sptan1', 'Foxp1', 'Cadm1', 'Ppp1r12a', 'Frmpd4', 'Sipa1l1',\n", " 'Prr16', 'Kcnt2', 'Fam19a2', 'Gria4', 'Gria2', 'Unc5d', 'Chsy3',\n", " 'Dok6', 'Sntg1', 'Lrfn5', 'Mdga2', 'Calm2', 'Nrcam', 'Arpp21',\n", " 'Oxr1', 'Epha6', 'Ppp3ca', 'Unc80', 'Cadps', 'Apba2', 'Adgrb3',\n", " 'Trhde', 'Trank1', 'Erc2', 'Cux1', 'Hecw1', 'Cacna2d3', 'Ube2e2',\n", " 'Nkain2', 'Herc1', 'Prkg1', 'Grm5', 'Kcnq3', 'Negr1', 'Cdh12',\n", " 'Cntnap2', 'Snap25', 'Brinp3', 'Syt14', 'Nol4', 'Pcdh9', 'Cadm2',\n", " 'Fnbp1l', 'Lmo4', 'Gls', 'Mef2c', 'Robo2', 'Atrnl1', 'Tenm4',\n", " 'Myrip', 'Grip1', 'Kcnj3', 'Rasal2', '9530059O14Rik', 'Dock3',\n", " 'Xkr4', 'Arid5b', 'Nrg3', 'Auts2', 'Macrod2', 'Ctnna2', 'Ppfia2',\n", " 'Ehbp1', 'Camta1', 'Grik2', 'Pde10a', 'Snap91', 'Nrxn1', 'Rims1',\n", " 'Ctnnd2', 'Dclk1', 'Kcnq5', 'Fstl4', 'Grm7', 'Ext1', 'Lrrc4c',\n", " 'Gabrg3', 'Plcb1', 'Fgf14', 'Srrm2', 'Hs6st3', 'Magi2', 'Meg3',\n", " 'Brinp1', 'Pcsk2', 'Kcnd2', 'Ppm1h', 'Csmd2', 'Dlgap2', 'Fam19a1',\n", " 'Grin2b', 'Scn8a', 'Fam155a', 'Syne1', 'Ptprd', 'Phactr1',\n", " 'Cttnbp2', 'Park2', 'Zcchc7', 'Epha5', 'Kirrel3', 'Prkar1b',\n", " 'Asap1', 'Cacna1e', 'Ncam2', 'Grin2a', 'Arhgap20', 'Arhgap26',\n", " 'Gucy1a2', 'Ank2', 'Kcnh7', 'Vamp2', 'Rtn1', 'Frmd4a', 'Cntn4',\n", " 'Osbpl3', 'Calm1', 'Nrg1', 'Celf2', 'Chrm3', 'Tbc1d30', 'Cacnb4',\n", " 'Nrxn3', 'Klhl29', 'Cntn5', 'Gabrb1', 'Clstn2', 'Slc2a13', 'Mapk1',\n", " 'Ppp2r2b', 'Ptprt', 'Tcf4', 'Plekha5', 'Kcnb1', 'Nptn', 'Otud7a',\n", " 'Zbtb16', 'Tnik', 'Fmn2', 'Camk4', 'Rbfox1', 'AI593442', 'Tmem108',\n", " 'Adam22', 'Agbl4', 'Cacna1c', 'Chn1', 'Camkk2'], dtype=object),\n", " 'Pou3f2(+)': array(['Ntm', 'Pou3f2', 'Slc6a3', 'Dlk1', 'Slc1a2', 'Ret', 'Gpc5', 'Glul',\n", " 'Ptn', 'En1', 'Msi2', 'Fam107a', 'Plpp3', 'Ddc', 'Aldh1a1'],\n", " dtype=object),\n", " 'Prox1(+)': array(['Kif26b', 'Slc39a6', 'Prox1', 'Lmo1', 'Stxbp6', 'Nt5dc2'],\n", " dtype=object),\n", " 'Prrx2(+)': array(['Tbx15', 'Slc26a7', 'H2-Aa', 'Car13', 'Igf2', 'Lbp', 'Zic2',\n", " 'Slc38a2', 'Anxa3', 'Col1a2', 'Ddr2'], dtype=object),\n", " 'Satb2(+)': array(['Kmt2e', 'Atp2b1', 'Slc39a10', 'Cdk17', 'Satb1', 'Lrrc7', 'Akt3',\n", " 'Cnksr2', 'Galnt13', 'Hivep2', 'Smarca2', 'Fbxw7', 'Rims2',\n", " 'Ube3a', 'Lingo2', 'Sgcz', 'Tanc2', 'Stag1', 'Sept7', 'Adgrl3',\n", " 'Kansl1', 'Zfp385b', 'Ttc3', 'Syt1', 'Atxn1', 'Stxbp5l', 'Pja2',\n", " 'Zfr', 'Ppp3cb', 'Ccser1', 'Dlgap1', 'Basp1', 'Btbd10', 'Fut9',\n", " 'Dpp10', 'Cacna2d1', 'Dab1', 'Nlgn1', 'Numb', 'Car10', 'Cdh8',\n", " 'Fgf12', 'Grm3', 'Pparg', 'Cdkl5', 'Pam', 'Thrb', 'Camk1d',\n", " 'R3hdm1', 'Nbea', 'Ralyl', 'Anks1b', 'Efna5', 'Il1rapl2', 'Sptan1',\n", " 'Foxp1', 'Cadm1', 'Wasf1', 'Ppp1r12a', 'Frmpd4', 'Sipa1l1',\n", " 'Prr16', 'Kcnt2', 'Fam19a2', 'Gria4', 'Gria2', 'Unc5d', 'Myo1b',\n", " 'App', 'Chsy3', 'Hecw2', 'Sntg1', 'Lrfn5', 'Ppp1r9a', 'Mdga2',\n", " 'Nectin3', 'Calm2', 'Ldlrad4', 'Kctd1', 'Nckap1', 'Nrcam',\n", " 'Gabrb2', 'Ppm1l', 'Arpp21', 'Oxr1', 'St6gal2', 'Ppp3ca', 'Unc80',\n", " 'Cadps', 'Apba2', 'Adgrb3', 'Npas2', '5730522E02Rik', 'Cadm3',\n", " 'Rock2', 'Fzd3', 'Trhde', 'Flrt2', 'Trank1', 'Gabra4', 'Erc2',\n", " 'Rab6a', 'Abi2', 'Enc1', 'Hecw1', 'Cacna2d3', 'Prkacb', 'Homer1',\n", " 'Ube2e2', 'Herc1', 'Prickle1', 'Grm5', 'Kcnq3', 'Large1', 'Negr1',\n", " 'Cdh12', 'Spats2l', 'Snap25', 'Brinp3', 'Syt14', 'Pcdh9', 'Cadm2',\n", " 'Fnbp1l', 'Lmo4', 'Gls', 'Mef2c', 'Robo2', 'Bcl11a', 'Atrnl1',\n", " 'Tenm4', 'Myrip', 'Kcnj3', 'Rasal2', 'Dock3', 'Ssh2', 'Gpc6',\n", " 'Xkr4', 'Stmn1', 'Sub1', 'Tspan7', 'March1', 'Atl1', 'Nrg3',\n", " 'Kcnmb4', 'Auts2', 'Macrod2', 'Tiam2', 'Ctnna2', 'Kif5c', 'Pak7',\n", " 'Map9', 'Dnaja1', 'Cpne8', 'Dmxl2', 'Adcy8', 'Ndrg3', 'Spred1',\n", " 'Pde10a', 'Snap91', 'Nrxn1', 'Osbpl1a', 'Rims1', 'Ctnnd2', 'Eml5',\n", " 'Nrn1', 'Rtn3', 'Dclk1', 'Nrep', 'Kcnq5', 'Ppp3r1', 'Agtpbp1',\n", " 'Fstl4', 'Setbp1', 'Grm7', 'Ext1', 'Atp8a1', 'Lrrc4c', 'Zbtb18',\n", " 'Trim9', 'Gabrg3', 'Plcb1', 'Fgf14', 'Ywhaz', 'Hs6st3', 'Khdrbs2',\n", " 'Rgs6', 'Celf1', 'Ptprk', 'Sept11', 'Meg3', 'Brinp1', 'Tsc22d1',\n", " 'Pcsk2', 'Caln1', 'Sptbn2', 'Kcnd2', 'Dlgap2', 'Fam19a1', 'Grin2b',\n", " 'Rasgef1b', 'Mark1', 'Ptpn5', 'Scn8a', 'Fam155a', 'Syne1', 'Unc79',\n", " 'Necab1', 'Arntl', 'Fam126b', 'Mkl2', 'Ptprd', 'Itpr1', 'Phactr1',\n", " 'Herc3', 'Epha5', 'Tshz3', 'Nlk', 'Prkar1b', 'Cdh6', 'Asap1',\n", " 'Pi4ka', 'Cacna1e', 'Mtpn', 'Pfkp', 'Ptk2', 'Nwd2', 'Grin2a',\n", " 'Fhl2', 'Arhgap26', 'Gucy1a2', 'Ank2', 'Nos1ap', 'Kcnh7', 'Vamp2',\n", " 'Serbp1', 'Pde8b', 'Pgm2l1', 'Rtn1', 'Cntn4', 'Extl3', 'Calm1',\n", " 'Serpini1', 'Nrg1', 'Pclo', 'Pkm', 'Celf2', 'Sorcs3', 'Gabra1',\n", " 'Adgrl1', 'Lmtk2', '2010300C02Rik', 'Rtn4', 'Chrm3', 'Smim13',\n", " 'Slc24a2', 'Hs3st4', 'Map2', 'Ncald', 'Ywhag', 'Ptn', 'Cacnb4',\n", " 'Trim37', 'Nrxn3', 'Cntn5', 'Epha4', 'Clstn2', 'Dmd', 'Slc2a13',\n", " 'Mapk1', 'Camkk2', 'Ppp2r2b', 'Ywhah', 'Ptprt', 'Tcf4', 'Myo5a',\n", " 'Kcnb1', 'Nptn', 'Hdac4', 'Micu3', 'Kcnh1', 'Otud7a', 'Sh3gl2',\n", " 'Zfp697', 'Fmn2', 'Rnf150', 'Camk4', 'Rbfox1', 'AI593442',\n", " 'Adam22', 'Agbl4', 'Cacna1c', 'Chn1', 'Nuak1', 'Wdr82', 'Sorcs1',\n", " 'Arfgef3', 'Sun1', 'Tusc3', 'Snrpn', 'Ptms', 'Gpm6a', 'Trio',\n", " 'Rab15', 'Nedd4l', 'Cyfip2', '1700020I14Rik', 'Csmd1', 'Pten',\n", " 'Phf24', 'Ryr2', 'Med13l', 'Tspoap1', 'Cdc42bpa', 'Slc6a17',\n", " 'Sphkap', 'Rgs7', 'Ngef', 'Dlg2', 'Pbx1', 'Pcdh7', 'Efhd2',\n", " 'Nell2', 'Gfra2', 'Ctnna3', 'Kcnh5', 'Miat', 'Rgs7bp', 'Fam49a',\n", " 'Plxna2', 'Frrs1l', 'C230004F18Rik', 'Pde4dip', 'Lamp5', 'Hdac9',\n", " 'Akap8l', 'Arhgef9', 'Camk2g', 'Prickle2', 'Kctd16', 'Nrsn1',\n", " 'Msra', 'Lancl2', 'Vopp1', 'Slc17a7', '2010111I01Rik', 'Serinc1',\n", " 'Cacna1d', 'Fhod3', 'Kcnma1', 'Pkd1', 'Fam49b', 'Arpp19', 'Cdh10',\n", " 'Vgf', 'Hpca', 'Mical2', 'Adam23', 'R3hdm2', 'Fam135b', 'St3gal5',\n", " 'Slit3', 'Sidt1', 'Sh3rf3', 'Gm1976', 'Prkce', 'Ptprs', 'Egfem1',\n", " 'Pcdha1', 'Malat1', 'Satb2', 'Ntm', 'Opcml', 'Ephb6', 'Coch',\n", " 'Sema7a', 'Trpc3', 'Cabyr', 'Lamc2', 'Lrrk2', 'Ankrd33b', 'Stard8',\n", " 'Ier5', 'Hipk4', 'Plekha6', 'Usp2', 'Igsf9b', 'Pantr1', 'Acsl5',\n", " 'Tnnt2', 'Frmd6', 'Mkx', 'Cd34', 'Cpne5', 'Kcnj9', 'Pamr1', 'Cux1',\n", " 'Ddit4l'], dtype=object),\n", " 'Sox10(+)': array(['Chn2', 'Dock10', 'Pacs2', 'Pdlim2', 'Sema6a', 'Desi1', 'Clic4',\n", " 'Tmem88b', 'Gpr37', 'Frmd8', 'Nfasc', 'Edil3', 'Fnbp1', 'Hhip',\n", " 'Mapk8ip1', 'Rnf13', 'Daam2', 'Plekhh1', 'Mt2', 'Ptgds', 'S100a16',\n", " 'Itpk1', 'Tprn', 'Adssl1', 'Dennd5a', 'Gsn', 'Tmbim1', 'Ddr1',\n", " 'Sema4d', 'Clmn', 'Cdc42ep2', 'Plxnb3', 'Plekhg3', 'Ppp1r16b',\n", " 'Mcam', 'Kndc1', 'Gng11', 'Tulp4', 'Abca2', 'Phactr3', 'Tmeff2',\n", " 'Elovl1', 'Gstm7', 'Ptma', 'Hcn2', 'Gjc2', 'Ptn', 'Smad7', 'Cd81',\n", " 'St6galnac3', 'Myrf', 'Pllp', 'Plat', 'Sox10', 'Rhou', 'Trf',\n", " 'Tppp3', 'Grb14', 'Ttll7', 'Gpr17', 'Fgf1', 'Nkx6-2', 'Cntn2',\n", " 'Dbndd2', 'Gab1', 'Ugt8a', 'Creb5', 'Cpox', 'Klk6', 'Gatm',\n", " 'Tspan2', 'Fth1', 'Scd2', 'Cnksr3', 'Ftl1', 'Mbp', 'Tmem229a',\n", " 'Csrp1', 'Sept7', 'Foxn3', 'Ppp1r14a', 'Otud7b', 'Rassf2', 'Efnb3',\n", " 'Il1rap', 'Rcbtb1', 'Tsc22d4', 'Carhsp1', 'Erbb3', 'Bcas1',\n", " 'Tmem63a', 'Lpar1', 'St18', 'Syt11', 'Nmral1', 'S100b', 'Bin1',\n", " 'Rdx', 'Kcnj10', 'Rhog', 'Olig2', 'Olig1', 'Arhgef10', 'Rhob',\n", " 'Cd9', 'Ankrd13a', 'Myo6', 'Anln', 'Slain1', 'Gltp', 'Serpinb1a',\n", " 'Car2', '5031439G07Rik', 'Gabrr2', 'Atp1b3', 'Pde4b', 'Plin3',\n", " 'Galnt6', 'Opalin', 'Rtkn', 'Traf5', '2700046A07Rik', 'Plp1',\n", " 'Gstp1', 'Zdhhc9', 'Gna12', 'Plekhb1', 'Ndrg1', 'Tubb4a', 'Mal',\n", " 'Sgk1', 'Mobp', 'Qdpr', 'Gprc5b', 'Nkain1', 'D16Ertd472e',\n", " 'Secisbp2l', 'Fa2h', 'Enpp6', 'Tns3', 'Scd1', 'Cd82', 'Sept4',\n", " 'Scrg1', 'Cryab', 'Pde8a', 'Arhgap23', 'Sparc', 'Rcan2', 'Cers2',\n", " 'Map4k4', 'Tmem123', 'Gjb1', 'Padi2', 'Mast4', 'Phgdh', 'Sec14l5',\n", " 'Ano4', 'Plekha1', 'Unc5b', 'Zfp536', 'Fez1', 'Qk', 'Tmod1',\n", " 'Sez6l2'], dtype=object),\n", " 'Sox9(+)': array(['Id3', 'Tmem47', 'Atp1a2', 'Rassf3', 'Slc6a1', 'Id4', 'Cldn10',\n", " 'Fgfr3', 'Oaf', 'Syn3', 'Clu', 'Slc1a2', 'Mlc1', 'Fgfr1', 'Mfge8',\n", " 'Sox9'], dtype=object),\n", " 'Srebf1(+)': array(['Atp1a2', 'Qk', 'Aldoc', 'Clu', 'Cst3', 'Paqr8'], dtype=object),\n", " 'Tbx18(+)': array(['Igf2', 'Fbln1', 'Serpinf1', 'Tbx18', 'Col1a2', 'Elf1', 'Zic2',\n", " 'Osr1', 'Lrp1', 'Cald1', 'Bgn'], dtype=object),\n", " 'Tcf4(+)': array(['Gphn', 'Snap25', 'Cadm2', 'Syt1', 'Lsamp', 'Dlg2', 'Nrg3',\n", " 'Magi2', 'Setbp1', 'Cd44', 'Dok6', 'Camk1d', 'Nrxn1', 'Gria2',\n", " 'Cdh2', 'Ctnnd2', 'Hsp90ab1', 'Tmsb4x'], dtype=object),\n", " 'Tcf7l2(+)': array(['Otx2', 'Gata3', 'Zfhx3', 'Tcf7l2', 'Zfhx4', 'Pax3', 'Lhx1os',\n", " 'Cbln2', 'Six3', 'Calb2', 'Htr2c', 'AW551984', 'Slc17a6',\n", " 'Mab21l2', 'Tal1', 'Syndig1l', 'Glra1', 'Steap2', 'Chrm2',\n", " 'Klhl13', 'Scn4b', 'Fign', 'Zcchc12', 'Cacna2d2', 'Patj', 'Pnoc',\n", " 'Prkcd', 'Esrrb', 'Plxnb3', 'Abat', 'Nrsn2', 'Smim17', 'Arhgap36',\n", " 'Ctxn3', 'Phlda3', 'Pld5', 'Enpp6', 'Kat2b', 'Cygb', 'Rasgrp2',\n", " 'Camk2n2', 'Nacc2', 'Nova1', 'Rgs10', 'Scd1', 'Cnksr3', 'Tmem163',\n", " 'Irx1', 'Svs5', 'Cd59a', 'Rgs16', 'Foxp2', 'Gad2', 'Zic1',\n", " 'Sema6a', 'Gphn', 'Plp1', 'Ntng1', 'Rbms3', 'Kcnj10', 'Hdac8',\n", " 'Cdh20', 'Kcnc1', 'Rmst', 'Atp1a2', 'Camta1', 'Grid2', 'Ntsr2',\n", " 'Mal', 'Camk1d', 'Rora', 'Aqp4', 'Aldoc', 'Nefm'], dtype=object),\n", " 'Thra(+)': array(['Dapk1', 'Syt1', 'Cdk17', 'Ccnd2', 'Slitrk5', 'Ttc3', 'Lmo4',\n", " 'Chd3', 'Meg3', 'Fbxw7', 'Zfr', 'Tceal9', 'Arf3', 'Basp1', 'Jph4',\n", " 'Tceal3', 'Stmn2', 'Pja2', 'Gnb2', 'Pafah1b1', 'Cadm3', 'Prmt8',\n", " 'Cadm1', 'Bex3', 'Smarca2', 'Atp2b1', 'Snca', 'Thra', 'Ppp3ca',\n", " 'Slc39a10', 'Cacna1e', 'Dpf1', 'Sipa1l1', 'Shank1', 'Grin2b',\n", " 'Chrm1', 'Vamp2', 'Tceal6', 'Ywhae', 'Anp32a', 'Nrn1', 'Morf4l2',\n", " 'Rab6a', 'Nlgn2', 'Abr', 'Gnas', 'Bcl11a', 'Matr3', 'Abi2',\n", " 'Gpr162', 'Tlk1', 'Hspa8', 'Snap25', 'Tcf4', 'Stmn4', 'H2afz',\n", " 'Nrxn2', 'Anks1b', 'Hnrnpk', 'Adgrl1', 'Ywhag', 'Cacng8', 'Gria3',\n", " 'Tsc22d1', 'Erc2', 'Adgrb2', 'Cnksr2', 'Ildr2', 'Tceal5', 'Set',\n", " 'Vgf', 'Gap43', 'Scn3b', 'Mef2c', 'Cntn1', 'Capza2', 'Gabbr1',\n", " 'Arhgef9', 'Nap1l1', 'App', 'March6', 'Cd47', 'Gria2', 'Celf5',\n", " 'Nlgn1', 'Grin2a', 'Usp46', 'Gnao1', 'Calm2', 'Dlg4', 'Gabra2',\n", " 'Kif1a', 'Bex1', 'Wasf1', 'Ppp3cb', 'Cnih2', 'Miat', 'C1ql3',\n", " 'Ndrg3', 'Acsl4', 'Nfib', 'Egr3', 'Hsp90ab1', 'Eloc', 'Prkar1b',\n", " 'Pnck', 'Tmem50a', 'Hprt', 'Fscn1', 'Prkar1a', 'Camk2b', 'Ywhaz',\n", " 'Cplx2', 'Cltc', 'Nlgn3', 'Sptan1', 'Bcl11b', 'Rtn4', 'Camk2d',\n", " 'Bhlhe22', 'Nptn', 'Chst1', 'Maged1', 'Cdk5r2', 'Myh7', 'Mapre3',\n", " 'Ptms', 'Pcdh8', 'Unc13a', 'Pls3', 'Grik5', 'Ppp1r9a', 'Pkm',\n", " 'Ptprs', 'Nckap5', 'Ssh2', 'Chn1os3', 'Syngap1', 'Syp', 'Syt11',\n", " 'Tpm1', 'Ube2e3', 'Enpp5', 'Atxn10', 'Tenm4', 'B3gat1', 'Dyrk2',\n", " 'Tmem35a', 'Pdcd4', 'Arhgef28', 'Slc6a15', 'Dmtn', 'Neurod2',\n", " 'Ncald', 'Ube2w', 'Cacnb3', 'Ctnnb1', 'Rtn3', 'Slc17a7', 'Ppp3r1',\n", " 'Mlf2', 'Pea15a', 'Kcnh3', 'Fam19a1', 'Gls', 'Grasp', 'Fam171b',\n", " 'Rin1', 'Negr1', 'Grm5', 'Pcdh19', 'Nckap1', 'Hpcal4', 'Cdc42se2',\n", " 'Sorbs2', 'Atp1a3', 'Actr3', 'Ddn', 'Sfr1', 'Gpr39', 'Mmp17',\n", " 'Enc1', 'Gdi1', 'Homer1', 'Adam11', 'Crmp1', 'Sprn', 'Psip1',\n", " 'Bex2', 'Prkacb', 'Ankhd1', 'Sub1', 'Prnp', 'Thy1', 'Dlgap4',\n", " 'Palm', 'Syt17', 'Prkaca', 'Snrpn', 'Gpd2', 'Eif5a', 'Rps23',\n", " 'Pter', 'Prpf39', 'Celf3', 'Syn1', 'Calm3', 'Arpp21', 'Syt7',\n", " 'Gnl3l', 'Ppp1r9b', 'Eef1a1', 'Pcbp1', 'Fxyd7', 'Serpini1',\n", " 'Itm2c', 'Dlgap1', 'Akirin2', 'Dcaf7', 'Nptxr', 'Dnm1', 'Lrfn5',\n", " 'Smad3', 'Stxbp1', 'Tsnax', 'Slc22a17', 'Rab26', 'St3gal5',\n", " 'Pgrmc1', 'Atpif1', 'Ube2b', 'Jph3', 'Akap8l', 'Sult4a1', 'Tomm20',\n", " 'Tusc3', 'Mras', 'Rab3b', 'Pfn2', 'Actn1', 'B3galt2', 'Rapgefl1',\n", " 'Psma1', 'Klhl2', 'Prkcg', 'Arl6ip1', 'Rheb', 'Synpr', 'Akap11',\n", " 'Atp5a1', 'Chl1', 'Sertm1', 'Ppme1', 'Eno2', 'Efhd2', 'Galnt9',\n", " 'Celsr2', 'Pcsk2', 'Plppr4', 'Camk2n1', 'Map2', 'Gpm6a', 'Slc8a2',\n", " 'Nos1', 'Nsg2', 'Ptprn', 'Mef2d', 'Cnih3', 'Mpc2', 'Pgm2l1',\n", " 'Baiap2', '4930481A15Rik', 'Ryr3', 'Tmsb4x', 'Ndrg4', 'Grp',\n", " 'Ramp2', 'Rpl29', 'Scamp5', 'Dcn', 'Ap2b1', 'Bsg', 'Ppp2r2c',\n", " 'Atp6v1a', 'Syt4', 'Hpca', 'Slc15a3', 'Tpm3', 'Ckmt1', 'Fez1',\n", " 'Prex1', 'Cnr1', 'Rpl6', 'Marcks', 'Neurl1a', 'Ppp1r1a', 'Lingo1',\n", " 'Ipo5', 'C1qtnf4', 'Crtac1', 'Pam', 'Gria1', 'Camta2', 'Arpc2',\n", " 'Rwdd1', 'Fabp3', 'Fzd3', 'Atp6ap1', 'Kcnma1', 'Ndufv2', 'Syn2',\n", " 'Caln1', 'Snx10', 'Slc12a5', 'Tcaf1', 'Amph', 'Adcy1', 'Atp6v1c1',\n", " 'Clip3', 'Gpm6b', 'Synj1', 'Dlg3', 'Cers1', 'Nov', 'Scn2a',\n", " 'Map1b', 'Dynlrb1', 'Hspa2', 'Cacna2d1', 'Apbb1', 'Dnaja1',\n", " 'Pcsk5', 'Prkce', 'Dclk1', 'Ndufb5', 'Ppp1cb', 'Slc7a14', 'Hpcal1',\n", " 'Shank2', 'Nucks1', 'Mapk8ip2', 'Ran', 'Pnrc1', 'Slit1', 'Cdc42',\n", " 'Cyfip2', 'Cpne6', 'Mea1', 'Rps10', 'Rps21', 'Dbn1', 'Ywhab',\n", " 'Kcnip2', 'Rab2a', 'Calb1', 'Hrk', 'Ssbp4', 'Prkca', 'Celf1',\n", " 'Zbtb18', 'Ociad1', 'Emc2', 'Ubb', 'Hap1', 'Arhgef25', 'Rtn4rl1',\n", " 'Cyth2', 'Sirpa', 'Dynlt3', 'Ubxn11', 'Eif1', 'Gprin1', 'Ptpra',\n", " 'Hk1', 'Adprh', 'Atp1b1', 'Ubqln2', 'Snn', 'Rps16', 'Hnrnpa3',\n", " 'Sncb', 'Ankrd63', 'Arl6ip5', 'Plppr2', 'Sptbn2', 'Fbxl16',\n", " 'Sez6l', 'Atp2b4', 'Rilpl1', 'Rpl36', 'Ephx4', 'Ppm1e', 'Mal2',\n", " 'Serinc1', 'Ccl27a', 'Mkl2', 'Ppp1r2', 'Polr1d', 'Atl1', 'Elmod1',\n", " 'Pfn1', 'Ptk2b', 'Atp1a1', 'Mtpn', 'Psd', 'Rasal1', 'Arpc4',\n", " 'Foxg1', 'H3f3b', 'Reps2', 'Tspan13', 'Psmb3', 'Fam131a',\n", " '3300002P13Rik', 'Cryl1', 'Eef1a2', 'Cmas', 'Rasgrp1', 'Nptx1',\n", " 'Fars2', 'Gnb1', 'Coro1a', 'Camk2a', 'Park7', 'Actb', 'Actr2',\n", " 'Rab15', 'Nsg1', 'Tex264', 'Dynll1', 'Vti1b', 'Synpo', 'Rap2b',\n", " 'Clstn1', 'Atp5j', 'Itpka', 'Rnf112', 'Celf2', 'Strn4', 'Grin1',\n", " 'Tesc', 'Dctn2', 'Pi4ka', 'Csnk1a1', 'Rbfox3', 'Tbca', 'Opcml',\n", " 'Gabrb3', 'Stk11', 'Sez6', 'Stum', 'Chmp4b', 'Aes', 'Cbarp',\n", " 'Caly', 'Serp2', 'Creg2', 'Rhob', 'Wdr89', 'Atp5g1', 'Npy',\n", " 'Trim32', 'Rpl38', 'Serbp1', 'Clcn4', 'Wfs1', 'Meis2', 'Atp5d',\n", " 'Astn1', 'Eif4a2', 'Tuba4a', 'Dbp', 'Nr2f1', 'Lamp5', 'Nrgn',\n", " 'Pfkl', 'Timp2', 'Ndufb7', 'Celf4', 'Tpi1', 'Pfkp', 'Atp6v1d',\n", " 'Rasgrf1', 'Slc6a17', 'Mllt11', 'Ppp5c', 'Mapk3', 'Kcnj4', 'Gpr22',\n", " 'Brk1', 'Tomm70a', 'Ensa', 'Ube2ql1', 'Rasgef1a', 'Phykpl', 'Nsf',\n", " 'Rbbp7', 'Dennd6b', 'Atp9a', 'Dgkz', 'Sptbn1', 'Tyro3', 'Adgrd1',\n", " 'Oxct1', 'Atp6v1b2', 'Phyhip', 'Rasl10a', 'Arpc5', 'Khdrbs3',\n", " 'Mapk1', 'Calr', 'Vstm2l', 'Trim2', 'Rps26', 'Slc25a22', 'Dgkg',\n", " 'Ap1s1', 'R3hdm4', 'Atp8a1', 'Nfyb', 'Tbc1d9', 'Eif4h', 'Sdhb',\n", " 'Nme2', 'Ncoa1', 'Cyp46a1', 'C2cd2l', 'B4galt6', 'Ldha', 'Klc1',\n", " 'Calm1', 'Lrrtm1', 'Svop', 'Fam163b', 'Plec', 'Ppia', 'Myo5b',\n", " 'Chn1', 'Rtn4r', 'Zfp706', 'Fxyd6', 'Nhp2', 'Txn1', 'Gabarapl1',\n", " 'Madd', 'Dpysl2', 'Eif1b', 'Cpe', 'Rpl19', 'Hnrnpab', 'Fam49a',\n", " 'Sort1', 'Rpl17', 'Hdac11', 'Rps7', 'Cttn', 'Olfm1', 'Kcnc4',\n", " 'Pgbd5', 'Klf13', 'Gnaq', 'Sdc3', 'Rpl11', 'Camkv', 'Gng13',\n", " 'Rprm', 'Tspan7', 'Arl4a', 'Gabra5', 'Sv2b', 'Cbx6', 'Cdh13',\n", " 'Cnrip1', 'Stmn1', 'Junb', 'Sh3gl2', 'Spock2', 'Rab6b', 'Fam81a',\n", " 'Ctsb', 'Myt1l', 'Kcnf1', 'Napa', 'Galnt16', 'Dnajb6', 'Mtch1',\n", " 'Nell2', 'Tagln3', '1700037H04Rik', 'Rtn1', 'Eno1', 'Nedd4l',\n", " 'Lancl2', 'Fam84a', '2010300C02Rik', 'Slc4a10', 'Slc25a4', 'Gnaz',\n", " 'Kalrn', 'Frrs1l', 'Ndufa10', 'Sqstm1', 'Mff', 'Slc30a3', 'Arf1',\n", " 'Ak5', 'Med26', 'Tubb2a', 'Ncan', 'Kif5a', 'Nme1', 'Apaf1',\n", " 'Map2k1', 'Hsp90aa1', 'Nos1ap', 'Mgst3', 'Cycs', 'Pdss2', 'Scoc',\n", " 'Ogfrl1', 'Ppp2ca', 'Vdac1', 'Slc25a3', 'Rpl37', 'Aak1', 'Rpl21',\n", " 'Hspa5', 'Spcs1', 'Rangap1', 'Gas7', 'Cox6c', 'Rpl31', 'Pja1',\n", " 'Atp5g3', 'Ypel3', 'Cadps2', 'Tspan3', 'Sem1', 'Tmx4', 'Arl8b',\n", " 'Ssb', 'Ly6h', 'Minos1', 'Ap2s1', 'Ier3ip1', 'Tuba1a', 'Rpl30',\n", " 'Ywhah', 'Angel1', 'Phf24', 'Cpne7', 'Gm5441', 'Lgi1', 'Ppp2r1a',\n", " 'Ociad2', 'Itm2b', 'Vps29', 'Ndufb6', 'Ap2m1', 'Ndufb3', 'Cetn3',\n", " 'Arl3', 'Tuba1b', 'Mat2b', 'Mtf1', 'Icam5', 'Uchl1', 'Fabp5',\n", " 'Gapdh', 'Rps20', 'Cspg5', 'Kcnq2', 'Gadl1', 'Lrp11', 'Ccsap',\n", " 'Cacybp', 'Akap5', 'Capzb', 'Fcho1', 'Napb', 'Lancl1', 'Trh',\n", " 'Ap2a2', 'Mpped1', 'Kifap3', 'Rab3c', 'Skp1a', 'Fibcd1', 'Otub1',\n", " 'Tmem191c', 'Pkig', 'Ndufa6', 'Chgb', 'Gal3st3', 'Selenow',\n", " 'Atp5k', 'Tmem59l', 'Rpl39', 'Marcksl1', 'Fam189a1', 'Nme7',\n", " 'Arhgap32', 'Rpl5', 'Nek6', 'Pcsk1n', 'Ssr2', 'Rpl18a', 'Tmem30a',\n", " 'Snap47', 'Ncdn', 'Gpx4', 'Limd2', 'Ttc9b', 'Dkk3', 'Aplp1',\n", " 'Stmn3', 'Pitpna', 'Ssu72', 'Syt16', 'Tubb5', 'Rps14', 'Pcp4',\n", " 'Med28', 'Atp6ap2', 'Prkcb', 'Ids', 'Cox6b1', 'Kctd4', 'Pdcd5',\n", " 'Rps15a', 'Psmb6', 'Psmb1', 'Tspyl1', 'Swi5', 'Pnmal2', 'Ccdc106',\n", " 'Pop5', 'Pde1a', 'Actr3b', 'Pnmal1', 'Ctbp1', 'Dctn6', 'Cfl1',\n", " '6330403K07Rik', 'Ndufv3', 'Stx1a', 'Matk', 'Cbr1', 'Arpp19',\n", " 'Sowaha', 'Bsn', 'Rpl3', 'Mapk8ip3', 'Rps13', 'Dctn3', 'Strap',\n", " 'Rpl27', 'Tmem38a', 'Rps19', 'Car11', 'Hras', '6530403H02Rik',\n", " 'Arpc3', 'Lrpap1'], dtype=object),\n", " 'Thrb(+)': array(['Kmt2e', 'Atp2b1', 'Satb1', 'Dtna', 'Lrrc7', 'Akt3', 'Cnksr2',\n", " 'Galnt13', 'Hivep2', 'Rims2', 'Ube3a', 'Lingo2', 'Sgcz', 'Tanc2',\n", " 'Kat6b', 'Stag1', 'Adgrl3', 'Kansl1', 'Zfp385b', 'Ttc3', 'Enox1',\n", " 'Syt1', 'Atxn1', 'Stxbp5l', 'Runx1t1', 'Grid2', 'Pja2', 'Ccser1',\n", " 'Mapk8', 'Mctp1', 'Hook1', 'Dlgap1', 'Fut9', 'Dpp10', 'Cacna2d1',\n", " 'Dab1', 'Nlgn1', 'Msi2', 'Car10', 'Cdh8', 'Fgf12', 'Trpc4', 'Grm3',\n", " 'Pam', 'Rora', 'Osbpl6', 'Thrb', 'Camk1d', 'R3hdm1', 'Nbea',\n", " 'Ralyl', 'Anks1b', 'Efna5', 'Il1rapl2', 'Sptan1', 'Foxp1', 'Cadm1',\n", " 'Ppp1r12a', 'Grm8', 'Xkr6', 'Ncor1', 'Frmpd4', 'Sipa1l1', 'Prr16',\n", " 'Kcnt2', 'Gria4', 'Mllt3', 'Gria2', 'Unc5d', 'Ssbp2', 'App',\n", " 'Chsy3', 'Peak1', 'Hecw2', 'Dok6', 'Tox', 'Sntg1', 'Lrfn5',\n", " 'Ppp1r9a', 'Mdga2', 'Arl15', 'Calm2', 'Zeb1', 'Ldlrad4', 'Diaph2',\n", " 'Nrcam', 'Gabrb2', 'Ppm1l', 'Arpp21', 'Oxr1', 'Epha6', 'Ppp3ca',\n", " 'Unc80', 'Cadps', 'Apba2', 'Adgrb3', '5730522E02Rik', 'Nxph1',\n", " 'Rock2', 'Trhde', 'Flrt2', 'Trank1', 'Erc2', 'Hecw1', 'Cacna2d3',\n", " 'Prkacb', 'Homer1', 'Ube2e2', 'Nkain2', 'Jarid2', 'Herc1', 'Prkg1',\n", " 'Prickle1', 'Ahi1', 'Grm5', 'Kcnq3', 'Large1', 'Negr1', 'Phf20l1',\n", " 'Cdh12', 'Cntnap2', 'Snap25', 'Brinp3', 'Syt14', 'Nol4', 'Pcdh9',\n", " 'Cadm2', 'Fnbp1l', 'Lmo4', 'Gls', 'Mef2c', 'Robo2', 'Bcl11a',\n", " 'Hcn1', 'Atrnl1', 'Tenm4', 'Farp1', 'Myrip', 'Ptchd4', 'Magi1',\n", " 'Grip1', 'Kif21a', 'Kcnj3', 'Rasal2', 'Dock3', 'Mapk4', 'Gpc6',\n", " 'Xkr4', 'Tspan7', 'March1', 'Nrg3', 'Mapt', 'Auts2', 'Macrod2',\n", " 'Ctnna2', 'Pak7', 'Ppfia2', 'Ehbp1', 'Camta1', 'Dmxl2', 'Grik2',\n", " 'Adcy8', 'Asap2', 'Ndrg3', 'Unc5c', 'Pde10a', 'Nrxn1', 'Osbpl1a',\n", " 'Rims1', 'Sobp', 'Ctnnd2', 'Zfp804b', 'Dclk1', 'Kcnq5', 'Fstl4',\n", " 'Setbp1', 'Grm7', 'Ext1', 'Zc3h7a', 'C130071C03Rik', 'Lrrc4c',\n", " 'Trim9', 'Gabrg3', 'Plcb1', 'Fgf14', 'Ywhaz', 'Srrm2', 'Dync1i1',\n", " 'Mtcl1', 'Hs6st3', 'Magi2', 'Rgs6', 'Celf1', 'Sept11', 'Meg3',\n", " 'Npas3', 'Brinp1', 'Pcsk2', 'Caln1', 'Kcnd2', 'Tnrc6c', 'Wdr17',\n", " 'Csmd2', 'Dlgap2', 'Fam19a1', 'Grin2b', 'Rasgef1b', 'Sox6',\n", " 'Mtus2', 'Sbf2', 'Scn8a', 'Fam155a', 'Syne1', 'Unc79', 'Fam126b',\n", " 'Mkl2', 'Ptprd', 'Itpr1', 'Phactr1', 'Ncoa1', 'Immp2l', 'Magi3',\n", " 'Cttnbp2', 'Herc3', 'Park2', 'Zcchc7', 'Sorbs1', 'Epha5', 'Tshz3',\n", " 'Kirrel3', 'Gm20754', 'Esyt2', 'Nlk', 'Prkar1b', 'Adcy2', 'Asap1',\n", " 'Cacna1e', 'Mtpn', 'Ncam2', 'Robo1', 'Ptk2', 'Htr1f', 'Grin2a',\n", " 'Clasp2', 'Tmtc2', 'Arhgap26', 'Gucy1a2', 'Ank2', 'C2cd5',\n", " 'Dnajc1', 'Nos1ap', 'Kcnh7', 'Slc24a4', 'Rtn1', 'Frmd4a', 'Cntn4',\n", " 'Slc35f4', 'Gpc5', 'Serpini1', 'Efr3a', 'Nrg1', 'Nebl', 'Pclo',\n", " 'Celf2', 'Gabra1', 'Dgkh', 'Lmtk2', 'Mbnl2', 'Myo16', 'Chrm3',\n", " 'Slc24a2', 'Hs3st4', 'Scai', 'Ttc14', 'Tjp1', 'Vps13b', 'Appl1',\n", " 'Cacnb4', 'Nrxn3', 'Klhl29', 'Cntn5', 'Gabrb1', 'Dmd', 'Slc2a13',\n", " 'Ppp2r2b', 'Ptprt', 'Tcf4', 'Myo5a', 'Plekha5', 'Nptn', 'Pnisr',\n", " 'Kcnh1', 'Otud7a', 'Dock4', 'Sh3gl2', 'Dlc1', 'Exoc5', 'Sik3',\n", " 'Ccdc85a', 'Tnik', 'Fmn2', 'Rnf150', 'Camk4', 'Rbfox1', 'Adam22',\n", " 'Agbl4', 'Macf1', 'Cacna1c', 'Adcy7', 'Chn1', 'Ptprm',\n", " '4930402H24Rik', 'Sorcs1', 'Kcnn2', 'Gpm6a', 'Trio', 'Trpm3',\n", " 'Nedd4l', 'Cyfip2', 'Cdk14', 'Csmd1', 'Pten', 'Mmp16', 'Phf24',\n", " 'Dip2c', 'Ryr2', 'Med13l', 'Lrp1b', 'Cdc42bpa', 'Slc6a17',\n", " 'Carmil1', 'Rgs7', 'Fry', 'Dlg2', 'Pbx1', 'Pcdh7', 'Sybu', 'Nell2',\n", " 'Ctnna3', 'Kcnh5', 'Miat', 'Fam49a', 'C230004F18Rik', 'Hdac9',\n", " 'Akap8l', 'Mycbp2', 'Camk2g', 'Ttll6', 'Syn1', 'Adgrb1',\n", " 'Prickle2', 'Hivep3', 'Arid1b', 'Smyd3', 'Lrch1', 'Kctd16', 'Msra',\n", " '2010111I01Rik', 'Dpp6', 'Fam193a', 'Cacna1d', 'Fhod3', 'Kcnma1',\n", " 'Fam49b', 'Cdh10', 'Mical2', 'Adam23', 'R3hdm2', 'Fam135b', 'Tia1',\n", " 'Slit3', 'Sidt1', 'Sh3rf3', 'Prkce', 'Egfem1', 'Tspan5', 'Slit2',\n", " 'Tshz2', 'Unc13b', 'Pde4d', 'Pacsin1', 'N4bp2l2', 'Pde1a', 'Syt16',\n", " 'Mapk10', 'Cdh18', 'Xist', 'Astn2', 'Cit', 'Sgip1', 'Ndst3', 'Ogt',\n", " 'Mir124a-1hg', 'Grik1', 'Nrgn', 'Galnt18', 'Vsnl1', 'Ntrk3',\n", " 'Ldb2', 'Cux2', 'Atp2b2', 'Lingo1', 'Dcc', 'Fgfr2', 'Lsamp',\n", " 'Pknox2', 'Cacna1a', 'Gria3', 'Gabrb3', 'Dgki', 'Cobl', 'Ksr2',\n", " 'Cpeb3', 'Sox5', 'Camk2n1', 'Dlg1', 'Pcdh15', 'Myt1l', 'Psd3',\n", " 'Rnf169', 'Adgrl2', 'Hdac8', 'Ptprg', 'Rbfox3', 'Xylt1', 'Plppr4',\n", " 'Rasgrf1', 'Samd12', 'Ptprn2', 'Satb2', 'Aak1', 'Cacng3', 'Dnm1',\n", " 'Shank2', 'Asic2', 'Nav2', 'Sv2b', 'Ntm', 'Csmd3', 'Slc4a10',\n", " 'Eif4g3', 'Gramd1b', 'Camk2a', 'Kcnip4', 'Grin1', 'Rimbp2', 'Rarb',\n", " 'Il1rapl1', 'D430041D05Rik', 'Sgcd', 'Chd5', 'Wnk2', 'Gria1',\n", " 'Kalrn', 'Ddx17', 'Arhgap32', 'Gpr158', 'Sorbs2', 'Slc8a1',\n", " 'Pex5l', 'D130009I18Rik', 'Mgat4c', 'Id2', 'B3galt1', 'Ftx',\n", " 'Cntnap5a', 'Tmem132b', 'Csrnp3', 'Copg2', 'Mdh1', 'Etl4',\n", " 'Lrrtm4', 'Astn1', 'Pdzrn3', 'Klf12', 'Cmss1', 'Galntl6', 'Srpk2',\n", " 'Malat1', 'Scn2a', 'Tenm3', 'Dscam', 'Scn1a', 'Nyap2', 'Tmem132d',\n", " 'Srsf11', 'Prkcb', 'Fam189a1', '1600010M07Rik', 'Adgra1'],\n", " dtype=object),\n", " 'Vsx1(+)': array(['Osr1', 'Zic4', 'Foxd2', 'Igfbp5', 'Col1a1', 'Tfap2a', 'Fn1',\n", " 'Bmp5', 'Pdzk1ip1', 'Gm5860', 'Nfatc4', 'Thsd4', 'Bmp7', 'Slc9a2',\n", " 'Krt80', 'Dapl1', 'Foxp2', 'Bgn', 'Slc26a7', 'Slc26a2', 'Col6a2',\n", " 'Tbx15', 'Lypd2', 'Foxc1'], dtype=object)}" ] }, "execution_count": 31, "metadata": {}, "output_type": "execute_result" } ], "source": [ "adata.uns['regulon_dict']" ] }, { "cell_type": "markdown", "id": "ff55ef4e", "metadata": {}, "source": [ "Receptors of each regulon were stored in adata.uns under key `receptor_dict` in dictionary format." ] }, { "cell_type": "code", "execution_count": null, "id": "f572ee04-8bce-4811-859f-0df1335dcc91", "metadata": {}, "outputs": [ { "data": { "text/plain": [ "{'Atf2': array(['Scn2a', 'Scn1a', 'Dscam', 'Cacna1b', 'Lrrtm4', 'Cacna1c', 'Ntm',\n", " 'Atp1a3', 'Il31ra', 'Nrsn1', 'Il1rapl1', 'Scn2b', 'Opcml', 'Sv2b',\n", " 'Stx1a', 'Adam23'], dtype=object),\n", " 'Atf4': array(['Gp1bb', 'Thy1', 'Nptn', 'Rtn4', 'Nptxr', 'Sv2b', 'Stx1a', 'App',\n", " 'Lingo1'], dtype=object),\n", " 'Bcl11a': array(['Gp1bb', 'Sirpa', 'Scn2a', 'Tyro3', 'Dscam', 'Scn1b', 'Il1rapl1',\n", " 'Lrp11', 'Opcml', 'Sv2b', 'Stx1a', 'Tmem59l'], dtype=object),\n", " 'Bcl6': array(['Ptprt', 'F3', 'Mertk'], dtype=object),\n", " 'Bnc2': array(['Mrc2', 'Thbd', 'Tgfbr3', 'Asgr1', 'Anxa2', 'Cd36', 'Slc6a12'],\n", " dtype=object),\n", " 'Cebpb': array(['Neurod2', 'C1ql2', 'Olfm1', 'Ppp3ca', 'Hpca', 'Rfx3', 'Snca',\n", " 'Wasf1', 'Sema5a', 'Prox1', 'Calm2', 'Ppfia2', 'Bex2', 'Camk2b',\n", " 'Pter', 'C1ql3', '2010300C02Rik', 'Dsp', 'Ppp1r1a', 'Nrgn',\n", " 'Cpne6', 'Chn1', 'Dgkh', 'Dynll1', 'Rps7', 'Cebpb', 'Tmsb4x',\n", " 'Ncdn'], dtype=object),\n", " 'Cebpd': array(['Grin2a', 'Adcy1', 'Crlf1'], dtype=object),\n", " 'Dbp': array(['Gp1bb', 'Camk2a', 'Scn1b', 'Nptxr', 'Sv2b', 'Stx1a', 'Lingo1',\n", " 'Nrxn1'], dtype=object),\n", " 'Dlx1': array([], dtype=float64),\n", " 'Ebf1': array(['Flt1', 'Cldn5'], dtype=object),\n", " 'Egr1': array(['Gp1bb', 'Rtn4r', 'Ephb6', 'Scn1b', 'Pcdhga1', 'Lrp11', 'Chrm3',\n", " 'Cckbr', 'Igsf9b'], dtype=object),\n", " 'Egr3': array(['Gp1bb', 'Sirpa', 'Rtn4r', 'Tspan5', 'Kcnj4', 'Sort1', 'Pde1a',\n", " 'Scn1b', 'Atp6ap2', 'Sv2b', 'Stx1a', 'Tmem59l', 'Cckbr', 'Nectin3',\n", " 'Adcy1'], dtype=object),\n", " 'Egr4': array(['Gp1bb', 'Lingo1', 'Sv2b', 'Nptxr'], dtype=object),\n", " 'Elk1': array(['Gp1bb', 'Plxna4', 'Camk2a', 'Lrfn5', 'Grin2a', 'Nptxr', 'Crlf1',\n", " 'Epha7', 'Lingo1'], dtype=object),\n", " 'En1': array(['Il13ra1', 'F2r'], dtype=object),\n", " 'Ets2': array(['Gp1bb', 'Camk2a'], dtype=object),\n", " 'Etv1': array(['Epha5', 'Tspan13', 'Pde1a', 'Grin2b', 'Atp1a3', 'Ntm', 'Sv2b',\n", " 'Lingo1', 'Ptprs', 'Ptprd', 'Cntn1', 'Sirpa', 'Scn2a', 'Adora1',\n", " 'Scn1b', 'Chl1', 'Rtn4', 'Ntng1', 'Nrcam', 'Rxfp1', 'Hrh3', 'Nptn',\n", " 'Gnas', 'Sorl1', 'Sv2a', 'Gpr161', 'Scn8a', 'Stx1a', 'Atp6ap2',\n", " 'Grm5', 'Sort1', 'Grin2a', 'Cnr1', 'Thy1', 'Nlgn1', 'Cadm1',\n", " 'Npr3', 'Scn2b', 'Opcml', 'App', 'Aplp1'], dtype=object),\n", " 'Etv5': array(['Epha5', 'Camk2a', 'Tspan5', 'Pde1a', 'Grin2b', 'Atp1a3', 'Ntm',\n", " 'Sv2b', 'Lingo1', 'Nrxn1', 'Ptprs', 'Ptprd', 'Gp1bb', 'Sirpa',\n", " 'Scn2a', 'Cntn1', 'Kcnj4', 'Scn1b', 'Rtn4', 'Nrcam', 'Nptn',\n", " 'Sorl1', 'Htr1f', 'Scn8a', 'Chrm3', 'Stx1a', 'Atp6ap2', 'Nrxn3',\n", " 'Grm5', 'Grin2a', 'Thy1', 'Cd47', 'Nlgn1', 'Nrxn2', 'Opcml', 'App',\n", " 'Cadm2', 'Tmem59l'], dtype=object),\n", " 'Foxa1': array(['Gucy2c'], dtype=object),\n", " 'Foxa2': array(['Ret', 'Ntsr1', 'Gucy2c'], dtype=object),\n", " 'Foxc2': array(['Mrc2', 'Gpr182', 'Thbd', 'Stab1', 'Notch2', 'Adam12', 'Cd248',\n", " 'Lsr', 'Cdh1', 'Anxa2', 'Asgr1', 'Mpzl2', 'Gjb2'], dtype=object),\n", " 'Foxd2': array(['Mrc2', 'Cdh1', 'Thbd', 'Anxa2'], dtype=object),\n", " 'Gata3': array([], dtype=float64),\n", " 'Glis3': array(['Fgfr2', 'Lrrtm4', 'F3', 'Ntsr2', 'Mertk', 'Ntm', 'Il1rapl1',\n", " 'Fgfr3', 'Trpc6'], dtype=object),\n", " 'Hivep2': array(['Camk2a', 'Fgfr2', 'Ntm', 'Il31ra', 'Atp1a3', 'Epha10', 'Oprm1',\n", " 'Lingo1', 'Sdk2', 'Adcy1', 'Gp1bb', 'Sirpa', 'Scn2a', 'Scn1a',\n", " 'Scn1b', 'Ntrk3', 'Ptprg', 'Il1rapl1', 'Cd44', 'Rxfp1', 'Tyro3',\n", " 'Sorl1', 'Cacna1b', 'Lrp11', 'Stx1a', 'Atp6ap2', 'Igsf9b', 'Rtn4r',\n", " 'Lrrtm4', 'Nptxr', 'Nrxn2', 'Opcml', 'Dscam', 'Tmem59l'],\n", " dtype=object),\n", " 'Jun': array(['Camk2a', 'Igsf5', 'Grin2a', 'Nptxr', 'Orai2', 'Cacna1e', 'Gpc4',\n", " 'Adcy1'], dtype=object),\n", " 'Junb': array(['Camk2a', 'Gp1bb', 'Sirpa', 'Epha4', 'Tspan13', 'Grm5', 'Grin2a',\n", " 'Pde1a', 'Grin2b', 'Atp6ap2', 'Nptxr', 'Nrxn2', 'Cacna1e', 'Sv2b',\n", " 'Stx1a', 'Nptn', 'Ptprs', 'Adcy1'], dtype=object),\n", " 'Kdm5a': array(['Cntn5', 'Lrrtm4'], dtype=object),\n", " 'Klf12': array(['Scn1a', 'Opcml', 'Il31ra', 'Il1rapl1'], dtype=object),\n", " 'Klf9': array(['Fgfr2', 'Ntm', 'Il31ra', 'Ptprd'], dtype=object),\n", " 'Lef1': array(['Ntng1', 'Vipr2', 'Cldn5', 'Il31ra'], dtype=object),\n", " 'Lmx1b': array(['Chrnb3', 'Ntsr1'], dtype=object),\n", " 'Maf': array(['Mrc2', 'Thbd', 'Stab1', 'Tgfbr3', 'Anxa2', 'Mpzl2', 'Gjb2',\n", " 'Gjb6', 'Slc6a12'], dtype=object),\n", " 'Mbnl2': array(['Camk2a', 'Sorcs1', 'Fgfr2', 'Pde1a', 'Ntm', 'Sv2b', 'Ptprs',\n", " 'Adcy1', 'Scn2a', 'Scn1a', 'Cacna1c', 'Ntrk3', 'Ptprg', 'Il1rapl1',\n", " 'Adam23', 'Cd44', 'Cacna1b', 'Cacna1d', 'Lrrtm4', 'Nptxr', 'Opcml',\n", " 'Dscam', 'Aplp1'], dtype=object),\n", " 'Mef2d': array(['Camk2a', 'Tspan5', 'Tspan13', 'Pde1a', 'Grin2b', 'Ildr2', 'Sv2b',\n", " 'Lingo1', 'Nrxn1', 'Ptprs', 'Adcy1', 'Ptprd', 'Acvr1b', 'Sirpa',\n", " 'Scn2a', 'Epha4', 'Lrfn5', 'Gp1bb', 'Cntn1', 'Scn1b', 'Chl1',\n", " 'Rtn4', 'Nrcam', 'Epha7', 'Nptn', 'Gnas', 'Tyro3', 'Igsf5',\n", " 'Sorl1', 'Pcdhga1', 'Negr1', 'Scn8a', 'Stx1a', 'Nlgn2', 'Atp6ap2',\n", " 'Nrxn3', 'Grm5', 'Rtn4r', 'Grin2a', 'Sort1', 'Grm7', 'Thy1',\n", " 'Lrrtm4', 'Nlgn1', 'Nptxr', 'Ramp1', 'Nrxn2', 'Opcml', 'Cacna1e',\n", " 'App', 'Cadm2', 'Tmem59l'], dtype=object),\n", " 'Msx1': array(['Thbd', 'Ntsr2', 'P2ry6', 'Tgfbr3', 'Cdh1', 'Mrc1', 'Anxa2',\n", " 'Asgr1', 'Fcgrt', 'Gjb2', 'Gjb6'], dtype=object),\n", " 'Mtf1': array([], dtype=float64),\n", " 'Nfatc4': array(['Thbd', 'Lsr'], dtype=object),\n", " 'Nfe2l2': array(['Mpzl2'], dtype=object),\n", " 'Nfib': array(['Gp1bb', 'Igsf5', 'Lrrtm4', 'Adcy9', 'Ntm', 'Nptxr', 'Il1rapl1',\n", " 'Lrp11', 'Orai2', 'Sv2b', 'Opcml'], dtype=object),\n", " 'Nfyb': array(['Camk2a', 'Gp1bb', 'Grm5', 'Epha4', 'Tspan13', 'Thy1', 'Pde1a',\n", " 'Grin2b', 'Nptn', 'Rtn4', 'Nptxr', 'Cacna1e', 'Sv2b', 'Stx1a',\n", " 'App', 'Lingo1', 'Ptprs'], dtype=object),\n", " 'Nkx6-1': array(['Sell', 'Cd248', 'Cd79b', 'Gjb2'], dtype=object),\n", " 'Nkx6-2': array(['Il1rap', 'Rpsa', 'Aplp1', 'Adipor2'], dtype=object),\n", " 'Nr2f1': array(['Gp1bb', 'Sirpa', 'Rtn4r', 'Lrpap1', 'Scn1b', 'Pcdhga1', 'Sv2b',\n", " 'Tmem59l', 'Adcy1'], dtype=object),\n", " 'Nr2f2': array(['Gpr39'], dtype=object),\n", " 'Nr3c1': array([], dtype=float64),\n", " 'Ovol2': array(['Camk2a'], dtype=object),\n", " 'Pbx1': array(['Dscam', 'Lrrtm4', 'Pde1a', 'Mertk', 'Ntm', 'Il31ra', 'Ptprg',\n", " 'Il1rapl1', 'Ret', 'Opcml', 'Sv2b', 'Igsf8', 'Cd44'], dtype=object),\n", " 'Pbx3': array(['Sv2c', 'Chrnb3', 'Ret', 'Chrna4'], dtype=object),\n", " 'Pknox2': array(['Camk2a', 'Gp1bb', 'Scn2a', 'Tspan5', 'Dscam', 'Cacna1b', 'Lrrtm4',\n", " 'Ntm', 'Nptxr', 'Il1rapl1', 'Opcml', 'Sv2b', 'Dcc', 'Stx1a',\n", " 'Lingo1', 'Igsf9b'], dtype=object),\n", " 'Pou3f2': array([], dtype=float64),\n", " 'Prox1': array(['Plxna4', 'Gpc4', 'Cldn11', 'Adcy1', 'Cacna1c', 'Mag', 'Lin7c',\n", " 'Il1r1', 'Epha7', 'Pde1b', 'Ncam2', 'Igsf5', 'Il1rap', 'Orai2',\n", " 'Thsd7a', 'Trpc6', 'Itga8', 'Crlf1', 'Npy2r'], dtype=object),\n", " 'Prrx2': array(['Anxa2', 'Tnfrsf11b', 'Gjb2'], dtype=object),\n", " 'Satb2': array(['Camk2a', 'Tspan5', 'Pde1a', 'Il31ra', 'Sv2b', 'Lingo1', 'Cckbr',\n", " 'Acvr1b', 'Gp1bb', 'Sirpa', 'Scn2a', 'Scn1a', 'Kcnj4', 'Scn1b',\n", " 'Il1rapl1', 'Tyro3', 'Cacna1b', 'Crhr1', 'Stx1a', 'Rtn4r', 'Sort1',\n", " 'Lrrtm4', 'Nptxr', 'Dscam', 'Plxnd1'], dtype=object),\n", " 'Sox10': array(['Lamp1', 'Itgad', 'Jam3', 'Mag', 'Mog', 'Cldn11', 'Aplp1',\n", " 'Adipor2'], dtype=object),\n", " 'Sox9': array(['Cd81', 'Ntrk2', 'Ezr', 'S1pr1', 'Plxnb1', 'F3', 'Mertk', 'Ntsr2',\n", " 'Ntm', 'Gpr37l1', 'Ptprz1', 'Cadm1', 'Sdc4', 'Fxyd1', 'Gjb6',\n", " 'Cd63'], dtype=object),\n", " 'Srebf1': array(['Cd81', 'Lamp1', 'S1pr1', 'Adgrg1', 'F3', 'Mertk', 'Mag',\n", " 'Gpr37l1', 'Ntsr2', 'Cd38', 'Mog', 'Sdc4', 'Ptprz1', 'Gjb6',\n", " 'Fgfr3', 'Cldn11'], dtype=object),\n", " 'Tbx18': array(['Thbd', 'Stab1', 'Tnfrsf11b', 'Cd74', 'Cd248', 'Tgfbr3', 'Cdh1',\n", " 'Anxa2', 'Acvrl1', 'Gjb2', 'Gjb6', 'Slc6a12', 'Vcam1'],\n", " dtype=object),\n", " 'Tcf4': array(['Camk2a', 'Plxna4', 'Epha5', 'Tspan5', 'Ptprj', 'Il31ra', 'Plxna2',\n", " 'Dcc', 'Lingo1', 'Ptprd', 'Sirpa', 'Ntrk2', 'Scn2a', 'Epha4',\n", " 'Lrfn5', 'Robo2', 'Alcam', 'Cdh10', 'Cacna1c', 'Scn1b', 'Cntnap2',\n", " 'Unc5d', 'Rtn4', 'Nrcam', 'Cntn5', 'Epha7', 'Ncam2', 'Kcnd2',\n", " 'Cacna1b', 'Trhde', 'Ptprz1', 'Pcdhga1', 'Ptprt', 'Negr1', 'Stx1a',\n", " 'Grm5', 'Sort1', 'Grin2a', 'Thy1', 'Grm7', 'Cd47', 'Cadm1',\n", " 'Nrxn2', 'Lrrc4c', 'Cacna1e', 'App', 'Epha6', 'Kcnh1', 'Fgfr2',\n", " 'Tspan13', 'Pde1a', 'Grin2b', 'Ntm', 'Adcy2', 'Sv2b', 'Ptprs',\n", " 'Adcy1', 'Cntn1', 'Gp1bb', 'Kcnj4', 'Chl1', 'Cdh11', 'Ntrk3',\n", " 'Ptprg', 'Il1rapl1', 'Nptn', 'Sorl1', 'Ezr', 'Cacna1d', 'Ncam1',\n", " 'Scn8a', 'Chrm3', 'Nrxn3', 'Cnr1', 'Lrrtm4', 'Erbb4', 'Nlgn1',\n", " 'Htr4', 'Mertk', 'Nptxr', 'Opcml', 'Dscam', 'Scn3a'], dtype=object),\n", " 'Tcf7l2': array(['Fgfr2', 'Ptprz1', 'Mag', 'Gpr37l1', 'Il31ra', 'Ptprm', 'Mog',\n", " 'Cd44', 'Cd9', 'Cldn11', 'Gpr37'], dtype=object),\n", " 'Thra': array(['Gp1bb', 'Pcdhga1', 'Ramp1'], dtype=object),\n", " 'Thrb': array(['Gp1bb', 'Opcml'], dtype=object),\n", " 'Vsx1': array(['Mrc2', 'Thbd', 'Adam12', 'Cd55', 'Cdh1', 'Anxa2', 'Mpzl2', 'Gjb2',\n", " 'Tgfbr3'], dtype=object)}" ] }, "execution_count": 32, "metadata": {}, "output_type": "execute_result" } ], "source": [ "adata.uns['receptor_dict']" ] }, { "cell_type": "markdown", "id": "fcaf2ab0", "metadata": {}, "source": [ "ISR matrix (n cells x m regulons) was stored in adata.obsm under key `isr` in pd.Dataframe format." ] }, { "cell_type": "code", "execution_count": null, "id": "3196f952-e366-4129-afa6-e33b682b7ed2", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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" Atf2(+) Atf4(+) Bcl11a(+) Bcl6(+) Bnc2(+) Cebpb(+) \\\n",
"Cell \n",
"Cell_1 0.156431 0.111644 0.098457 0.000000 0.033453 0.085540 \n",
"Cell_1000 0.212292 0.218080 0.164389 0.053236 0.056976 0.215377 \n",
"Cell_10000 0.111001 0.060451 0.075737 0.000000 0.032233 0.107542 \n",
"Cell_10001 0.081370 0.148219 0.101323 0.086841 0.028692 0.177124 \n",
"Cell_10002 0.139363 0.371802 0.186718 0.074740 0.000000 0.286048 \n",
"... ... ... ... ... ... ... \n",
"Cell_9994 0.081529 0.192922 0.121566 0.000000 0.011434 0.107356 \n",
"Cell_9996 0.253249 0.273179 0.174062 0.058310 0.078524 0.259639 \n",
"Cell_9997 0.190197 0.204892 0.185552 0.089932 0.016441 0.182882 \n",
"Cell_9998 0.240043 0.216039 0.157211 0.226659 0.027269 0.211629 \n",
"Cell_9999 0.143029 0.303464 0.129246 0.171726 0.023894 0.087445 \n",
"\n",
" Cebpd(+) Dbp(+) Dlx1(+) Ebf1(+) ... Satb2(+) Sox10(+) \\\n",
"Cell ... \n",
"Cell_1 0.000000 0.170651 0.122474 0.000000 ... 0.099124 0.030581 \n",
"Cell_1000 0.060005 0.180853 0.053370 0.000000 ... 0.124200 0.023578 \n",
"Cell_10000 0.000000 0.134629 0.040831 0.000000 ... 0.079151 0.021887 \n",
"Cell_10001 0.000000 0.187842 0.034786 0.000000 ... 0.062423 0.040046 \n",
"Cell_10002 0.000000 0.324644 0.075673 0.075543 ... 0.104446 0.040820 \n",
"... ... ... ... ... ... ... ... \n",
"Cell_9994 0.000000 0.079788 0.091360 0.000000 ... 0.072796 0.048270 \n",
"Cell_9996 0.000000 0.178899 0.204684 0.163190 ... 0.140081 0.041906 \n",
"Cell_9997 0.052197 0.216455 0.096070 0.000000 ... 0.139947 0.031018 \n",
"Cell_9998 0.000000 0.173408 0.153566 0.083944 ... 0.146612 0.053716 \n",
"Cell_9999 0.000000 0.420941 0.067038 0.000000 ... 0.073910 0.077494 \n",
"\n",
" Sox9(+) Srebf1(+) Tbx18(+) Tcf4(+) Tcf7l2(+) Thra(+) \\\n",
"Cell \n",
"Cell_1 0.043982 0.108448 0.000000 0.282513 0.121834 0.123972 \n",
"Cell_1000 0.023990 0.059154 0.000000 0.368584 0.047002 0.218843 \n",
"Cell_10000 0.069703 0.349720 0.000000 0.320939 0.076905 0.085574 \n",
"Cell_10001 0.135491 0.336981 0.000000 0.172192 0.035783 0.144633 \n",
"Cell_10002 0.137917 0.359795 0.000000 0.311838 0.066502 0.279441 \n",
"... ... ... ... ... ... ... \n",
"Cell_9994 0.059478 0.116394 0.000000 0.124870 0.011098 0.116962 \n",
"Cell_9996 0.123377 0.315487 0.000000 0.347189 0.114236 0.220211 \n",
"Cell_9997 0.139405 0.583368 0.000000 0.314701 0.095673 0.242292 \n",
"Cell_9998 0.107629 0.365332 0.000000 0.579174 0.114361 0.212512 \n",
"Cell_9999 0.173375 0.530861 0.018987 0.336947 0.084933 0.217689 \n",
"\n",
" Thrb(+) Vsx1(+) \n",
"Cell \n",
"Cell_1 0.103947 0.0 \n",
"Cell_1000 0.112490 0.0 \n",
"Cell_10000 0.074182 0.0 \n",
"Cell_10001 0.052906 0.0 \n",
"Cell_10002 0.090039 0.0 \n",
"... ... ... \n",
"Cell_9994 0.060993 0.0 \n",
"Cell_9996 0.146768 0.0 \n",
"Cell_9997 0.116345 0.0 \n",
"Cell_9998 0.162407 0.0 \n",
"Cell_9999 0.068903 0.0 \n",
"\n",
"[50140 rows x 63 columns]"
]
},
"execution_count": 22,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"adata.obsm['isr']"
]
},
{
"cell_type": "markdown",
"id": "e52be4bd",
"metadata": {},
"source": [
"## Part III. Visualization of the network"
]
},
{
"cell_type": "code",
"execution_count": 25,
"id": "13c85f0e-9ea0-44a0-a605-7fa0ca83831f",
"metadata": {},
"outputs": [],
"source": [
"import spagrn.plot as prn"
]
},
{
"cell_type": "markdown",
"id": "c3587377",
"metadata": {},
"source": [
"### Regulon 2D spatially distribution plot\n",
"`plot_2d` plots the spatial distribution of the regulon activity level, with each point representing a spatial location and the color indicating the ISR value of the corresponding regulon."
]
},
{
"cell_type": "code",
"execution_count": 29,
"id": "d265482b",
"metadata": {},
"outputs": [],
"source": [
"%matplotlib inline\n",
"prn.plot_2d(adata, adata.obsm['auc_mtx'], pos_label='spatial', reg_name='Pbx3', fn='Pbx3.png')"
]
},
{
"cell_type": "markdown",
"id": "133b72fc-9ac3-4d03-810c-d9737c9bc43a",
"metadata": {},
"source": [
"| \n", " | Atf2(+) | \n", "Atf4(+) | \n", "Bcl11a(+) | \n", "Bcl6(+) | \n", "Bnc2(+) | \n", "Cebpb(+) | \n", "Cebpd(+) | \n", "Dbp(+) | \n", "Dlx1(+) | \n", "Ebf1(+) | \n", "... | \n", "Satb2(+) | \n", "Sox10(+) | \n", "Sox9(+) | \n", "Srebf1(+) | \n", "Tbx18(+) | \n", "Tcf4(+) | \n", "Tcf7l2(+) | \n", "Thra(+) | \n", "Thrb(+) | \n", "Vsx1(+) | \n", "
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cell | \n", "\n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " | \n", " |
| Cell_1 | \n", "0.156431 | \n", "0.111644 | \n", "0.098457 | \n", "0.000000 | \n", "0.033453 | \n", "0.085540 | \n", "0.000000 | \n", "0.170651 | \n", "0.122474 | \n", "0.000000 | \n", "... | \n", "0.099124 | \n", "0.030581 | \n", "0.043982 | \n", "0.108448 | \n", "0.000000 | \n", "0.282513 | \n", "0.121834 | \n", "0.123972 | \n", "0.103947 | \n", "0.0 | \n", "
| Cell_1000 | \n", "0.212292 | \n", "0.218080 | \n", "0.164389 | \n", "0.053236 | \n", "0.056976 | \n", "0.215377 | \n", "0.060005 | \n", "0.180853 | \n", "0.053370 | \n", "0.000000 | \n", "... | \n", "0.124200 | \n", "0.023578 | \n", "0.023990 | \n", "0.059154 | \n", "0.000000 | \n", "0.368584 | \n", "0.047002 | \n", "0.218843 | \n", "0.112490 | \n", "0.0 | \n", "
| Cell_10000 | \n", "0.111001 | \n", "0.060451 | \n", "0.075737 | \n", "0.000000 | \n", "0.032233 | \n", "0.107542 | \n", "0.000000 | \n", "0.134629 | \n", "0.040831 | \n", "0.000000 | \n", "... | \n", "0.079151 | \n", "0.021887 | \n", "0.069703 | \n", "0.349720 | \n", "0.000000 | \n", "0.320939 | \n", "0.076905 | \n", "0.085574 | \n", "0.074182 | \n", "0.0 | \n", "
| Cell_10001 | \n", "0.081370 | \n", "0.148219 | \n", "0.101323 | \n", "0.086841 | \n", "0.028692 | \n", "0.177124 | \n", "0.000000 | \n", "0.187842 | \n", "0.034786 | \n", "0.000000 | \n", "... | \n", "0.062423 | \n", "0.040046 | \n", "0.135491 | \n", "0.336981 | \n", "0.000000 | \n", "0.172192 | \n", "0.035783 | \n", "0.144633 | \n", "0.052906 | \n", "0.0 | \n", "
| Cell_10002 | \n", "0.139363 | \n", "0.371802 | \n", "0.186718 | \n", "0.074740 | \n", "0.000000 | \n", "0.286048 | \n", "0.000000 | \n", "0.324644 | \n", "0.075673 | \n", "0.075543 | \n", "... | \n", "0.104446 | \n", "0.040820 | \n", "0.137917 | \n", "0.359795 | \n", "0.000000 | \n", "0.311838 | \n", "0.066502 | \n", "0.279441 | \n", "0.090039 | \n", "0.0 | \n", "
| ... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "... | \n", "
| Cell_9994 | \n", "0.081529 | \n", "0.192922 | \n", "0.121566 | \n", "0.000000 | \n", "0.011434 | \n", "0.107356 | \n", "0.000000 | \n", "0.079788 | \n", "0.091360 | \n", "0.000000 | \n", "... | \n", "0.072796 | \n", "0.048270 | \n", "0.059478 | \n", "0.116394 | \n", "0.000000 | \n", "0.124870 | \n", "0.011098 | \n", "0.116962 | \n", "0.060993 | \n", "0.0 | \n", "
| Cell_9996 | \n", "0.253249 | \n", "0.273179 | \n", "0.174062 | \n", "0.058310 | \n", "0.078524 | \n", "0.259639 | \n", "0.000000 | \n", "0.178899 | \n", "0.204684 | \n", "0.163190 | \n", "... | \n", "0.140081 | \n", "0.041906 | \n", "0.123377 | \n", "0.315487 | \n", "0.000000 | \n", "0.347189 | \n", "0.114236 | \n", "0.220211 | \n", "0.146768 | \n", "0.0 | \n", "
| Cell_9997 | \n", "0.190197 | \n", "0.204892 | \n", "0.185552 | \n", "0.089932 | \n", "0.016441 | \n", "0.182882 | \n", "0.052197 | \n", "0.216455 | \n", "0.096070 | \n", "0.000000 | \n", "... | \n", "0.139947 | \n", "0.031018 | \n", "0.139405 | \n", "0.583368 | \n", "0.000000 | \n", "0.314701 | \n", "0.095673 | \n", "0.242292 | \n", "0.116345 | \n", "0.0 | \n", "
| Cell_9998 | \n", "0.240043 | \n", "0.216039 | \n", "0.157211 | \n", "0.226659 | \n", "0.027269 | \n", "0.211629 | \n", "0.000000 | \n", "0.173408 | \n", "0.153566 | \n", "0.083944 | \n", "... | \n", "0.146612 | \n", "0.053716 | \n", "0.107629 | \n", "0.365332 | \n", "0.000000 | \n", "0.579174 | \n", "0.114361 | \n", "0.212512 | \n", "0.162407 | \n", "0.0 | \n", "
| Cell_9999 | \n", "0.143029 | \n", "0.303464 | \n", "0.129246 | \n", "0.171726 | \n", "0.023894 | \n", "0.087445 | \n", "0.000000 | \n", "0.420941 | \n", "0.067038 | \n", "0.000000 | \n", "... | \n", "0.073910 | \n", "0.077494 | \n", "0.173375 | \n", "0.530861 | \n", "0.018987 | \n", "0.336947 | \n", "0.084933 | \n", "0.217689 | \n", "0.068903 | \n", "0.0 | \n", "
50140 rows × 63 columns
\n", "![](\"Pbx3.png\")
"
]
},
{
"cell_type": "markdown",
"id": "29a499b8",
"metadata": {},
"source": [
"### Heatmaps\n",
"`auc_heatmap` visualize the activity levels of regulons across cells, allowing for easy comparison and identification of trends or patterns. By clustering the cells based on regulon activities, one can see whether there are groups of cells that tend to have the same regulons active, and reveal the network states that are recurrent across multiple cells.\n",
"#### 1. regular heatmap"
]
},
{
"cell_type": "code",
"execution_count": null,
"id": "b1c504d4",
"metadata": {},
"outputs": [],
"source": [
"prn.auc_heatmap(data,\n",
" auc_mtx,\n",
" cluster_label='annotation',\n",
" topn=10,\n",
" subset=False,\n",
" save=True,\n",
" fn=f'{out_dir}/{method}_clusters_heatmap_top10.png',\n",
" legend_fn=f\"{out_dir}/{method}_rss_celltype_legend_top10.png\")"
]
}
],
"metadata": {
"kernelspec": {
"display_name": "Python 3 (ipykernel)",
"language": "python",
"name": "python3"
},
"language_info": {
"codemirror_mode": {
"name": "ipython",
"version": 3
},
"file_extension": ".py",
"mimetype": "text/x-python",
"name": "python",
"nbconvert_exporter": "python",
"pygments_lexer": "ipython3",
"version": "3.8.12"
}
},
"nbformat": 4,
"nbformat_minor": 5
}